Results 41 to 50 of about 5,785,343 (209)
Tumor suppressor p53 cross-talks with TRIM family proteins
Genes and Diseases, 2021 p53 is a key tumor suppressor. As a transcription factor, p53 accumulates in cells in response to various stress signals and selectively transcribes its target genes to regulate a wide variety of cellular stress responses to exert its function in tumor ...
Juan Liu +4 more
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Substrate recognition by TRIM and TRIM-like proteins in innate immunity
Seminars in Cell & Developmental Biology, 2021 TRIM (Tripartite motif) and TRIM-like proteins have emerged as an important class of E3 ligases in innate immunity. Their functions range from activation or regulation of innate immune signaling pathway to direct detection and restriction of pathogens.
Wang, Hai-Tao, Hur, Sun
openaire +2 more sources
TRIM proteins regulate autophagy and can target autophagic substrates by direct recognition. [PDF]
Dev Cell, 2014 Mandell MA +13 more
europepmc +2 more sources
Exploration of the TRIM fold of MuRF1 using EPR reveals a canonical antiparallel structure and extended COS-box [PDF]
, 2019 MuRF1 (TRIM63) is a RING-type E3 ubiquitin ligase with a predicted tripartite TRIM fold. TRIM proteins rely upon the correct placement of an N-terminal RING domain, with respect to C-terminal, specific substrate-binding domains.
Cafiso, David S. +6 more
core +3 more sources
Resonance Energy Transfer [PDF]
, 2015 Resonance energy transfer, also known as Förster- or fluorescence- resonance energy transfer, or electronic energy transfer, is a photonic process whose relevance in many major areas of science is reflected both by a wide prevalence of the effect and ...
Andrews, David +3 more
core +1 more source
TRIM proteins as trim tabs for the homoeostasis [PDF]
Journal of Biochemistry, 2013 The tripartite motif (TRIM) or RBCC proteins are characterized by the TRIM composed of a RING finger, B-box and coiled-coil domains. TRIM proteins often play roles in the post-translational protein modification, including ubiquitylation and other ubiquitin-like modifications.
openaire +2 more sources
Genome Biology, 2019 Trim-Away is a recent technique to rapidly deplete a protein from any cell type. Guided by antibodies, TRIM21 selects proteins for destruction. However, the applicability of this method in model organisms has not been investigated.
Xiao Chen +7 more
doaj +1 more source
Origin and diversification of TRIM ubiquitin ligases. [PDF]
PLoS ONE, 2012 Most proteins of the TRIM family (also known as RBCC family) are ubiquitin ligases that share a peculiar protein structure, characterized by including an N-terminal RING finger domain closely followed by one or two B-boxes.
Ignacio Marín
doaj +1 more source
To TRIM the Immunity: From Innate to Adaptive Immunity
Frontiers in Immunology, 2020 The tripartite motif (TRIM) proteins have been intensively studied as essential modulators in various biological processes, especially in regulating a wide range of signaling pathways involved in immune responses.
Wenyong Yang +3 more
doaj +1 more source
Adaptive response of neonatal sepsis-derived Group B Streptococcus to bilirubin [PDF]
, 2018 This work was funded by the Neonatal Unit Endowment Fund, Aberdeen Maternity Hospital. RH is funded by a career researcher fellowship from NHS Research Scotland. SG was funded by the MRC Flagship PhD programme.
Berry, Susan +10 more
core +4 more sources