Results 31 to 40 of about 8,387 (243)

Trimetazidine and exercise provide comparable improvements to high fat diet-induced muscle dysfunction through enhancement of mitochondrial quality control

Scientific Reports, 2021
Obesity induces skeletal muscle dysfunction. The pathogenesis of which appears to substantially involve mitochondrial dysfunction, arising from impaired quality control. Exercise is a major therapeutic strategy against muscle dysfunction.
Wenliang Zhang, Baiyang You, Dake Qi, Ling Qiu, Jeffrey W. Ripley-Gonzalez, Fan Zheng, Siqian Fu, Cui Li, Yaoshan Dun, Suixin Liu   +9 more
doaj   +1 more source

Trimetazidine for stable angina [PDF]

Cochrane Database of Systematic Reviews, 2005
Patients with stable angina not controlled by monotherapy with nitrates, beta blockers, or calcium channel blockers are often treated with combinations of these drugs. There may be adverse effects from, or contraindications to, the use of combinations.
A, Ciapponi, R, Pizarro, J, Harrison
openaire   +2 more sources

The effectiveness of cytocardioprotection of patients with the moderately expressed post infarct dysfunction of left heart ventricle: the results of the randomization research of trimetazidine and athenolole

Бюллетень сибирской медицины, 2002
With the purpose of research of clinical efficiency of trimetazidine and atenolol and their influence on morfofunctional parameteres of left ventricle 36 men who have transferred a myocardial infarction are inspected.
V. V. Kalyuzhin, M. A. Solovtsov, D. U. Kamaev   +2 more
doaj   +1 more source

ACPTI study: Being positive in a negative situation is not naivety – Trimetazidine still has role in symptomatic CAD patients

Indian Heart Journal, 2021
Results: of the efficAcy and safety of Trimetazidine in patients with angina pectoris having been treated by Percutaneous Coronary Intervention (ATPCI) study showed no significant difference in the incidence of primary endpoint events between ...
Jamshed Dalal, Aditya Kapoor
doaj   +1 more source

Trimetazidine Ameliorates Myocardial Metabolic Remodeling in Isoproterenol-Induced Rats Through Regulating Ketone Body Metabolism via Activating AMPK and PPAR α

Frontiers in Pharmacology, 2020
BackgroundMetabolic remodeling plays a vital role in the development of heart failure. The trimetazidine can optimize fatty acid and glucose oxidation via inhibition of long-chain 3-ketoacyl CoA thiolase in the heart.
Huihui Li, Huihui Li, Zhi Ma, Yajun Zhai, Chao Lv, Peng Yuan, Feng Zhu, Liping Wei, Qi Li, Xin Qi   +9 more
doaj   +1 more source

Trimetazidine in heart failure with preserved ejection fraction: a randomized controlled cross‐over trial

ESC Heart Failure, 2023
Impaired myocardial energy homeostasis plays an import role in the pathophysiology of heart failure with preserved ejection fraction (HFpEF). Left ventricular relaxation has a high energy demand, and left ventricular diastolic dysfunction has been ...
A. A. van de Bovenkamp, K. J. Geurkink, Frank T. P. Oosterveer, Frances S. de Man, Wouter E. M. Kok, P. Bronzwaer, C. Allaart, A. Nederveen, A. V. van Rossum, A. Bakermans, M. Handoko   +10 more
semanticscholar   +1 more source

Combined β-sitosterol and trimetazidine mitigate potassium dichromate-induced cardiotoxicity in rats through the interplay between NF-κB/AMPK/mTOR/TLR4 and HO-1/NADPH signaling pathways

Environmental science and pollution research international, 2023
Hexavalent chromium salt, like potassium dichromate (PD), is chromium’s most precarious valence state in industrial wastes. Recently, there has been increasing interest in β-sitosterol (BSS), a bioactive phytosterol, as a dietary supplement.
Ehab A. M. El-Shoura, M. A. Salem, Yasmine H. Ahmed, Lamiaa Khalaf Ahmed, Dalia K. Zaafar   +4 more
semanticscholar   +1 more source

Metabolic regulation to treat bipolar depression: mechanisms and targeting by trimetazidine

Molecular Psychiatry, 2023
Bipolar disorder’s core feature is the pathological disturbances in mood, often accompanied by disrupted thinking and behavior. Its complex and heterogeneous etiology implies that a range of inherited and environmental factors are involved.
Sourav Khanra, P. Reddy, A. Giménez-Palomo, C. H. J. Park, B. Panizzutti, Madeleine McCallum, S. Arumugham, S. Umesh, M. Debnath, B. Das, G. Venkatasubramanian, Melanie M. Ashton, A. Turner, O. Dean, K. Walder, E. Vieta, L. Yatham, I. Pacchiarotti, Y. J. Janardhan Reddy, N. Goyal, M. Kesavan, L. Colomer, Michael Berk, J. H. Kim   +23 more
semanticscholar   +1 more source

The Potential Role of Baseline FT3/FT4 Ratio as a Prognostic Biomarker for Patients With Ischemic Non-Obstructive Coronary Artery Disease. [PDF]

Clin Cardiol
A low FT3/FT4 ratio indicates a significant increase in the risk of major adverse cardiovascular events in INOCA patients, or a novel biomarker for prognosis. ABSTRACT Background Ischemia with non‐obstructive coronary artery disease (INOCA) is associated with an increased risk of major adverse cardiovascular events (MACE).
Wu F, Zheng X, Hong L, Wu Q, Yang R, Xie X, Ren W, Cai Z, Xiao Y, Zhou Y.   +9 more
europepmc   +2 more sources

Effectiveness of Trimetazidine, a Cytoprotective Agent in Ischemic Heart Disease

, 2021
Objectives: Metabolic agents such as trimetazidine offer a benefits role of cytoprotection in ischemic heart disease (IHD) through an inhibition of cardiac fatty acid oxidation and improving myocardial glucose utilization.
Harinder Jot Singh, Navpreet Kaur, Sami Manzoor, Sanjay Nayyar, Sharanjit Kaur   +4 more
core   +1 more source