Results 121 to 130 of about 9,021 (263)

A Review of Vagus Nerve Stimulation for Disease: Comprehensive Theory and Evidence for Mechanisms of Action

Comprehensive Physiology, Volume 16, Issue 2, April 2026.
Vagus nerve stimulation (VNS) effects span central and peripheral organ systems through diverse mechanistic pathways. This comprehensive review provides a unified synthesis of these mechanisms across neurological, cardiovascular, immunological, metabolic, and gastrointestinal domains, filling a critical gap and serving as a foundational resource for ...
Yifeng Bu, Alex Liang, Benjamin U. Hoffman, Dawn M. Schiehser, Oliver Case, Alan Simmons, Ruth Klaming, Andres Gottfried‐Blackmore, Ravinder K. Mittal, Christopher Puleo, Hubert Lim, Imanuel Lerman   +11 more
wiley   +1 more source

Inhaled 5‐HT1B/1D Receptor Antagonist Attenuates Sumatriptan‐Induced Sensitization of Capsaicin‐Sensitive Lung Vagal Afferents: Implications for Preventing Sumatriptan‐Associated Adverse Chest Symptoms

Comprehensive Physiology, Volume 16, Issue 2, April 2026.
Our previous study suggests that sumatriptan‐induced chest discomfort is associated with hypersensitivity of CSLV afferents via 5‐HT1B/1D receptors on nerve endings. The present study demonstrates that inhaled 5‐HT1B/1D receptor antagonism suppresses this hypersensitivity without compromising antimigraine efficacy, supporting local pulmonary antagonism
Nai‐Ju Chan, Zung Fan Yuan, Chang‐Chih Kuo, Chun‐Chun Hsu   +3 more
wiley   +1 more source

Neural mechanism of trigeminal nerve stimulation recovering defensive arousal responses in traumatic brain injury [PDF]

Qian Zhang, Haiyun Ma, Lifang Huo, Shao Ling Wang, Qian Yang, Zhimin Ye, Jie Cao, Shaoling Wu, Chao Ma, Congping Shang   +9 more
openalex   +1 more source

Periodontitis and extracellular vesicles: Emerging roles in inflammation, tissue destruction and systemic crosstalk

Clinical and Translational Discovery, Volume 6, Issue 2, April 2026.
Extracellular vesicles released from periodontal tissues and pathogens mediate local inflammation and disseminate systemically via the circulation. By transporting regulatory microRNAs and inflammatory cytokines, these vesicles link periodontitis to systemic inflammatory conditions and represent emerging targets for minimally invasive diagnostics and ...
Mai Ahmed, Dada Oluwaseyi Temilola, Mushi Matjila, Manogari Chetty   +3 more
wiley   +1 more source

Evolving Paradigms in the Management of Trigeminal Nerve Injuries Post Oral Surgery: A Comprehensive Narrative Review. [PDF]

Cureus
Tank S, Patil A, Patil T, Kshirsagar MM, Bedia AS, Sachdev SS, Mundada V.   +6 more
europepmc   +1 more source

Effect of Functional Nasal Surgery on Craniofacial Pain: A Prospective Cohort Study

The Laryngoscope, Volume 136, Issue 4, Page 1649-1655, April 2026.
About 40% of patients presenting for nasal obstruction had craniofacial pain (CPF) preoperatively. In patients with nasal obstruction and CFP preoperatively, functional nasal surgery led to significant improvements in both nasal obstruction and CFP, and these improvements persisted at about 6 months postoperatively. ABSTRACT Objectives Functional nasal
John R. Craig, Jeewanjot S. Grewal, Anne Grossbauer, Carl Wilson, Robert H. Deeb   +4 more
wiley   +1 more source

Anterior Ethmoid Artery Ligation for Epistaxis: A Systematic Review

Laryngoscope Investigative Otolaryngology, Volume 11, Issue 2, April 2026.
ABSTRACT Objective For intractable epistaxis unresponsive to conservative measures, surgical intervention, such as anterior ethmoid artery ligation (AEAL), can control bleeding in the superior nasal cavity. Yet, the literature is limited around AEAL for epistaxis control.
Wynne Zheng, Christina Zhu, Jiling Chou, Jason Crossley, Timothy R. DeKlotz, Daniel B. Spielman   +5 more
wiley   +1 more source

Clinical Statistics of Iatrogenic Trigeminal Nerve Injury

Journal of Japanese Society of Oral Medicine, 2021
Hiroyoshi YAMAMOTO, Akihiro NISHIYAMA, Kei SUGIURA, Sei TANAKA, Azusa YAMAZAKI, Takaharu ARIIZUMI, Masato MURAYAMA, Kiyohiro KASAHARA, Masayuki TAKANO, Akira KATAKURA   +9 more
openaire   +2 more sources

Epigenetic mechanisms and therapeutic innovations in chronic pain‐associated neuropsychiatric co‐morbidities

British Journal of Pharmacology, Volume 183, Issue 7, Page 1313-1340, April 2026.
Abstract Chronic pain, marked by nociceptive sensitization and maladaptive neuroplasticity, affects 30% of the global population with escalating socioeconomic burdens. Epidemiological data show a 2‐3‐fold increase in neuropsychiatric co‐morbidities among individuals with chronic pain, where epigenetic dysregulation serves as a key mechanism linking ...
Kai Zhang, Sijia Zhu, Na Xing, Zhen Zhou, Jiayi Chen, Tianen Si, Mingrui Li, Lin Jia, Yousef Rastegar‐Kashkooli, Tom J. Wang, Wei Zhu, Jing Li, Chao Jiang, Junmin Wang, Moxin Wu, Xiaoping Yin, Weidong Zang, Jian Wang, Songxue Su   +18 more
wiley   +1 more source

Efficacy and Safety of Repeated Radiofrequency Thermocoagulation on Trigeminal Neuralgia Patients

Pain Practice, Volume 26, Issue 4, April 2026.
ABSTRACT Background Trigeminal neuralgia (TN) is a pain condition characterized by paroxysmal, electric shock‐like facial pain, affecting one or more areas of the branches. Approximately 33%–50% of patients require invasive treatment. Radiofrequency thermocoagulation (RFTC) is an established method for managing drug‐resistant and chronic TN. This study
Antti J. Luikku, Sara Matikka, Sami Heikkinen, Anssi Lipponen, Katja Luostarinen, Timo Koivisto, Ville Leinonen, Jukka Huttunen, Henna‐Kaisa Jyrkkänen   +8 more
wiley   +1 more source