Results 11 to 20 of about 12,013 (243)

Interest of hair tests to discriminate a tail end of a doping regimen from a possible contamination in case of challenging an anti-doping rule violation. V. Case reports involving trimetazidine, a drug where the concentration after a single 20 mg dose has been established. [PDF]

Drug Test Anal
From ingestion to hair incorporation Abstract The identification of trimetazidine, a medicine used for treating stable angina pectoris and for preventing angina attacks, has been recently observed in doping cases involving high profile athletes from various countries over the world.
Kintz P, Ameline A, Gheddar L.
europepmc   +2 more sources

Trimetazidine Alleviates Postresuscitation Myocardial Dysfunction and Improves 96‐Hour Survival in a Ventricular Fibrillation Rat Model

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022
Background Myocardial dysfunction is a critical cause of post‐cardiac arrest hemodynamic instability and circulatory failure that may lead to early mortality after resuscitation.
Jingru Li, Yuantong Qi, Jianjie Wang, Chenxi Dai, Bihua Chen, Yongqin Li   +5 more
doaj   +2 more sources

Trimetazidine attenuates dexamethasone-induced muscle atrophy via inhibiting NLRP3/GSDMD pathway-mediated pyroptosis

Cell Death Discovery, 2021
Skeletal muscle atrophy is one of the major side effects of high dose or sustained usage of glucocorticoids. Pyroptosis is a novel form of pro-inflammatory programmed cell death that may contribute to skeletal muscle injury.
Li Wang, Xin-Feng Jiao, Cheng Wu, Xiao-Qing Li, Hui-Xian Sun, Xi-Yu Shen, Kang-Zhen Zhang, Can Zhao, Li Liu, Man Wang, Yun-Ling Bu, Jia-Wen Li, Fan Xu, Chen-Lu Chang, Xiang Lu, Wei Gao   +15 more
doaj   +2 more sources

The effects of trimetazidine on lipopolysaccharide-induced oxidative stress in mice [PDF]

, 2011
The effects of trimetazidine, a novel anti-ischemic agent, on the development of oxidative stress induced in mice with lipopolysaccharide endotoxin were investigated.
Omar M. E. Abdel‐Salam, Nadia A. Mohammed, Amany A. Sleem   +2 more
openalex   +4 more sources

Trimetazidine: Activating AMPK Signal to Ameliorate Coronary Microcirculation Dysfunction after Myocardial Infarction

Frontiers in Bioscience-Landmark
Background: Myocardial ischemia-reperfusion (I/R) injury and coronary microcirculation dysfunction (CMD) are observed in patients with myocardial infarction after vascular recanalization.
Xiaolong Qu, Pan Yang, Li Jiao, Yuehui Yin   +3 more
doaj   +2 more sources

Effect of remote ischemic preconditioning, nicorandil, and trimetazidine in contrast-induced nephropathy: a network meta-analysis of randomized controlled trials [PDF]

Renal Failure
Introduction Contrast-induced nephropathy (CIN) is a potential complication associated with the administration of intravenous contrast agents. The objective of this study was to evaluate the effectiveness of remote ischemic preconditioning (RIPC) and two
Hanchao Gao, Weilong Li, Chuanchuan Sun, Shiping Zhu, Fanna Liu, Xinhai Zhao, Shaodong Luan, Shengyun Sun, Yeye Yu   +8 more
doaj   +2 more sources

The effect of trimetazidine on cardiac haemodynamics and mitochondrial function in wild‐type transthyretin amyloidosis

ESC Heart Failure
Aims Wild‐type transthyretin cardiac amyloidosis (ATTRwt) is a cardiomyopathy causing myocardial hypoperfusion and impaired cardiac mitochondrial function. Trimetazidine is an antianginal agent used in patients with stable angina pectoris, which improves
Bertil Thyrsted Ladefoged, Anders Lehmann Dahl Pedersen, Anne Mette Dybro, Tor Skibsted Clemmensen, Julian Gillmore, Steen Hvitfeldt Poulsen   +5 more
doaj   +2 more sources

Metabolic study of trimetazidine using ultra-high performance liquid chromatography-tandem mass spectrometry [PDF]

Brazilian Journal of Pharmaceutical Sciences, 2023
In the present study, the application of ultra-high performance liquid chromatography-tandem mass spectrometry allowed us to study of known-as well as hitherto unknown-trimetazidine (TMZ) metabolites in human urine and to propose their renal excretion ...
Kamila Chomaničová, Élida Alechaga Silva, Rosa Ventura Alemany   +2 more
doaj   +1 more source

Combined β-sitosterol and trimetazidine mitigate potassium dichromate-induced cardiotoxicity in rats through the interplay between NF-κB/AMPK/mTOR/TLR4 and HO-1/NADPH signaling pathways

Environmental science and pollution research international, 2023
Hexavalent chromium salt, like potassium dichromate (PD), is chromium’s most precarious valence state in industrial wastes. Recently, there has been increasing interest in β-sitosterol (BSS), a bioactive phytosterol, as a dietary supplement.
Ehab A. M. El-Shoura, M. A. Salem, Yasmine H. Ahmed, Lamiaa Khalaf Ahmed, Dalia K. Zaafar   +4 more
semanticscholar   +1 more source

Trimetazidine in heart failure with preserved ejection fraction: a randomized controlled cross‐over trial

ESC Heart Failure, 2023
Impaired myocardial energy homeostasis plays an import role in the pathophysiology of heart failure with preserved ejection fraction (HFpEF). Left ventricular relaxation has a high energy demand, and left ventricular diastolic dysfunction has been ...
A. A. Bovenkamp, K. J. Geurkink, Frank T Oosterveer, Frances S. Man, Wouter E.M. Kok, Patrick N.A. Bronzwaer, Cor P. Allaart, A. Nederveen, Albert C. Rossum, A. Bakermans, M. Louis Handoko   +10 more
semanticscholar   +1 more source