Results 161 to 170 of about 5,785,343 (209)
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Nature Reviews Cancer, 2011
Emerging clinical evidence shows that the deregulation of ubiquitin-mediated degradation of oncogene products or tumour suppressors is likely to be involved in the aetiology of carcinomas and leukaemias. Recent studies have indicated that some members of the tripartite motif (TRIM) proteins (one of the subfamilies of the RING type E3 ubiquitin ligases)
Shigetsugu Hatakeyama
exaly +4 more sources
Emerging clinical evidence shows that the deregulation of ubiquitin-mediated degradation of oncogene products or tumour suppressors is likely to be involved in the aetiology of carcinomas and leukaemias. Recent studies have indicated that some members of the tripartite motif (TRIM) proteins (one of the subfamilies of the RING type E3 ubiquitin ligases)
Shigetsugu Hatakeyama
exaly +4 more sources
The Role of TRIM Proteins in Vascular Disease.
Current Vascular Pharmacology, 2023There are more than 80 different tripartite motifs (TRIM) proteins within the E3 ubiquitin ligase subfamily, including proteins that regulate intracellular signaling, apoptosis, autophagy, proliferation, inflammation, and immunity through the ...
Xinxin Chen, Xiaolong Chen
semanticscholar +3 more sources
TRIM proteins in breast cancer: Function and mechanism.
Biochemical and Biophysical Research Communications, 2022Breast cancer is the most prevalent malignancy in the world, and despite tremendous progress in current treatment strategies, recurrence, metastasis and drug resistance of breast cancer remain the major causes of death in patients. Tripartite motif (TRIM)
Xin Bai, Jianming Tang
semanticscholar +3 more sources
Fish antiviral tripartite motif (TRIM) proteins
Fish & Shellfish Immunology, 2019Tripartite motif (TRIM) family or RBCC proteins comprises characteristic zinc-binding domains (a RING (R), a B-box type 1 (B1) and a B-box type 2 (B2)) and coiled-coil (CC) domain followed by a C-terminus variable domain. There are about 80 different TRIM proteins in human, but more than 200 in zebrafish with several large gene expansions (ftr >70 ...
C. Langevin, J. Levraud, P. Boudinot
semanticscholar +4 more sources
The Role of TRIM Proteins in Antiviral Defense
Highlights in Science Engineering and Technology, 2023The Tripartite motif (TRIM) protein family is classified among a cohort of E3 ubiquitin ligase families. A large percentage of TRIM proteins are E3 ubiquitin ligase active and take part in a number of cellular functions.
Yilin Liu
semanticscholar +1 more source
Current molecular medicine, 2022
Deregulation of ubiquitin-mediated degradation of oncogene products or tumor suppressors appears to be implicated in the genesis of carcinomas, according to new clinical findings. Conferring to recent research, some members of the tripartite motif (TRIM)
S. Ray, S. Mukherjee
semanticscholar +1 more source
Deregulation of ubiquitin-mediated degradation of oncogene products or tumor suppressors appears to be implicated in the genesis of carcinomas, according to new clinical findings. Conferring to recent research, some members of the tripartite motif (TRIM)
S. Ray, S. Mukherjee
semanticscholar +1 more source
Lentiviral Effector Pathways of TRIM Proteins
DNA and Cell Biology, 2014The human tripartite motif (TRIM) family, composed of more than 77 members, encompasses an emerging group of innate antiviral factors. Most TRIM proteins are characterized by being E3 ubiquitin ligases, but also engage in specific interactions with a variety of cellular and viral partners.
F. Turrini, A. Di Pietro, E. Vicenzi
semanticscholar +3 more sources
TRIM family proteins: retroviral restriction and antiviral defence
Nature Reviews Microbiology, 2005Members of the tripartite motif (TRIM) protein family are involved in various cellular processes, including cell proliferation, differentiation, development, oncogenesis and apoptosis. Some TRIM proteins display antiviral properties, targeting retroviruses in particular. The potential activity of TRIM19, better known as promyelocytic leukaemia protein,
Sébastien Nisole, Jonathan P Stoye
exaly +3 more sources
2012
TRIM proteins play important roles in several patho-physiological processes. Their common activity within the ubiquitylation pathway makes them amenable to a number of diverse biological roles. Many of the TRIM genes are highly and sometimes specifically expressed during embryogenesis, it is therefore not surprising that several of them might be ...
Francesca, Petrera, Germana, Meroni
openaire +2 more sources
TRIM proteins play important roles in several patho-physiological processes. Their common activity within the ubiquitylation pathway makes them amenable to a number of diverse biological roles. Many of the TRIM genes are highly and sometimes specifically expressed during embryogenesis, it is therefore not surprising that several of them might be ...
Francesca, Petrera, Germana, Meroni
openaire +2 more sources
Structural determinants of TRIM protein function
Biochemical Society Transactions, 2017Tripartite motif (TRIM) proteins constitute one of the largest subfamilies of Really Interesting New Gene (RING) E3 ubiquitin ligases and contribute to the regulation of numerous cellular activities, including innate immune responses. The conserved TRIM harbours a RING domain that imparts E3 ligase activity to TRIM family proteins, whilst a variable C ...
Diego, Esposito +2 more
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