Decoding Blastocystis‐Driven Mechanisms in Gut Microbiota and Host Metabolism
Blastocystis, a prevalent gut microbe, interacts with the host through metabolic and immune pathways, influencing cardiometabolic health. This perspective explores its role in modulating short‐chain fatty acid production, tryptophan metabolism, and immune signaling, potentially impacting cholesterol absorption, glucose metabolism, and vascular health ...
Lei Deng, Kevin SW Tan
wiley +1 more source
Health Information and Social Security Entitlements [PDF]
This study examines whether new health information, obtained through medical screening, affects entitlements to Social Security benefits. Random assignment of information is derived from a unique feature of the Continuous National Health and Nutrition ...
Perry Singleton
core +1 more source
Hepatocellular carcinoma (HCC) cells under high‐fat environment constrain harmful reactive oxygen species (ROS) by enhancing glutathione synthesis though upregulating interferon stimulated gene 15 (ISG15). In this process, upregulated high mobility group A1 (HMGA1) enhances ISG15 transcription, upregulated ISG15 subsequently noncovalently binds with ...
Xinran Liu+21 more
wiley +1 more source
Effect of effective microorganisms on some biochemical parameters in broiler chicks [PDF]
This study was conducted to investigate the potential effect of effective microorganisms (EM) on some biochemical parameters which includes; glucose, cholesterol and triglycerides levels in addition to the levels of Alanine aminotransferase (ALT) and ...
S.K. Abd
doaj
Secondary Phenotype Analysis in Ascertained Family Designs: Application to the Leiden Longevity Study [PDF]
The case-control design is often used to test associations between the case-control status and genetic variants. In addition to this primary phenotype a number of additional traits, known as secondary phenotypes, are routinely recorded and typically associations between genetic factors and these secondary traits are studied too.
arxiv
Zur Kenntnis der Glycerinester der Benzoe‐ und Myristinsäure und über partielle Verseifung der Triglyceride [PDF]
A. Lipp, P. Miller
openalex +1 more source
MTCH2 Suppresses Thermogenesis by Regulating Autophagy in Adipose Tissue
This study demonstrates that MTCH2 acts as an evolutionarily conserved regulator of energy homeostasis across Drosophila, rodents, and humans. Adipose‐specific MTCH2 ablation enhances brown/beige adipose thermogenesis through Bcl‐2‐dependent autophagy, promoting energy expenditure and counteracting obesity‐associated metabolic disorders. These findings
Xin‐Yuan Zhao+17 more
wiley +1 more source
Central lipid detection and the regulation of feeding behavior
The modern abundance of energy-rich foods combined with a shift to more sedentary lifestyles has led to a thermodynamic imbalance in which excessive caloric intake and reduced energy expenditure account for the prevalence of obesity.
Cansell Céline, Luquet Serge
doaj +1 more source
Enhancing Metabolic Syndrome Prediction with Hybrid Data Balancing and Counterfactuals [PDF]
Metabolic Syndrome (MetS) is a cluster of interrelated risk factors that significantly increases the risk of cardiovascular diseases and type 2 diabetes. Despite its global prevalence, accurate prediction of MetS remains challenging due to issues such as class imbalance, data scarcity, and methodological inconsistencies in existing studies.
arxiv
High-dimensional confounding adjustment using continuous spike and slab priors [PDF]
In observational studies, estimation of a causal effect of a treatment on an outcome relies on proper adjustment for confounding. If the number of the potential confounders ($p$) is larger than the number of observations ($n$), then direct control for all potential confounders is infeasible.
arxiv