Results 61 to 70 of about 94,783 (336)

Thyroxine differentially modulates the peripheral clock: lessons from the human hair follicle [PDF]

, 2015
The human hair follicle (HF) exhibits peripheral clock activity, with knock-down of clock genes (BMAL1 and PER1) prolonging active hair growth (anagen) and increasing pigmentation.
Farjo, Bessam, Farjo, Nilofer, Hardman, Jonathan A., Haslam, Iain S., Paus, Ralf   +4 more
core   +4 more sources

Fe‐S Protein FDX1 Triggers Tumor‐Intrinsic Innate Immunity via Mitochondrial Nucleic Acids Release to Orchestrate Ferroptosis in CCRCC

Advanced Science, EarlyView.
Restoration of the mitochondrial Fe–S protein FDX1 suppresses clear cell renal cell carcinoma by coupling ferroptosis with tumor‐intrinsic innate immune activation. FDX1 induces mitochondrial dysfunction and mtDNA/mt‐dsRNA release, activating cGAS–STING and RIG‐I/MDA5–MAVS signaling to elicit type I interferon responses, thereby promoting antigen ...
Xing Huang, Shaoqing Yu, Wenjie Wei, Wen Tao, Tianwei Cai, Lequan Wen, Jiali Ye, Chi Zhang, Huayi Feng, Senming Cao, Baojun Wang, Xin Ma, Yan Huang, Xu Zhang   +13 more
wiley   +1 more source

Resting energy expenditure is lower in Japanese female athletes with menstrual disorders than in eumenorrheic athletes

Journal of Physical Fitness and Sports Medicine, 2022
Menstrual disorders are health problems in female athletes. It has also been reported that amenorrhea can lead to metabolic suppression. However, studies regarding resting energy expenditure (REE) in Japanese female athletes with menstrual disorders are ...
Kuniko Moto, Mika Goshozono, Suguru Torii, Akira Namba, Motoko Taguchi   +4 more
doaj   +1 more source

Mapping molluscan endocrinology: a systematic and critical appraisal

Biological Reviews, EarlyView.
ABSTRACT Historically, a vertebrate‐centric paradigm has framed our interpretation of molluscan endocrinology, with considerable research focusing on vertebrate‐type steroid hormones (e.g. oestrogens, testosterone). However, contradictory evidence on the occurrence of vertebrate‐type steroid hormones in molluscan tissues, and a lack of the specific ...
Konstantinos Panagiotidis, Thomas H. Miller, Olwenn V. Martin, Alice Baynes   +3 more
wiley   +1 more source

l-Triiodothyronine Aminotransferase

Journal of Biological Chemistry, 1973
Abstract An enzyme which catalyzes the transamination of l-triiodothyronine and of halogenated and nitrated tyrosines has been detected in the soluble fraction of a variety of rabbit organs. Kidney and liver had the highest specific activities of this enzyme which was isolated from the latter source.
R L, Soffer, P, Hechtman, M, Savage
openaire   +2 more sources

Thyroid hormones correlate with field metabolic rate in ponies, Equus ferus caballus [PDF]

, 2016
Acknowledgments The authors thank Jürgen Dörl for technical help and for taking care of the animals and Peter Thompson for technical assistance with the doubly labelled water analysis.
Brinkmann, Lea, Gerken, Martina, Hambly, Catherine, Riek, Alexander, Speakman, John R   +4 more
core   +1 more source

A multipart phase 1 study of the safety, pharmacodynamics and pharmacokinetics of ALG‐055009, a novel thyroid hormone receptor beta (THR‐β) agonist for metabolic dysfunction‐associated steatohepatitis (MASH), in healthy participants

Clinical Pharmacology in Drug Development, EarlyView.
Abstract ALG–055009 is an oral thyroid hormone receptor beta (THR‐β) agonist being evaluated for treating metabolic dysfunction–associated steatohepatitis (MASH). This study evaluated the safety, tolerability, pharmacokinetics, and pharmacodynamics of ALG‐055009 and bioavailability/food effect.
Hakim Charfi, Benedetta Massetto, Megan Fitzgerald, Kha Le, Stanley Wang, Ifong Kan‐Eng, Meenakshi Venkatraman, Naqvi Mohammad, Lawrence Blatt, Tse‐I Lin, Sushmita M. Chanda, John Fry   +11 more
wiley   +1 more source

Water pipe smoking affects young females and males differently with some effects on immune system cells, but none for C-reactive protein, thyroid hormones, and vitamin D

Journal of Pharmacy and Bioallied Sciences, 2020
Introduction: Water pipe smoking (WPS) is a major health threat leading to higher mortality, morbidity, and incidence of many diseases, such as inflammatory, respiratory and cardiovascular diseases; and cancers.
Sawsan H Mahassni, Khloud A Alajlany
doaj   +1 more source

Goiter frequency is more strongly associated with gastric adenocarcinoma than urine iodine level [PDF]

, 2013
Purpose: We designed our study to evaluate the hypothesis that gastric cancer is correlated with iodine deficiency or thyroid dysfunction. Materials and Methods: We investigated the total body iodine reserve, thyroid function status and autoimmune ...
Adabi, K., Haghpanah, V., Hatami, E., Heshmat, R., Jahangirrad, A., Keshtkar, A., Kia, A., Larijani, B., Nabizadeh, R., Rohani, D., Roshandel, G., Semnani, S., Tabaeizadeh, M.   +12 more
core   +1 more source

Association of Gestational Free and Total Triiodothyronine With Gestational Hypertension, Preeclampsia, Preterm Birth, and Birth Weight: An Individual Participant Data Meta-analysis [PDF]

, 2023
Arash Derakhshan, Tuija Männistö, Liangmiao Chen, J. Osinga, Ghalia Ashoor, Xuemian Lu, Sofie Bliddal, Fangbiao Tao, Suzanne J. Brown, Bijay Vaidya, Andrew T. Hattersley, Sachiko Itoh, Polina Popova, Ashraf Aminorroaya, Reiko Kishi, Maryam Kianpour, Elena Vasukova, Abel López‐Bermejo, Emily Oken, Leda Chatzi, Marina Vafeiadi, Wichor M. Bramer, Judit Bassols, Aitana Lertxundi, Ana Fernández‐Somoano, Paula Carrasco, Juha Auvinen, Kun Huang, Ulla Feldt‐Rasmussen, Elena Grineva, Erik K. Alexander, Elizabeth N. Pearce, Layal Chaker, John P. Walsh, Robin P. Peeters, Mònica Guxens, Eila Suvanto, K. H. Nicolaides, Tim I.M. Korevaar   +38 more
openalex   +1 more source