Results 81 to 90 of about 162,489 (254)

Strategies for inducing diabetes in laboratory animals: Advances from chemical, surgical, immunologic, dietary, and genetic approaches

Animal Models and Experimental Medicine, EarlyView.
This review summarizes the principal experimental approaches used to induce diabetes in animal models. Strategies include chemical agents (streptozotocin, alloxan, dithizone, gold thioglucose), dietary interventions (high‐fat and high‐sugar diets), surgical methods (total or partial pancreatectomy), genetic models (db/db, ob/ob, Goto‐Kakizaki [GK ...
Milad Faraji, Maedeh Faraji, Nasrin Kazemipour   +2 more
wiley   +1 more source

The liver‐brain axis: A multidimensional regulatory network implicated in Alzheimer's disease pathogenesis and clinical implications

Animal Models and Experimental Medicine, EarlyView.
Schematic diagram of the core pathways of the liver‐brain axis in regulating AD. The liver regulates cerebral Aβ deposition, tau phosphorylation, and neuroinflammation through pathways such as metabolic detoxification (urea cycle, ketone body metabolism, glutathione antioxidant system), molecular secretion (APOE, CRP, FGF21, IGF‐1), and Aβ clearance ...
Ning Zhang, Wei Chen, Meng Wang
wiley   +1 more source

Diabetes and the Metabolic Syndrome as Drivers of Neurodegeneration: Convergent Mechanisms Linking Peripheral Neuropathy and Dementia

Annals of Neurology, EarlyView.
The metabolic syndrome, a state of progressive metabolic dysfunction, injures the peripheral and central nervous systems, promoting peripheral neuropathy (PN) and cognitive impairment (CI), respectively. We posit PN and CI are connected in the metabolic syndrome framework, built on the premise that neurons, whether in the peripheral or central nervous ...
Masha G. Savelieff, David L. Bennett, Troels S. Jensen, Eva L. Feldman   +3 more
wiley   +1 more source

Association of the triglyceride-glucose index and its related parameters with frailty

Lipids in Health and Disease
Background Frailty is a dynamic geriatric condition. Limited studies have examined the association of the triglyceride-glucose (TyG) index and its related indicators [TyG index, triglyceride glucose-waist to height ratio (TyG-WHtR), triglyceride glucose ...
Huangyi Yin, Liuqing Guo, Wei Zhu, Weishan Li, Yubo Zhou, Wenyun Wei, Min Liang   +6 more
doaj   +1 more source

Triglyceride-Glucose Index as a Predictor of Outcome in Elderly Patients with Acute Coronary Syndrome: A Cross-sectional Observational Study

APIK Journal of Internal Medicine
Background: This study aims to evaluate the triglyceride-glucose (Ty-G) index for predicting outcome in elderly patients with acute coronary syndrome (ACS).
Pankaj Kumar Jain, Vikas Meena, Rajesh Yadav, Kamal Kumar Rachhoya   +3 more
doaj   +1 more source

Hemoglobin glycation index and triglyceride-glucose index are related to diabetic nephropathy

Cirugía y Cirujanos (English Edition)
Diabetic nephropathy (DN) is a significant complication of diabetes. Despite strict management of fasting plasma glucose (FPG), DN may progress to end-stage renal disease. HbA1c, the best biomarker for glycemic management, may differ in similar FPG. Hemoglobin glycation index (HGI) = HbA1c as determined minus HbA1c as predicted.
openaire   +2 more sources

Hepatic morphology and serum biochemical profile according to dry and rainy seasons in Pygocentrus nattereri (Characiformes: Serrasalmidae)

The Anatomical Record, EarlyView.
Abstract This study investigated the physiological and morphological adaptations of the liver of the carnivorous fish Pygocentrus nattereri (piranha) in response to seasonal variations (dry and rainy seasons) in the Brazilian Pantanal. The objective was to describe how the liver, a central organ in metabolic regulation, responds to environmental ...
Maria Eduarda Corona Garcia, Sandriely F. Marcondes, Mayara S. Siqueira, Taynara R. F. Leão, Robson A. Rodrigues, Karine N. N. Farias, André L. N. Silva, Karin Virgínia Kuibida, Lilian Franco‐Belussi, Carlos E. Fernandes   +9 more
wiley   +1 more source

Triglyceride-glucose (TyG) index combined with C-reactive protein outperforms the TyG index alone in predicting stroke in arthritis patients: a nationwide prospective cohort study

Lipids in Health and Disease
Background Arthritis patients exhibit a higher stroke risk, but effective predictive biomarkers are scarce. This research sought to examine and compare the associations between the triglyceride-glucose (TyG) index, its integration with C-reactive protein
Zhongwei Zhou, Jianshu Gao, Mingzhong Sun, Hongmei Chen, Hao Jin, Huixiang Ju   +5 more
doaj   +1 more source

Triglyceride-glucose index and triglyceride-glucose–body mass index as prognostic factors for early stage breast cancer patients receiving neoadjuvant chemotherapy

Translational Oncology
Background: Insulin resistance (IR) is closely associated with the risk of breast cancer. The triglyceride-glucose (TyG) index and the triglyceride-glucose–body mass index (TyG-BMI) are considered surrogate indicators of IR; however, their prognostic ...
Fucheng Li, Tian Gao, Zhaoting Li, He Dou, Yuling Ba, Siyuan Jia, Danli Luo, Min Xiao   +7 more
doaj   +1 more source

Comparative Meta‐Analysis of Antimicrobial Peptides in Aquatic and Terrestrial Livestock Species

Animal Research and One Health, EarlyView.
A global meta‐analysis of 58 studies (926 effect sizes and 29 species across five taxa) revealed that dietary antimicrobial peptides generally improve growth performance, blood metabolites, and immune responses. The greatest benefits were observed in omnivorous livestock, such as pigs and chickens. Dose‐duration effects were evident. An optimal outcome
Lily Liu, Xu Luo, Qin Zhang, Jinhai Wang, Alan E. Wilson   +4 more
wiley   +1 more source