Results 101 to 110 of about 214,665 (297)

Genetic Risk and High Burden of Depression and Suicide in the Maya‐Mestizo Population of Yucatán, México

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT Major depression and suicide are critical public health concerns, particularly in underrepresented populations with unique genetic and sociocultural contexts. The Maya‐mestizo population presents the highest suicide rates in the country but remains understudied in psychiatric genetics. This study evaluated the association between three genetic
Marta Menjivar, Erandi Bravo, Margarita Rivera‐Balancan, Barbara Itzel Pena Espinoza   +3 more
wiley   +1 more source

The triglyceride glucose index and cardiovascular disease outcomes

The Lancet Healthy Longevity, 2023
David, Flood, Luisa Campos Caldeira, Brant, Jeremy B, Sussman   +2 more
openaire   +2 more sources

Black Beans, Fiber, and Antioxidant Capacity Pilot Study: Examination of Whole Foods vs. Functional Components on Postprandial Metabolic, Oxidative Stress, and Inflammation in Adults with Metabolic Syndrome. [PDF]

, 2015
Beans (Phaseolus vulgaris) contain bioactive components with functional properties that may modify cardiovascular risk. The aims of this pilot study were to evaluate the ability of black beans to attenuate postprandial metabolic, oxidative stress, and ...
Burton-Freeman, Britt M, Edirisinghe, Indika, Kappagoda, C Tissa, Randolph, Jody M, Reverri, Elizabeth J, Steinberg, Francene M   +5 more
core   +3 more sources

Tree shrew model of early diabetic retinopathy reveals microvascular dysfunction and identifies phosphoserine aminotransferase 1 as a novel therapeutic target

Animal Models and Experimental Medicine, EarlyView.
We developed an animal model of early diabetic retinopathy (DR) in the tree shrew by feeding a high‐fat and high‐sugar diet in combination with STZ. Physiological and biochemical index detection, hematoxylin and eosin staining, and transmission electron microscopy were performed to examine DR.
Min Qiu, Shurui Huo, Wenguang Wang, Na Li, Qingwei Zeng, Xiaomei Sun, Jiejie Dai, Pinfen Tong, Yuanyuan Han, Ling Zhao, Caixia Lu   +10 more
wiley   +1 more source

Cardiovascular disease risk factor responses to a type 2 diabetes care model including nutritional ketosis induced by sustained carbohydrate restriction at 1 year: An open label, non-randomized, controlled study [PDF]

, 2018
Additional file 1: Table S1. Detailed baseline characteristics for participants in the continuous care intervention (CCI) and usual care (UC ...
Ballard, Kevin D, Bhanpuri, Nasir H, Campbell, Wayne W, Hallberg, Sarah J, McCarter, James P, McKenzie, Amy L, Phinney, Stephen D, Volek, Jeff S, Williams, Paul T   +8 more
core   +4 more sources

Metabolic and biochemical profiling reveals phenotypic heterogeneity in Zucker diabetic fatty rats

Animal Models and Experimental Medicine, EarlyView.
Genetically uniform Zucker Diabetic Fatty (ZDF) rats spontaneously develop four distinct metabolic phenotypes despite identical housing and diet conditions. Each phenotype exhibits unique biomarker signatures encompassing glucose homeostasis, insulin secretion, polyol pathway activation, oxidative stress, inflammatory cytokines, and neurotrophic ...
Marek Lepáček, Pavol Boďo, Barbora Kaločayová, Marta Šoltésová Prnová   +3 more
wiley   +1 more source

Association of triglyceride-glucose index and its combinations with sarcopenia among community-dwelling older adults: based on the Chongqing Aging and Sarcopenia Evaluation (CHASE) cohort

Frontiers in Physiology
BackgroundThe triglyceride-glucose (TyG) index serves as an alternative index for assessing insulin resistance (IR). The relationship between the TyG index and its combined indicators and sarcopenia remains insufficiently explored.AimTo investigate the ...
Xinyu Yu, Siqi Jiang, Zhiyu Chen, Keke Ren, Shan Li, Yetao Luo, Deqing Chen, Qinghua Zhao, Huanhuan Huang   +8 more
doaj   +1 more source

Sex as a biological variable in nonclinical studies: Bridging scientific rigor, animal welfare, and regulatory expectations

Animal Models and Experimental Medicine, EarlyView.
Sex as a biological variable (SABV) is a critical determinant of pharmacokinetics, pharmacodynamics, and toxicity in nonclinical studies. This review highlights how inappropriate neglect of sex differences compromises animal welfare, scientific reproducibility, and regulatory compliance.
Kenta Onuma, Masaki Watanabe, Nobuya Sasaki   +2 more
wiley   +1 more source

Hyperprolactinemia induced by hCG leads to metabolic disturbances in female mice [PDF]

, 2016
The metabolic syndrome is a growing epidemic; it increases the risk for diabetes, cardiovascular disease, fatty liver, and several cancers. Several reports have indicated a link between hormonal imbalances and insulin resistance or obesity.
Bonaventura, Maria Marta, Calandra, Ricardo Saul, Huhtaniemi, Ilpo T., Lux, Victoria Adela R., Poutanen, Matti, Ratner, Laura Daniela, Rulli, Susana Beatriz, Stevens, Guillermina   +7 more
core   +1 more source

Blood Lactate as a Prognostic Biomarker for Survival and Weight Loss in Amyotrophic Lateral Sclerosis: An Exploratory–Validation Study

Annals of Neurology, EarlyView.
Objective Lactate is increasingly recognized as an energy substrate, but its relevance to amyotrophic lateral sclerosis (ALS) remains unclear. We examined whether blood lactate is associated with survival and weight loss in ALS. Methods This retrospective study included an Australian exploratory cohort and a Japanese validation cohort with clinical ...
Ryutaro Nakamura, Frederik J. Steyn, Shuhei Kobashi, Nobuhiro Ogawa, Akihiro Kitamura, Isamu Yamakawa, Robert D. Henderson, Shyuan T. Ngo, Makoto Urushitani   +8 more
wiley   +1 more source