Results 141 to 150 of about 5,723,129 (297)

Durable and Additive Disease Control at 52 Weeks With Ixekizumab Plus Tirzepatide Versus Ixekizumab Alone in Adults With Psoriatic Arthritis and Obesity or Overweight: Additional Results From a Randomized Clinical Trial

Arthritis &Rheumatology, EarlyView.
Objective Obesity or overweight occurs in 72% to 82% of individuals with psoriatic arthritis (PsA). Previous data revealed greater disease control with concomitant ixekizumab (IXE) and tirzepatide (TZP) versus IXE alone in adults with active PsA and obesity or overweight with at least one weight‐related comorbidity at the week 36 primary end point. The
Joseph F. Merola, Cynthia E. Kartman, Peter Fischer, Philip Mease, Alan Kivitz, Naveed Sattar, Laura C. Coates, Daniel Aletaha, Luna Sun, Yurong Chen, Ketan Marulkar, Natalia Bello, Anabela Cardoso, Mark C. Genovese, Alexis Ogdie   +14 more
wiley   +1 more source

Triglyceride-glucose (TyG) index combined with C-reactive protein outperforms the TyG index alone in predicting stroke in arthritis patients: a nationwide prospective cohort study

Lipids in Health and Disease
Background Arthritis patients exhibit a higher stroke risk, but effective predictive biomarkers are scarce. This research sought to examine and compare the associations between the triglyceride-glucose (TyG) index, its integration with C-reactive protein
Zhongwei Zhou, Jianshu Gao, Mingzhong Sun, Hongmei Chen, Hao Jin, Huixiang Ju   +5 more
doaj   +1 more source

Triglyceride-glucose index and triglyceride-glucose–body mass index as prognostic factors for early stage breast cancer patients receiving neoadjuvant chemotherapy

Translational Oncology
Background: Insulin resistance (IR) is closely associated with the risk of breast cancer. The triglyceride-glucose (TyG) index and the triglyceride-glucose–body mass index (TyG-BMI) are considered surrogate indicators of IR; however, their prognostic ...
Fucheng Li, Tian Gao, Zhaoting Li, He Dou, Yuling Ba, Siyuan Jia, Danli Luo, Min Xiao   +7 more
doaj   +1 more source

Comparative efficacy of GLP‐1 RA, tirzepatide and SGLT‐2 inhibitors in metabolic liver disease: A network meta‐analysis

British Journal of Clinical Pharmacology, EarlyView.
Aim Metabolic liver disease, including nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis, is a major cause of chronic liver dysfunction worldwide, creating an urgent need for effective treatments. This systematic literature review (SLR) and network meta‐analysis (NMA) systematically reviews and compares the efficacy and safety ...
Andrej Belančić, Christina Antza, Anastasios Poutachidis, Smaro Palaska, Elvira Meni Maria Gkrinia, Andrea Katrin Faour, Yusuf Ziya Sener, Seher Sener, Rehena Sultana   +8 more
wiley   +1 more source

Association between Heavy metals and triglyceride-glucose-related index: a mediation analysis of inflammation indicators

Lipids in Health and Disease
Background In cardiovascular diseases (CVD) and insulin resistance (IR), elevated blood lipids and glucose are common. These abnormalities accelerate atherosclerosis and may impair insulin signaling via oxidative stress and inflammation. The triglyceride-
Yitao Hu, Yuzhe Kong, Xinling Tian, Xinyi Zhang, Yu Zuo   +4 more
doaj   +1 more source

Cumulative estimated glucose disposal rate predicts frailty progression in Chinese adults with diabetes: a 9-year follow-up cohort study

Frontiers in Medicine
IntroductionFrailty is a common adverse outcome in diabetes that is linked to reduced quality of life and increased mortality and is strongly associated with insulin resistance.
Bin Zhao, Zhian Liang, Xiaojie Zhao, Xiangchen Dai   +3 more
doaj   +1 more source

Hemoglobin glycation index and triglyceride-glucose index are related to diabetic nephropathy

Cirugía y Cirujanos (English Edition)
Diabetic nephropathy (DN) is a significant complication of diabetes. Despite strict management of fasting plasma glucose (FPG), DN may progress to end-stage renal disease. HbA1c, the best biomarker for glycemic management, may differ in similar FPG. Hemoglobin glycation index (HGI) = HbA1c as determined minus HbA1c as predicted.
openaire   +2 more sources

Exposure‐adjusted safety and efficacy of GLP‐I and GLP‐1/GIP receptor agonists compared with non‐GLP‐I for weight management and type 2 diabetes: Based on FDA medical and statistical reports of 34 280 safety and 36 312 efficacy subjects

British Journal of Clinical Pharmacology, EarlyView.
Aims This work aimed to contextualize glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) and glucose‐dependent insulinotropic polypeptide (GIP) receptor agonists safety and efficacy regarding weight management (WM); we analysed Food and Drug Administration (FDA) Medical Reviews to analyse 14 medications using patient‐exposure year normalization and ...
Aishwarya Prasad, Anshu Arora, Arun Arora, Jeena Vaid, Arif Khan   +4 more
wiley   +1 more source

NAFLD‐related hepatocellular carcinoma: The growing challenge

Hepatology, EarlyView., 2022
Risk and protective factors for NAFLD‐related hepatocellular carcinoma Abstract Hepatocellular carcinoma (HCC) is a common cause of cancer‐related mortality and morbidity worldwide. With the obesity pandemic, NAFLD‐related HCC is contributing to the burden of disease exponentially.
Pir Ahmad Shah, Rashmee Patil, Stephen A. Harrison   +2 more
wiley   +1 more source

Association Between Triglyceride Glucose Index and Postherpetic Neuralgia in Patients with Acute Herpes Zoster: A Retrospective Study

Pain and Therapy
Introduction Insulin resistance (IR) is an important factor in the development of chronic pain. The triglyceride–glucose (TyG) index is a convenient measure of insulin resistance.
Ziwei Lu, Chengcheng Zhao, Tong Zhi, Huadong Ni, Ming Yao   +4 more
doaj   +1 more source