Results 91 to 100 of about 3,603 (218)

THE RADICAL C-H FUNCTIONALIZATION OF NATURAL COMPOUNDS

Studia Universitatis Moldaviae: Stiinte reale si ale naturii, 2019
Selective functionalization of complex scaffolds is a promising approach to increase the pharmacological profiles of natural products and their derivatives.
Vladilena GÎRBU
doaj  

1,6-Nucleophilic Di- and Trifluoromethylation of para-Quinone Methides with Me₃SiCF₂H/Me₃SiCF₃ Facilitated by CsF/18-Crown-6

Molecules
The direct 1,6-nucleophilic difluoromethylation, trifluoromethylation, and difluoroalkylation of para-quinone methides (p-QMs) with Me3SiRf (Rf = CF2H, CF3, CF2CF3, CF2COOEt, and CF2SPh) under mild conditions are described. Although Me3SiCF2H shows lower
Dingben Chen, Ling Huang, Mingyu Liang, Xiaojing Chen, Dongdong Cao, Pan Xiao, Chuanfa Ni, Jinbo Hu   +7 more
doaj   +1 more source

Copper-mediated C-H trifluoromethylation of quinones

, 2013
Quinones undergo copper-mediated C-H trifluoromethylation reactions using a hypervalent iodine reagent. The reactions have a broad synthetic scope involving naphtho, alkyl, chloro and methoxy quinones.
Janson, Pär,, Szabó, Kálmán J.,, Ilchenko, Nadia O.,   +2 more
core   +1 more source

Carbon–carbon bond cleavage for Cu-mediated aromatic trifluoromethylations and pentafluoroethylations

Beilstein Journal of Organic Chemistry, 2015
This short review highlights the copper-mediated fluoroalkylation using perfluoroalkylated carboxylic acid derivatives. Carbon–carbon bond cleavage of perfluoroalkylated carboxylic acid derivatives takes place in fluoroalkylation reactions at high ...
Tsuyuka Sugiishi, Hideki Amii, Kohsuke Aikawa, Koichi Mikami   +3 more
doaj   +1 more source

Trifluoromethylation of Fullerenes: Kinetic and Thermodynamic Control

, 2016
We present a survey and theoretical interpretation of the experimental results on trifluoromethylation of fullerenes. A thermodynamic model has been developed to describe the C60/70(CF3)n condensed phase mixtures capable of free exchange of addends and ...
Ilya N. Ioffe (1746379), Alexey A. Goryunkov (1875289), Daria V. Ignat’eva (1875292), Lev N. Sidorov (1870384)   +3 more
core   +1 more source

CF3SO2X (X = Na, Cl) as reagents for trifluoromethylation, trifluoromethylsulfenyl-, -sulfinyl- and -sulfonylation and chlorination. Part 2: Use of CF3SO2Cl

Beilstein Journal of Organic Chemistry, 2017
The recent progresses of the application of trifluoromethanesulfonyl chloride, CF3SO2Cl, in the formation of C–CF3, C–SCF3, C–SOCF3, and C–Cl bonds are summarised in this second part of a two-part review published back-to-back on both sodium ...
Hélène Chachignon, Hélène Guyon, Dominique Cahard   +2 more
doaj   +1 more source

Copper-Catalyzed Trifluoromethylation of Terminal Alkenes through Allylic C–H Bond Activation

, 2016
An unprecedented type of reaction for Cu-catalyzed trifluoromethylation of terminal alkenes is reported. This reaction represents a rare instance of catalytic trifluoromethylation through C(sp3)–H activation.
Bin Xiao (146435), Jun Xu (45543), Dong-Fen Luo (2164171), Yao Fu (386864), Zhao-Jing Liu (1856809), Tian-Jun Gong (1856812), Yuan-Ye Jiang (1642738), Lei Liu (5074)   +7 more
core   +1 more source

1,2-Oxidative Trifluoromethylation of Olefin with Ag(O₂CCF₂SO₂F) and O₂: Synthesis of α-Trifluoromethyl Ketones

Molecules
A novel and efficient 1,2-oxidative trifluoromethylation of olefins employing Ag(O2CCF2SO2F) as a trifluoromethyl source is described with O2 as the oxidant, which provides access to a variety of valuable α-trifluoromethyl-substituted ketones.
Shengxue Zhang, Wangchuan Xiao, Jingjing Wu, Fanhong Wu, Houjin Huang, Xiaoyu Ma, Yafei Shi, Chao Liu   +7 more
doaj   +1 more source

Pd-Catalyzed Direct C7 Trifluoromethylation of Indolines with Umemoto’s Reagent

An efficient palladium-catalyzed region-selective C7-trifluoromethylation of indolines using commercially available Umemoto’s reagent was reported. The reaction utilizing Umemoto’s reagent as CF3 radical precursor, pyrimidine as a removable directing ...
Shaofeng Wu (4029884), Yonghong Zhang (20918), Ziren Chen (8177262), Chenjiang Liu (1652149), Qinglang Song (16610150), Yu Xia (8822), Lin Zhang (8926), Bin Wang (30851), Weiwei Jin (263276)   +8 more
core   +1 more source

Silver-Catalyzed C–H Trifluoromethylation of Arenes Using Trifluoroacetic Acid as the Trifluoromethylating Reagent

, 2016
Direct trifluoromethylation of arenes using TFA as the trifluoromethylating reagent was achieved with Ag as the catalyst. This reaction not only provides a new protocol for aryl C–H trifluoromethylation, but the generation of CF3· from TFA may prove ...
Shulei Pan (1590091), Yanghui Zhang (1590094), Changdong Shao (1590085), Guangfa Shi (1590088), Jingxun Yu (1695988)   +4 more
core   +1 more source