Results 11 to 20 of about 4,933 (206)

Development and Characterization of Trihexyphenidyl Orodispersible Minitablets: A Challenge to Fill the Therapeutic Gap in Neuropediatrics [PDF]

Pharmaceutics
Background: Trihexyphenidyl (THP) has been widely used for over three decades as pediatric pharmacotherapy in patients affected by segmental and generalized dystonia.
Camila Olivera, Oriana Boscolo, Cecilia Dobrecky, Claudia A. Ortega, Laura S. Favier, Valeria A. Cianchino, Sabrina Flor, Silvia Lucangioli   +7 more
doaj   +4 more sources

Muscarinic receptor drug trihexyphenidyl can alter growth of mesenchymal glioblastoma in vivo [PDF]

Frontiers in Pharmacology
Glioblastoma (GBM) is the most commonly occurring and most aggressive primary brain tumor. Transcriptomics-based tumor subtype classification has established the mesenchymal lineage of GBM (MES-GBM) as cancers with particular aggressive behavior and high
Renfei Du, Renfei Du, Ahmed Y. Sanin, Wenjie Shi, Bing Huang, Bing Huang, Ann-Christin Nickel, Andres Vargas-Toscano, Shuran Huo, Thomas Nickl-Jockschat, Claudia A. Dumitru, Wei Hu, Siyu Duan, I. Erol Sandalcioglu, Roland S. Croner, Joshua Alcaniz, Wolfgang Walther, Carsten Berndt, Ulf D. Kahlert   +18 more
doaj   +4 more sources

Efficacy of Trihexyphenidyl on Apraxia of Eyelid Opening in Parkinsonism: A Case Report. [PDF]

Cureus
Apraxia of eyelid opening (AEO) is occasionally seen in Parkinson’s disease (PD) or related diseases. However, many clinicians have trouble with the management of AEO by Parkinsonism.
Hayashi K, Asano R, Sato M, Nakaya Y, Suzuki A, Takaku N, Hayashi K, Kobayashi Y.   +7 more
europepmc   +4 more sources

A Novel Reduced Graphene Oxide Modified Carbon Paste Electrode for Potentiometric Determination of Trihexyphenidyl Hydrochloride in Pharmaceutical and Biological Matrices [PDF]

Sensors, 2021
A novel promising carbon paste electrode with excellent potentiometric properties was prepared for the analysis of trihexyphenidyl hydrochloride (THP), the acetylcholine receptor and an anticholinergic drug in real samples.
Josip Radić, Maša Buljac, Boštjan Genorio, Ema Gričar, Mitja Kolar   +4 more
doaj   +3 more sources

Protective role of coenzyme Q10 against trihexyphenidyl-induced pulmonary toxicity in Wistar rats [PDF]

BMC Pharmacology and Toxicology
Background Trihexyphenidyl (THP), an anticholinergic drug used to manage Parkinson’s disease and dystonia, has been associated with oxidative stress and metabolic disturbances, particularly affecting pulmonary function.
Joseph Gbenga Omole, Lydia Oluwatoyin Ajayi, Itunuoluwa Rachael Ajewole, Teniola Osholonge, Oyedayo Phillips Akano, Ayodeji Folorunsho Ajayi   +5 more
doaj   +3 more sources

Reversal of motor-skill transfer impairment by trihexyphenidyl and reduction of dorsolateral striatal cholinergic interneurons in Dyt1 ΔGAG knock-in mice

IBRO Neuroscience Reports, 2021
DYT-TOR1A or DYT1 early-onset generalized dystonia is an inherited movement disorder characterized by sustained muscle contractions causing twisting, repetitive movements, or abnormal postures.
Fumiaki Yokoi, Mai Tu Dang, Lin Zhang, Kelly M. Dexter, Iakov Efimenko, Shiv Krishnaswamy, Matthew Villanueva, Carly I. Misztal, Malinda Gerard, Patrick Lynch, Yuqing Li   +10 more
doaj   +3 more sources

Crystal structures of four organic salts of trihexyphenidyl at 90 K

Acta Crystallographica Section E: Crystallographic Communications, 2023
The syntheses and crystal structure studies of four organic salts of trihexyphenidyl, viz., trihexyphenidylium [1-(3-cyclohexyl-3-hydroxy-3-phenylpropyl)piperidin-1-ium] 4-nitrobenzoate, C20H32NO+·C7H4NO4− (I), trihexyphenidylium 4-hydroxybenzoate ...
Vinaya, Yeriyur B. Basavaraju, Hemmige S. Yathirajan, Sean Parkin   +3 more
doaj   +2 more sources

Formulation and evaluation of bi-layer floating tablets of ziprasidone HCl and trihexyphenidyl HCl [PDF]

Brazilian Journal of Pharmaceutical Sciences, 2011
The purpose of this research study was to establish ziprasidone HCl NR 40 mg and trihexyphenidyl HCl SR 4mg in the form of bi-layer sustained release floating tablets.
Sathis Kumar Dinakaran, Santhos Kumar, David Banji, Harani Avasarala, Venkateshwar Rao   +4 more
doaj   +2 more sources

Method Development and Validation by UV Spectrophotometric Analysis and RP-HPLC Method for Simultaneous Estimation of Risperidone and Trihexyphenidyl

International Journal of Drug Delivery Technology, 2022
Risperidone is of the chemical class of benzisoxazole derivatives. Risperidone chemically name is 3-[2-[4-(6-fluoro-1, 2-benzisoxazol-3-yl)-1- piperidinyl] ethyl]-6, 7, 8, 9-tetrahydro- 2-methyl-4H-pyrido [1, 2-a] pyrimidine-4-one.
Rupsi ., Rakesh Kumar
semanticscholar   +2 more sources

A Novel WARS2 Mutation in a Swiss Family With Predominant Generalized Dystonia Responsive to Trihexyphenidyl

Journal of Clinical Neurology, 2023
Dear Editor, Biallelic mutations of WARS2, which encodes the mitochondrial tryptophanyl-tRNA synthetase, were first described in an intellectual disability consanguineous Iranian family in 2017.1 Subsequent reports described a broad phenotype of patients
V. Mihaylova, Y. Hérenger, Tobias Bethge, S. Bohlhalter   +3 more
semanticscholar   +2 more sources