Results 81 to 90 of about 5,785,343 (209)
Frontiers in Cell and Developmental Biology, 2022 “Trim-Away” technology enables rapid degradation of endogenous proteins without prior modification of protein-coding genes or mRNAs through delivery of antibodies that target proteins of interest.
Rina Kunishige +6 more
doaj +1 more source
The novel E3 ligase of PPAR?? TRIM25 regulates adipocyte differentiation [PDF]
, 2018 Department of Biological SciencesPeroxisome proliferator-activated receptor ?? (PPAR??) is a ligand-dependent transcription factor which regulates glucose homeostasis and adipocyte differentiation.
Lee, Jae Min
core
Frontiers in Molecular Neuroscience, 2023 The tripartite motif (TRIM) protein family members have been implicated in a multitude of physiologies and pathologies in different tissues. With diverse functions in cellular processes including regulation of signaling pathways, protein degradation, and
Jane Dudley-Fraser, Katrin Rittinger
semanticscholar +1 more source
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Insights into the protein domains of C-VI TRIM subfamily in viral infection
Frontiers in Cellular and Infection MicrobiologyTripartite motif (TRIM) proteins, defined by their conserved RBCC domain architecture, play key roles in various cellular processes and virus-host interactions.
Bbumba Patrick +5 more
doaj +1 more source
The Discrete Nonlinear Schr\"odinger equation - 20 Years on
, 2002 We review work on the Discrete Nonlinear Schr\"odinger (DNLS) equation over the last two decades.Comment: 24 pages, 1 figure, Proceedings of the conference on "Localization and Energy Transfer in Nonlinear Systems", June 17-21, 2002, San Lorenzo de ...
Eilbeck, J. Chris, Johansson, Magnus
core +3 more sources
Exploring potential germline associated roles of the TRIM-NHL protein NHL-2 through RNAi screening [PDF]
, 2017 TRIM-NHL proteins are highly conserved regulators of developmental pathways in vertebrates and invertebrates. The TRIM-NHL family member NHL-2 in Caenorhabditis elegans functions as a miRNA cofactor to regulate developmental timing.
Anderson, J.W. +3 more
core +1 more source
PML protein isoforms and the RBCC/TRIM motif [PDF]
Oncogene, 2001 PML is a component of a multiprotein complex, termed nuclear bodies, and the PML protein was originally discovered in patients suffering from acute promyelocytic leukaemia (APL). APL is associated with a reciprocal chromosomal translocation of chromosomes 15 and 17, which results in a fusion protein comprising PML and the retinoic acid receptor alpha ...
K, Jensen, C, Shiels, P S, Freemont
openaire +2 more sources
FEBS Letters, EarlyView.Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source