Results 71 to 80 of about 5,785,343 (209)

The TRIM family protein KAP1inhibits HIV [PDF]

Cell Host & Microbe, 2011
The integration of viral cDNA into the host genome is a critical step in the life cycle of HIV-1. This step is catalyzed by integrase (IN), a viral enzyme that is positively regulated by acetylation via the cellular histone acetyl transferase (HAT) p300.
Allouch, DI PRIMIO, CRISTINA, Alpi, Terreni, Lusic, Arosio, Giacca, Cereseto   +4 more
openaire   +5 more sources

TRIM16 Overexpression in HEK293T Cells Results in Cell Line-Specific Antiviral Activity

Pathogens, 2023
Host cell restriction factors are intracellular proteins that can inhibit virus replication. Characterisation of novel host cell restriction factors can provide potential targets for host-directed therapies.
Lance R. Nigos, Nichollas E. Scott, Andrew G. Brooks, Malika Ait-Goughoulte, Sarah L. Londrigan, Patrick. C. Reading, Rubaiyea Farrukee   +6 more
doaj   +1 more source

The Echinococcus canadensis (G7) genome: A key knowledge of parasitic platyhelminth human diseases [PDF]

, 2017
Background: The parasite Echinococcus canadensis (G7) (phylum Platyhelminthes, class Cestoda) is one of the causative agents of echinococcosis. Echinococcosis is a worldwide chronic zoonosis affecting humans as well as domestic and wild mammals, which ...
A Bankevich, A Gurevich, A Lomsadze, A Lomsadze, Adolfo Fox, AM Bolger, Anna C. M. Salim, B Hendrich, B Langmead, C Bermudez-Santana, C Hahn, C Holt, C Jiang, C Trapnell, CA Alvarez Rojas, CCM Budke, D Kim, D Takai, DP McManus, DR Zerbino, E Elkayam, E Keibler, E Quevillon, F Jeanmougin, F Kiefer, F Mohn, Federico Camicia, Flávio M. Gomes Araújo, G Abrusán, G Parra, GSC Slater, Guilherme Oliveira, H Li, H Zheng, I Korf, IJ Tsai, IJ Tsai, J Eckert, JK Nono, JM Bart, JP Hewitson, Juliana Assis, K Arnold, K Matsuo, K Thivierge, K Wasik, KJ Fryxell, KK Geyer, KK Geyer, L Han, L Han, L Kamenetzky, L Kamenetzky, L Kamenetzky, L Li, LA Kelley, Laura Kamenetzky, LD Moore, Lucas L. Maldonado, M Ashburner, M Biasini, M Cucher, M Cucher, M Krzywinski, M Marín, M Nakao, M Nakao, M Nakao, M Nakao, M Nakao, M Rosenzvit, M Sajid, M Stanke, MA Cucher, Mara Rosenzvit, Marcela Cucher, MC Rosenzvit, MW Robinson, N Guex, N Macchiaroli, N Schürmann, Natalia Macchiaroli, ND Young, O Bogdanović, P Carninci, P Cingolani, P Danecek, PM Muzulin, PM Schantz, PS Craig, R Luo, R Schneider, RD Finn, RJ Klose, S Assefa, S Maillard, S Saxonov, S Yi, SF Altschul, SM Sadjjadi, TD Otto, TD Otto, TM Lowe, U Koziol, U Saarma, W Pan, Y Moriya, Y Safonova, YA Medvedeva, Z Zhao   +109 more
core   +8 more sources

Emerging Roles of TRIM Family Proteins in Gliomas Pathogenesis

Cancers, 2022
Gliomas encompass a vast category of CNS tumors affecting both adults and children. Treatment and diagnosis are often impeded due to intratumor heterogeneity and the aggressive nature of the more malignant forms. It is therefore essential to elucidate the molecular mechanisms and explore the intracellular signaling pathways underlying tumor pathology ...
Angeliki-Ioanna Giannopoulou, Charalampos Xanthopoulos, Christina Piperi, Efterpi Kostareli   +3 more
openaire   +5 more sources

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

The TRIMendous Role of TRIMs in Virus–Host Interactions

Vaccines, 2017
The innate antiviral response is integral in protecting the host against virus infection. Many proteins regulate these signaling pathways including ubiquitin enzymes.
Sarah van Tol, Adam Hage, Maria Isabel Giraldo, Preeti Bharaj, Ricardo Rajsbaum   +4 more
doaj   +1 more source

TRIM proteins in therapeutic membrane repair of muscular dystrophy. [PDF]

JAMA Neurol, 2013
Muscular dystrophy represents a major unmet medical need; only palliative treatments exist for this group of debilitating diseases. Because multiple forms of muscular dystrophy arise from compromised sarcolemmal membrane integrity, a therapeutic approach that can target this loss of membrane function could be applicable to a number of these distinct ...
Alloush J, Weisleder N.
europepmc   +4 more sources

The melanoma-associated antigen 1 (MAGEA1) protein stimulates the E3 ubiquitin-ligase activity of TRIM31 within a TRIM31-MAGEA1-NSE4 complex [PDF]

, 2015
The MAGE (Melanoma-associated antigen) protein family members are structurally related to each other by a MAGEhomology domain comprised of 2 winged helix motifs WH/A and WH/B. This family specifically evolved in placental mammals although single homologs
Alan R Lehmann, Chomez P, Christopher M Sanderson, Jan J Palecek, Karel Stejskal, Lucie Kozakova, Lucie Vondrova, Panagoula Charalabous, Peter Kolesar, Shantha Kumara HM, Stjepan Uldrijan, Zbynek Zdrahal   +11 more
core   +3 more sources

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Coiled-coil-domain-mediated TRIM E3 protein condensation modulates enzymatic activity and functional specificity

Cell Reports
Summary: Tripartite motif (TRIM) proteins are E3 ligases with modular structures involved in diverse cellular functions. Whether biomolecular condensation broadly regulates TRIM proteins remains unclear.
Qi Chen, Peiguo Yang
doaj   +1 more source