Effects of trimetazidine on heart failure with reduced ejection fraction and associated clinical outcomes: a systematic review and meta-analysis [PDF]
Open HeartBackground Despite maximal treatment, heart failure (HF) remains a major clinical challenge. Besides neurohormonal overactivation, myocardial energy homoeostasis is also impaired in HF.
M Louis Handoko +5 more
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Trimetazidine in Heart Failure [PDF]
Frontiers in Pharmacology, 2021 Heart failure is a systemic syndrome caused by multiple pathological factors. Current treatments do not have satisfactory outcomes. Several basic studies have revealed the protective effect of trimetazidine on the heart, not only by metabolism modulation but also by relieving myocardial apoptosis, fibrosis, autophagy, and inflammation. Clinical studies
Hongyang Shu +8 more
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Trimetazidine Attenuates Heart Failure by Improving Myocardial Metabolism via AMPK
Frontiers in Pharmacology, 2021 Energic deficiency of cardiomyocytes is a dominant cause of heart failure. An antianginal agent, trimetazidine improves the myocardial energetic supply.
Hongyang Shu +13 more
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Cell Death Discovery, 2021 Skeletal muscle atrophy is one of the major side effects of high dose or sustained usage of glucocorticoids. Pyroptosis is a novel form of pro-inflammatory programmed cell death that may contribute to skeletal muscle injury.
Li Wang +15 more
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Trimetazidine enhances myocardial angiogenesis in pressure overload-induced cardiac hypertrophy mice through directly activating Akt and promoting the binding of HSF1 to VEGF-A promoter [PDF]
Acta Pharmacologica Sinica, 2022 Latest clinical research shows that trimetazidine therapy during the perioperative period relieves endothelial dysfunction in patients with unstable angina induced by percutaneous coronary intervention. In this study we investigated the effects of TMZ on
Hongyang Shu +6 more
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Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022 Background Myocardial dysfunction is a critical cause of post‐cardiac arrest hemodynamic instability and circulatory failure that may lead to early mortality after resuscitation.
Jingru Li +5 more
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Comprehensive metabolite profiling of trimetazidine in camels using high-Resolution accurate mass Spectrometry: implications for doping control [PDF]
Rapid Communications in Mass Spectrometry, 2023 RATIONALE Trimetazidine and its metabolites are prohibited substances in sports. With a growing number of adverse findings in human athletes, it is crucial to develop doping control strategies that include screening for trimetazidine in animal sports ...
Jahfar Nalakath +8 more
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[Retracted] Observation of Curative Effect of Trimetazidine Combined with Metoprolol in Elderly Patients with Coronary Heart Disease Complicated with Heart Failure and the Effect of Myocardial Remodeling by Integrated Traditional Chinese and Western Medicine [PDF]
BioMed Research International, 2022 Diabetic retinopathy (DR) is the most common complication of diabetes and is often characterized by damage to retinal vascular microcirculation, resulting in retinal exudation, hemorrhage, fibrosis, and neovascularization.
Yingyi Lu +4 more
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ESC Heart FailureAims Wild‐type transthyretin cardiac amyloidosis (ATTRwt) is a cardiomyopathy causing myocardial hypoperfusion and impaired cardiac mitochondrial function. Trimetazidine is an antianginal agent used in patients with stable angina pectoris, which improves
Bertil Thyrsted Ladefoged +5 more
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