Results 101 to 110 of about 5,785,343 (209)

The mammalian TRIM-NHL protein TRIM71/LIN-41 is a repressor of mRNA function [PDF]

, 2016
TRIM-NHL proteins are conserved regulators of development and differentiation but their molecular function has remained largely elusive. Here, we report an as yet unrecognized activity for the mammalian TRIM-NHL protein TRIM71 as a repressor of mRNAs. We
Filipowicz, Witold, Gaidatzis, Dimos, Loedige, Inga, Meister, Gunter, Sack, Ragna   +4 more
core  

Molecular mechanism of influenza A NS1-mediated TRIM25 recognition and inhibition [PDF]

, 2018
RIG-I is a viral RNA sensor that induces the production of type I interferon (IFN) in response to infection with a variety of viruses. Modification of RIG-I with K63-linked poly-ubiquitin chains, synthesised by TRIM25, is crucial for activation of the ...
Cusack, S, Haubrich, K, Hennig, J, Koliopoulos, MG, Kowalinski, E, Lethier, M, Martin, SR, Reis E Sousa, C, Rittinger, K, Stevens, RV, Van der Veen, AG   +10 more
core   +2 more sources

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Association of the TRIM family protein with survival outcomes and clinicopathological features in colorectal cancer: a systematic review and meta-analysis

BMC Cancer
Background The tripartite motif (TRIM) proteins have been reported to play crucial roles in various malignancies. However, the clinical significance of TRIM proteins in colorectal cancer (CRC) remains controversial.
Ying Wu, Chen Chen, Xian Hua, Chunhua Zhao, Han Min   +4 more
doaj   +1 more source

Enterovirus 71 induces degradation of TRIM38, a potential E3 ubiquitin ligase

Virology Journal, 2011
Background The tripartite motif (TRIM) proteins are a family of more than 70 members in human. However, only a few of them have been well studied. The TRIM proteins contain the conserved RING, B-box, coiled-coil, and SPRY domains, most of which are ...
Wang Jianwei, Xue Qinghua, Sun Zhenmin, Zhou Zhuo, Lei Xiaobo, Liu Xinlei, Hung Tao   +6 more
doaj   +1 more source

Global Transcriptomic Profiling of Bovine Endometrial Immune Response In Vitro. II. Effect of Bovine Viral Diarrhea Virus on the Endometrial Response to Lipopolysaccharide [PDF]

, 2015
Infection with noncytopathic bovine viral diarrhea virus (ncpBVDV) is associated with uterine disease and infertility. This study investigated the influence of ncpBVDV on immune functions of the bovine endometrium by testing the response to bacterial ...
Abudureyimu, A, Anstaett, O L, Brownlie, J, Cheng, Z R, Fouladi-Nashta, A A, Oguejiofor, C F, Wathes, D C   +6 more
core   +2 more sources

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Structural and biochemical insights into small RNA 3' end trimming by Arabidopsis SDN1. [PDF]

, 2018
A family of DEDDh 3'→5' exonucleases known as Small RNA Degrading Nucleases (SDNs) initiates the turnover of ARGONAUTE1 (AGO1)-bound microRNAs in Arabidopsis by trimming their 3' ends. Here, we report the crystal structure of Arabidopsis SDN1 (residues 2-
Cao, Chunyang, Chen, Jiayi, Chen, Xuemei, Gan, Jianhua, Gu, Jiaqi, Huang, Ying, Liu, Li, Ma, Jinbiao, Ruan, Wenjie, You, Chenjiang, Zhang, Lu   +10 more
core   +2 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Co-Emergence of Specialized Endothelial Cells from Embryonic Stem Cells. [PDF]

, 2018
A well-formed and robust vasculature is critical to the health of most organ systems in the body. However, the endothelial cells (ECs) forming the vasculature can exhibit a number of distinct functional subphenotypes like arterial or venous ECs, as well ...
Douglas, Simone A, Fan, Yuhong, Kumar, Ashwath, Lin, Zhiqiang, Madfis, Nicole, McCloskey, Kara E, Platt, Manu O   +6 more
core   +1 more source