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Engineering Antibodies into Targeted Chimeras: From Recognition Modules to Programmable Degraders
Advanced Science, EarlyView.Antibody can be engineered into diverse lysosome‐targeting chimeras that convert target recognition into active degradation. By coupling antibody binding with recruited receptors, encoded domains, conjugated ligands, or nanoparticle scaffolds, these antibody‐associated targeted chimeras (AbTACs) platforms direct extracellular and membrane proteins ...
Kaige Chen, Quanyin Hu
wiley +1 more source
Molecular Design Strategies for High‐Voltage Organic Cathodes
Advanced Energy Materials, EarlyView.This work proposes molecular engineering strategies for high‐voltage organic cathode materials for Li‐ion batteries: (1) increase Li‐O coordination number (CN), (2) achieve a greater increase in aromaticity upon reduction (∆Aromaticity), and (3) add an electron‐withdrawing group (EWG), through a combined experimental and computational study on reported
Sungil Hong +8 more
wiley +1 more source
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The role of TRIM family proteins in autophagy, pyroptosis, and diabetes mellitus
Cell Biology International, 2021The ubiquitin‐proteasome system, which is one of the systems for cell protein homeostasis and degradation, happens through the ordered and coordinated action of three types of enzymes, E1 ubiquitin‐activating enzyme, E2 ubiquitin‐carrier enzyme, E3 ...
Yanbo Li, Tingting Wan
exaly +2 more sources
The interplay between viruses and TRIM family proteins
Reviews in Medical Virology, 2019Novel therapeutic options are urgently needed to improve the global treatment of viral infections. Tripartite motif (TRIM) family proteins are involved in various biological and cellular functions including differentiation, development, proliferation ...
Muhammad Idrees, Amjad Ali
exaly +2 more sources
TRIM Family Proteins: Roles in Autophagy, Immunity, and Carcinogenesis
Trends in Biochemical Sciences, 2017Shigetsugu Hatakeyama
exaly +2 more sources
The translational values of TRIM family in pan-cancers: From functions and mechanisms to clinics
Pharmacology and Therapeutics, 2021Xiangqian Guo +2 more
exaly +2 more sources
Diabetes, obesity and metabolism, 2023
Emerging evidence suggests that the ubiquitin‐mediated degradation of insulin‐signalling‐related proteins may be involved in the development of insulin resistance and its related disorders.
Jianrong Chen +3 more
semanticscholar +1 more source
Emerging evidence suggests that the ubiquitin‐mediated degradation of insulin‐signalling‐related proteins may be involved in the development of insulin resistance and its related disorders.
Jianrong Chen +3 more
semanticscholar +1 more source
TRIM family proteins: retroviral restriction and antiviral defence
Nature Reviews Microbiology, 2005Sébastien Nisole +2 more
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Regulation of NLRP3/TRIM family signaling in gut inflammation and colorectal cancer.
Biochimica et biophysica acta. Reviews on cancerCRC (Colorectal cancer) ranks among the most prevalent tumors in humans and remains a leading cause of cancer-related mortality worldwide. Numerous studies have highlighted the connection between inflammasome over-activation and the initiation and ...
Bibhashee Mohapatra +3 more
semanticscholar +1 more source
A trove of antiviral TRIM family E3 ligases in reptiles
bioRxivScaled reptiles (squamates) naturally encounter orthoflaviviruses and in some cases robustly resist infection. To identify antiviral defenses encoded in reptile genomes, we screened a green iguana cDNA library and discovered a reptilian TRIM-family E3 ...
Ian N. Boys, Meghan R. Quinlan, N. Elde
semanticscholar +1 more source