Results 11 to 20 of about 8,387 (243)

Efficacy of Trimetazidine Dihydrochloride for Relieving Chronic Tinnitus: A Randomized Double-Blind Study [PDF]

open access: yesClinical and Experimental Otorhinolaryngology, 2016
Objectives. To evaluate the efficacy of trimetazidine dihydrochloride as a treatment for chronic tinnitus. Methods. A total of 97 chronic tinnitus patients were evaluated in this randomized, prospective, double-blind, placebo-controlled trial.
Tolgar Lütfi Kumral   +6 more
doaj   +2 more sources

Trimetazidine: Activating AMPK Signal to Ameliorate Coronary Microcirculation Dysfunction after Myocardial Infarction

open access: yesFrontiers in Bioscience-Landmark
Background: Myocardial ischemia-reperfusion (I/R) injury and coronary microcirculation dysfunction (CMD) are observed in patients with myocardial infarction after vascular recanalization.
Xiaolong Qu   +3 more
doaj   +2 more sources

Trimetazidine protects against smoking-induced left ventricular remodeling via attenuating oxidative stress, apoptosis, and inflammation. [PDF]

open access: yesPLoS ONE, 2012
Trimetazidine, a piperazine derivative used as an anti-anginal agent, improves myocardial glucose utilization through inhibition of fatty acid metabolism.
Xiang Zhou   +3 more
doaj   +2 more sources

Metabolic study of trimetazidine using ultra-high performance liquid chromatography-tandem mass spectrometry [PDF]

open access: yesBrazilian Journal of Pharmaceutical Sciences, 2023
In the present study, the application of ultra-high performance liquid chromatography-tandem mass spectrometry allowed us to study of known-as well as hitherto unknown-trimetazidine (TMZ) metabolites in human urine and to propose their renal excretion ...
Kamila Chomaničová   +2 more
doaj   +2 more sources

Beneficial effects of trimetazidine on expression of serotonin and serotonin transporter in rats with myocardial infarction and depression

open access: yesNeuropsychiatric Disease and Treatment, 2018
Meiyan Liu,1,* Wanlin Wei,2,* Christopher R Stone,3 Lijun Zhang,1 Guoxiang Tian,4 Jessie N Ding3 1Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, People’s Republic of China; 2Department of Cardiology, PLA ...
Liu MY   +5 more
doaj   +1 more source

Cardioprotective Effect of Trimetazidine in Cardiac Contusion: Experimental Study [PDF]

open access: yesОбщая реаниматология, 2008
Objective: to study the efficiency of pre-administration of trimetazidine in experimental cardiac contusion in order to lower the degree of posttraumatic myocardial dysfunction.
O. V. Korpacheva, V. T. Dolgikh
doaj   +2 more sources

Role of Trimetazidine in Ameliorating Endothelial Dysfunction: A Review

open access: yesPharmaceuticals
Endothelial dysfunction is a hallmark of cardiovascular diseases, contributing to impaired vasodilation, altered hemodynamics, and atherosclerosis progression. Trimetazidine, traditionally used for angina pectoris, exhibits diverse therapeutic effects on
Y. Kamisah, H. H. Che Hassan
semanticscholar   +2 more sources

Effect of trimetazidine on left ventricular functions and cardiac biomarkers in diabetic patients with left ventricular diastolic dysfunction: a randomized controlled trial

open access: yesScientific Reports
We investigated the impact of trimetazidine treatment on left ventricular (LV) functions and cardiac biomarkers in diabetic patients with diastolic dysfunction as an early stage of diabetic cardiomyopathy.
Heba Serag   +5 more
doaj   +2 more sources

Effectiveness of the original trimetazidine MR in patients with stable coronary heart disease and angina attacks resistant to trimetazidine generics (ETALON study) [PDF]

open access: yesКардиоваскулярная терапия и профилактика, 2011
Aim. To assess the clinical benefits of the original trimetazidine medication (Preductal® MR) in patients with stable coronary heart disease and angina attacks resistant to trimetazidine generics. Material and methods.
A. V. Fendrikova, V. V. Skibitskyi
doaj   +2 more sources

Comparative study: trimetazidine versus olanzapine on cognitive dysfunction and behavioral changes in ketamine-induced psychosis model in mice

open access: yesThe Egyptian Journal of Neurology, Psychiatry and Neurosurgery
Background Mitochondrial dysfunction and oxidative stress may contribute to schizophrenia. Negative symptoms and cognitive dysfunction in individuals with schizophrenia are resistant to anti-psychotic medications, but physical exercise is an effective ...
Yosra Magdy   +4 more
doaj   +2 more sources

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