Truncation of TRIM5 in the Feliformia explains the absence of retroviral restriction in cells of the domestic cat [PDF]
, 2009 TRIM5[alpha] mediates a potent retroviral restriction phenotype in diverse mammalian species. Here, we identify a TRIM5 transcript in cat cells with a truncated B30.2 capsid binding domain and ablated restrictive function which, remarkably, is conserved ...
Hosie, Margaret J. +5 more
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“Trim”ming PolyQ proteins with engineered PML [PDF]
Biotechnology and Bioengineering, 2019 AbstractProtein abnormalities are the major cause of neurodegenerative diseases such as spinocerebellar ataxia (SCA). Protein misfolding and impaired degradation leads to the build‐up of protein aggregates inside the cell, which may further cause cellular degeneration.
Neha Dhar +3 more
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Adenovirus type 5 E4 Orf3 protein targets promyelocytic leukaemia (PML) protein nuclear domains for disruption via a sequence in PML isoform II that is predicted as a protein interaction site by bioinformatic analysis [PDF]
, 2009 Human adenovirus type 5 infection causes the disruption of structures in the cell nucleus termed promyelocytic leukaemia (PML) protein nuclear domains or ND10, which contain the PML protein as a critical component. This disruption is achieved through the
Araujo +37 more
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A haplotype-resolved draft genome of the European sardine (Sardina pilchardus) [PDF]
, 2019 The European sardine (Sardina pilchardus Walbaum, 1792) is culturally and economically important throughout its distribution. Monitoring studies of sardine populations report an alarming decrease in stocks due to overfishing and environmental change ...
Canario, A.V.M. +7 more
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TRIM E3 ligases interfere with early and late stages of the retroviral life cycle.
PLoS Pathogens, 2008 Members of the TRIpartite interaction Motif (TRIM) family of E3 ligases have been shown to exhibit antiviral activities. Here we report a near comprehensive screen for antiretroviral activities of 55 TRIM proteins (36 human, 19 mouse).
Pradeep D Uchil +4 more
doaj +1 more source
Evolution and expression of the duck TRIM gene repertoire
Frontiers in Immunology, 2023 Tripartite motif (TRIM) proteins are involved in development, innate immunity, and viral restriction. TRIM gene repertoires vary between species, likely due to diversification caused by selective pressures from pathogens; however, this has not been ...
Lee K. Campbell +5 more
doaj +1 more source
Hyb:A bioinformatics pipeline for the analysis of CLASH (crosslinking, ligation and sequencing of hybrids) data [PDF]
, 2013 Peer reviewedPublisher ...
Aiba +32 more
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Gene Expression Profiling of Corpus luteum Reveals Important Insights about Early Pregnancy in Domestic Sheep [PDF]
, 2020 The majority of pregnancy loss in ruminants occurs during the preimplantation stage, which is thus the most critical period determining reproductive success. Here, we performed a comparative transcriptome study by sequencing total mRNA from corpus luteum
Honkatukia, Mervi +5 more
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On the ion-mediated interaction between protein and DNA
, 2013 The mechanism allowing a protein to search of a target sequence on DNA is currently described as an intermittent process composed of 3D diffusion in bulk and 1D diffusion along the DNA molecule.
Barbi, Maria, Paillusson, Fabien
core +1 more source
TRIM-NHL proteins in development and disease
Seminars in Cell & Developmental Biology, 2015 TRIM-NHL proteins are key regulators of developmental transitions, for example promoting differentiation, while inhibiting cell growth and proliferation, in stem and progenitor cells. Abnormalities in these proteins have been also associated with human diseases, particularly affecting muscular and neuronal functions, making them potential targets for ...
Tocchini, Cristina, Ciosk, Rafal
openaire +2 more sources