Results 131 to 140 of about 5,785,343 (209)

Evolution of a TRIM5-CypA Splice Isoform in Old World Monkeys [PDF]

, 2011
The TRIM family proteins share a conserved arrangement of three adjacent domains, an N-terminal RING domain, followed by one or two B-boxes and a coiled-coil, which constitutes the tripartite-motif for which the family is named. However, the C-termini of
Farzan, Michael Reynolds, Hall, Laura R, Johnson, Welkin Eric, Kirmaier, Andrea, Newman, Ruchi M., O'Neil, Shawn P., Pery, Erez, Pozzi, Lu-Ann   +7 more
core   +1 more source

Viral Evolution and Adaptation as a Multivariate Branching Process

, 2013
In the present work we analyze the problem of adaptation and evolution of RNA virus populations, by defining the basic stochastic model as a multivariate branching process in close relation with the branching process advanced by Demetrius, Schuster and ...
Antoneli, Fernando, Bosco, Francisco, Castro, Diogo, Janini, Luiz Mário Ramos, Mondaini, R. P.   +4 more
core   +1 more source

Analysis of B cell selection mechanisms in the adaptive immune response [PDF]

, 2005
The essential task of a germinal centre reaction is the selection of those B cells that bind the antigen with high affinity. The exact mechanisms of B cell selection is still unknown and rather difficult to be accessed in experiment.
Iber, D., Maini, P. K., Meyer-Hermann, M. E.   +2 more
core  

The antiviral spectra of TRIM5α orthologues and human TRIM family proteins against lentiviral production.

PLoS ONE, 2011
BackgroundRhesus monkey TRIM5α (TRIM5αrh) recognizes the incoming HIV-1 core through its C-terminal B30.2(PRYSPRY) domain and promotes its premature disassembly or degradation before reverse transcription.
Seiga Ohmine, Ryuta Sakuma, Toshie Sakuma, Tayaramma Thatava, Hiroaki Takeuchi, Yasuhiro Ikeda   +5 more
doaj   +1 more source

The critical role of TRIM protein family in intervertebral disc degeneration: mechanistic insights and therapeutic perspectives

Frontiers in Cell and Developmental Biology
Intervertebral disc degeneration (IVDD) is a leading cause of chronic back pain, contributing significantly to reduced quality of life and global public health burdens.
Shangze Li, Wenli Jiang, Fei Chen, Jiao Qian, Jun Yang   +4 more
doaj   +1 more source

Systematic alteration of ATAC-seq for profiling open chromatin in cryopreserved nuclei preparations from livestock tissues. [PDF]

, 2020
The use of Assay for Transposase-Accessible Chromatin (ATAC-seq) to profile chromatin accessibility has surged over the past years, but its applicability to tissues has been very limited.
Chanthavixay, G, Delany, ME, Halstead, MM, Kern, C, Ross, PJ, Saelao, P, Wang, Y, Zhou, H   +7 more
core   +1 more source

Analysis of the impact of TRIM5 polymorphism on retroviral replication [PDF]

This project aims to improve the SIV/rhesus macaques animal model for AIDS. TRIM5α is an antiviral molecule expressed in mammals including rhesus macaques.
Maplanka, Charlotte
core  

Characterization of a monoclonal antibody that induces the acrosome reaction of sea urchin sperm. [PDF]

, 1987
A monoclonal antibody, J18/29, induces the acrosome reaction (AR) in spermatozoa of the sea urchin Strongylocentrotus purpuratus. J18/29 induces increases in both intracellular Ca2+ and intracellular pH similar to those occurring upon induction of the AR
Ebina, Y, Meinhof, CG, Schackmann, RW, Trimmer, JS, Vacquier, VD   +4 more
core  

Trimming proline dehydrogenase : protein and cofactor minimization

, 2017
Proline is one of the proteinogenic amino acids and one of the most abundant amino acids in the cell. Next to serving as one of the non-essential amino acids, proline also has a central role in metabolism. In Chapter 1, the different functions of this imino acid are described, as well as the proline metabolic enzymes. The focus is on the enzyme proline
openaire   +3 more sources

Profiled deviance for the multivariate linear mixed-effects model fitting

, 2017
This paper focuses on the multivariate linear mixed-effects model, including all the correlations between the random effects when the marginal residual terms are assumed uncorrelated and homoscedastic with possibly different standard deviations.
Adjakossa, Eric, Nuel, Grégory
core