Results 171 to 180 of about 5,785,343 (209)
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Experimental Cell Research
The tripartite motif (TRIM) proteins are well-studied as essential modulators of many processes, including the modulation of several pathways linked to immunological reactions. Most TRIM family members can polyubiquitinate the targeted proteins by acting
S. Uthirapathy +9 more
semanticscholar +1 more source
The tripartite motif (TRIM) proteins are well-studied as essential modulators of many processes, including the modulation of several pathways linked to immunological reactions. Most TRIM family members can polyubiquitinate the targeted proteins by acting
S. Uthirapathy +9 more
semanticscholar +1 more source
2012
Some members of the tripartite motif (TRIM/RBCC) protein family are thought to be important regulators of carcinogenesis. This is not surprising as the TRIM proteins are involved in several biological processes, such as cell growth, development and cellular differentiation and alteration of these proteins can affect transcriptional regulation, cell ...
Valeria, Cambiaghi +5 more
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Some members of the tripartite motif (TRIM/RBCC) protein family are thought to be important regulators of carcinogenesis. This is not surprising as the TRIM proteins are involved in several biological processes, such as cell growth, development and cellular differentiation and alteration of these proteins can affect transcriptional regulation, cell ...
Valeria, Cambiaghi +5 more
openaire +2 more sources
A protein to trim too-long telomeres
Science, 2017Telomeres Telomeres cap the ends of linear eukaryotic chromosomes. They consist of multiple copies of short DNA repeats. The length of telomeres is important to genome stability; if they become too short, individuals can become prone to cancer and premature aging. Li et al.
Guy, Riddihough, Stella M, Hurtley
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Many Faces of TRIM Proteins on the Road from Pluripotency to Neurogenesis
Stem Cells and Development, 2020Tripartite motif (TRIM) proteins participate in numerous biological processes. They are the key players in immune system and are involved in the oncogenesis.
V. Nenasheva, V. Tarantul
semanticscholar +1 more source
Diabetes, obesity and metabolism, 2023
Emerging evidence suggests that the ubiquitin‐mediated degradation of insulin‐signalling‐related proteins may be involved in the development of insulin resistance and its related disorders.
Jianrong Chen +3 more
semanticscholar +1 more source
Emerging evidence suggests that the ubiquitin‐mediated degradation of insulin‐signalling‐related proteins may be involved in the development of insulin resistance and its related disorders.
Jianrong Chen +3 more
semanticscholar +1 more source
The role of TRIM family proteins in autophagy, pyroptosis, and diabetes mellitus
Cell Biology International, 2021The ubiquitin‐proteasome system, which is one of the systems for cell protein homeostasis and degradation, happens through the ordered and coordinated action of three types of enzymes, E1 ubiquitin‐activating enzyme, E2 ubiquitin‐carrier enzyme, E3 ...
T-T Wan, Xiu Li, Yanbo Li
semanticscholar +1 more source
2012
Genomics and Evolution of the TRIM Gene Family.- The TRIpartite Motif: Structure and Function.- TRIM Proteins as RING Finger E3 Ubiquitin Ligases.- PML Nuclear Bodies and Other TRIM-Defined Subcellular Compartments.- TRIM Involvement in Transcriptional Regulation.- TRIM Proteins in Cancer.- TRIM Proteins and the Innate Immune Response to Viruses.- The ...
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Genomics and Evolution of the TRIM Gene Family.- The TRIpartite Motif: Structure and Function.- TRIM Proteins as RING Finger E3 Ubiquitin Ligases.- PML Nuclear Bodies and Other TRIM-Defined Subcellular Compartments.- TRIM Involvement in Transcriptional Regulation.- TRIM Proteins in Cancer.- TRIM Proteins and the Innate Immune Response to Viruses.- The ...
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TRIM Proteins: Another Class of Viral Victims
Science Signaling, 2010Influenza A virus suppresses the host interferon response by interfering with the RIG-I and TRIM25 antiviral molecules.
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The interplay between viruses and TRIM family proteins
Reviews in Medical Virology, 2019SummaryNovel therapeutic options are urgently needed to improve the global treatment of viral infections. Tripartite motif (TRIM) family proteins are involved in various biological and cellular functions including differentiation, development, proliferation, oncogenesis, innate immunity, and viral autophagy.
Ramisha Khan +3 more
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MiRNA need a TRIM regulation of miRNA activity by Trim-NHL proteins.
Advances in experimental medicine and biology, 2011Trim-NHL proteins are defined by RING, B-Box and Coiled-coil protein motifs (referred to collectively as the Trim domain) coupled to an NHL domain. The C. elegans, D. melanogaster, mouse and human Trim-NHL proteins are potential and in several cases confirmed, E3 ubiquitin ligases.
F Gregory, Wulczyn +3 more
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