Results 161 to 170 of about 5,723,129 (297)

The influence of circadian variables on ecotoxicology metabolomics

Biological Reviews, EarlyView.
ABSTRACT Ecotoxicologists are using metabolomics increasingly to gain insight into toxicological mechanisms and sublethal effects of chemical exposures. Metabolomics offers a sensitive multi‐parameter approach that can detect biochemical responses not obvious using apical and behavioural endpoints.
Ryan I. Lester, David J. Beale, Anthony R. Carroll, Steven D. Melvin   +3 more
wiley   +1 more source

Loss of hepatic SMLR1 causes hepatosteatosis and protects against atherosclerosis due to decreased hepatic VLDL secretion

Hepatology, EarlyView., 2022
The role of SMLR1 in lipid metabolism (high fat + cholesterol diet in mice) Abstract Background and Aims The assembly and secretion of VLDL from the liver, a pathway that affects hepatic and plasma lipids, remains incompletely understood. We set out to identify players in the VLDL biogenesis pathway by identifying genes that are co‐expressed with the ...
Willemien van Zwol, Antoine Rimbert, Justina C. Wolters, Marieke Smit, Vincent W. Bloks, Niels J. Kloosterhuis, Nicolette C. A. Huijkman, Mirjam H. Koster, Umesh Tharehalli, Simon M. de Neck, Colin Bournez, Marceline M. Fuh, Jeroen Kuipers, Sujith Rajan, Alain de Bruin, Henry N. Ginsberg, Gerard J. P. van Westen, M. Mahmood Hussain, Ludger Scheja, Joerg Heeren, Philip Zimmerman, Bart van de Sluis, Jan Albert Kuivenhoven   +22 more
wiley   +1 more source

Development and validation of a machine learning-based sarcopenia prediction model using the triglyceride glucose–frailty index

Journal of International Medical Research
Objective Sarcopenia is a progressive skeletal muscle disorder characterized by declines in muscle mass and function. This study developed a novel composite biomarker, the triglyceride glucose–frailty index, which integrates metabolic and frailty-related
Wang Xiang, Houcheng Zhu, Xiandong Liu, Qingsong Wu   +3 more
doaj   +1 more source

Association Between Triglyceride-Glucose Index and Gout in Young Adults in China [PDF]

Cong Huang,1,2 Xiaodong Gu,3 Sudong Liu,3 Honghui Luo,2 Yiqun Luo,2 Yu Zhang1,2 1Meizhou Clinical Institute, Shantou University Medical College, Meizhou, 514000, People’s Republic of China; 2Department of General Medicine, Meizhou People′s Hospital ...
Huang C, Gu X, Zhang Y, Luo Y, Liu S, Luo H   +5 more
core  

Lipid droplet profiling during neutrophil differentiation by stimulated Raman scattering microscopy

Biotechnology Progress, EarlyView.
Abstract Lipid droplets (LDs) are dynamic organelles that serve as metabolic hubs and emerging regulators of immune cell fate. Although LDs have been implicated in immune regulation, how LD metabolism is remodeled during neutrophil differentiation and how stage‐specific LD dynamics shape mature neutrophil function remain poorly defined.
Ting‐Jung Sung, Bin Dong, Jingqiao Shen, Yan Tan, Chi Zhang, Xiaoping Bao   +5 more
wiley   +1 more source

Mitochondrial stress in advanced fibrosis and cirrhosis associated with chronic hepatitis B, chronic hepatitis C, or nonalcoholic steatohepatitis

Hepatology, EarlyView., 2022
Adaptive mitochondrial mechanisms allow mitochondrial resilience and prevent the worsening of fibrosis, while deregulation of these mechanisms promotes the progression from no/minimal‐mild (F0‐F2) fibrosis to advanced fibrosis and cirrhosis (F3‐F4). Abstract Background and Aims Hepatitis B virus (HBV) infection causes oxidative stress (OS) and alters ...
Dimitri Loureiro, Issam Tout, Stéphanie Narguet, Cheikh Mohamed Bed, Morgane Roinard, Ahmad Sleiman, Nathalie Boyer, Nathalie Pons‐Kerjean, Corinne Castelnau, Nathalie Giuly, Dorothy Tonui, Vassili Soumelis, Jamel El Benna, Patrick Soussan, Richard Moreau, Valérie Paradis, Abdellah Mansouri, Tarik Asselah   +17 more
wiley   +1 more source

Prognostic Value of the Triglyceride-Glucose Index Combined with Non-HDL-C/HDL-C Ratio for Predicting Coronary Microvascular Dysfunction in ACS Patients Post-PCI [PDF]

Sitong Hang,1,* Nan Tang,2,* Kangming Li,2 Qingdui Zhang,2 Ji Hao,2 Yan Zhang,2 Chunmei Qi2 1China Medical University, Shenyang, Liaoning, 110000, People’s Republic of China; 2Department of Cardiology, The Second Affiliated Hospital of Xuzhou ...
Hang S, Hao J, Tang N, Zhang Y, Li K, Qi C, Zhang Q   +6 more
core  

The Effect of the MTHFR C677T Genotype Polymorphism on the Efficacy of Folic Acid Treatment for Hyperhomocysteinemia and Cardiovascular Endothelial Function

Chronic Diseases and Translational Medicine, EarlyView.
Flowchart of patient enrollment. ABSTRACT Background Cardiovascular disease remains a major public health burden. This study aimed to investigate the effect of the methylenetetrahydrofolate reductase (MTHFR) C677T genotype on folic acid treatment response and cardiovascular endothelial function in patients with hyperhomocysteinemia (HHcy).
Xiaohui Dou, Xijuan Zhang, Liang Zeng, Liheng Zeng, Xiaoyan Hu, Xuhong Jiang, Yahui Wan, Mingxia Ge, Xiaoyan Huang   +8 more
wiley   +1 more source

Nicotinamide riboside and pterostilbene reduces markers of hepatic inflammation in NAFLD: A double‐blind, placebo‐controlled clinical trial

Hepatology, EarlyView., 2022
NRPT 1X reduces ALT and ceramide 14:0 in 65% of subjects as compared to only 28% in the placebo group. Abstract Background and Aims The prevalence of NAFLD is increasing globally and on a path to becoming the most frequent cause of chronic liver disease. Strategies for the prevention and treatment of NAFLD are urgently needed.
Ryan W. Dellinger, Holly E. Holmes, Tina Hu‐Seliger, Rodney W. Butt, Stephen A. Harrison, Dariush Mozaffarian, Oliver Chen, Leonard Guarente   +7 more
wiley   +1 more source

The triglyceride-glucose index and C-reactive protein-triglyceride-glucose index as surrogate markers of vascular stiffness in prediabetes: a cross-sectional study

BMC Cardiovascular Disorders
Prediabetes accelerates arterial stiffening, yet the optimal metabolic biomarker for vascular assessment remains undetermined. This study investigated the associations of the homeostasis model assessment of insulin resistance (HOMA-IR), triglyceride-glucose (TyG) index, and C-reactive protein-triglyceride-glucose index (CTI) with arterial stiffness in ...
Guorang Qiu, Xuhong Li, Li Jiang, Yanhua Zhou, Jiaojiao Liu, Kui Chen, Xiaoling Zhu, Yaqin Wang   +7 more
openaire   +2 more sources