Results 21 to 30 of about 8,387 (243)

Trimetazidine effects on intracellular Са2+ ion concentration in HL-60 human promyelocytes [PDF]

Кардиоваскулярная терапия и профилактика, 2008
Aim. To investigate the effects of an anti-ischemic medication trimetazidine on Са2+ ion metabolism in human leukocyte and monocyte precursors – HL-60 promyelocytes.Material and methods. HL-60 cells were cultivated in vitro. Changes in intracellular free
E. I. Astashkin, M. G. Glezer, S. V. Grachev   +2 more
doaj   +1 more source

Effects of trimetazidine on heart failure with reduced ejection fraction and associated clinical outcomes: a systematic review and meta-analysis

Open Heart
Background Despite maximal treatment, heart failure (HF) remains a major clinical challenge. Besides neurohormonal overactivation, myocardial energy homoeostasis is also impaired in HF.
M Louis Handoko, Soufiane Nassiri, Arno A Van de Bovenkamp, Sharon Remmelzwaal, Olimpia Sorea, Frances de Man   +5 more
doaj   +2 more sources

Trimetazidine attenuates dexamethasone-induced muscle atrophy via inhibiting NLRP3/GSDMD pathway-mediated pyroptosis

Cell Death Discovery, 2021
Skeletal muscle atrophy is one of the major side effects of high dose or sustained usage of glucocorticoids. Pyroptosis is a novel form of pro-inflammatory programmed cell death that may contribute to skeletal muscle injury.
Li Wang, Xin-Feng Jiao, Cheng Wu, Xiao-Qing Li, Hui-Xian Sun, Xi-Yu Shen, Kang-Zhen Zhang, Can Zhao, Li Liu, Man Wang, Yun-Ling Bu, Jia-Wen Li, Fan Xu, Chen-Lu Chang, Xiang Lu, Wei Gao   +15 more
doaj   +2 more sources

Design, Synthesis and Molecular Docking Studies of Some Novel Hydrazone Derivatives Based on Trimetazidine as Selective and Potent AChE Inhibitors. [PDF]

Drug Dev Res
ABSTRACT Alzheimer's disease (AD) is a progressive neurodegenerative disease, and cholinergic dysfunction is considered one of the fundamental pathological factors of this disease. Guided by the clinically used acetylcholinesterase (AChE) inhibitor donepezil, we explored trimetazidine dihydrochloride as an accessible starting scaffold to generate ...
Doğan MO, Özkan BNS, Karaduman AB, Karakuş S, Özkay Y, Kaplancıklı ZA, Tok F.   +6 more
europepmc   +2 more sources

The effect of trimetazidine on cardiac haemodynamics and mitochondrial function in wild‐type transthyretin amyloidosis

ESC Heart Failure
Wild‐type transthyretin cardiac amyloidosis (ATTRwt) is a cardiomyopathy causing myocardial hypoperfusion and impaired cardiac mitochondrial function.
B. Ladefoged, A. D. Pedersen, A. Dybro, T. Clemmensen, J. Gillmore, S. H. Poulsen   +5 more
semanticscholar   +2 more sources

Potential Mechanisms of Trimetazidine and Coenzyme Q10 Against Antipsychotic-Induced Myocarditis: A Network Pharmacology, Molecular Docking, and Molecular Dynamics Simulation Study. [PDF]

CNS Neurosci Ther
In this study, we explored the mechanisms for the therapeutic effects of TMZ and CoQ10 on myocarditis using network pharmacology, molecular docking, and molecular dynamics simulations. Our findings identified core targets of TMZ and CoQ10 treatment of myocarditis; the five core targets included EGFR, MMP9, PPARG, AKT1, and CASP3.
Chen X, Zhuo D, Zou J, Song H, Yao K, Tian H, Zhuo C.   +6 more
europepmc   +2 more sources

Trimetazidine use in Parkinson's disease: Is it a resolved problem? [PDF]

, 2021
Trimetazidine, an antianginal drug, can worsen the symptoms of movement disorders, therefore, the European Medicines Agency (EMA) recommended avoiding the use of this drug in Parkinson's disease (PD).
Janszky, József Vladimír, Pintér, Dávid, Kovács, Norbert, Oberfrank, Ferenc, Ajtay, András, Bereczki, Dániel   +5 more
core   +1 more source

Repurposing of Trimetazidine for amyotrophic lateral sclerosis: A study in SOD1G93A mice [PDF]

, 2022
Background and Purpose: Amyotrophic lateral sclerosis (ALS), a neurodegenerative disease characterized by the degeneration of upper and lower motor neurons, progressive wasting and paralysis of voluntary muscles and is currently incurable.
Urbani A., Pieroni L.
core   +2 more sources

Trimetazidine has Promising Preventive Effects on Experimental Chronic Pancreatitis Rat Model

The Turkish Journal of Gastroenterology, 2022
Background: It was aimed to evaluate the preventive efficacy of trimetazidine in an experimental chronic pancreatitis rat model. Methods: Chronic pancreatitis model was accomplished with caerulein and alcohol administration.
Mustafa Kaplan, Arif Karakaya, Alpaslan Tanoğlu, Muhammet Yıldırım, Yeşim Önal Taştan, Zafer Çırak, Zafer Küçükodacı   +6 more
doaj   +1 more source

Effectiveness and Tolerability of Trimetazidine 80 mg Once Daily in Patients with Chronic Coronary Syndrome in Brazil: The V-GOOD Observational Study. [PDF]

Cardiol Ther
The V-GOOD study evaluated the effectiveness of trimetazidine modified-release (MR) 80 mg once daily (OD) in patients with chronic coronary syndrome (CCS) who remained symptomatic despite antianginal therapies in routine clinical practice.
Gowdak LHW, Dourado PMM, Précoma DB, de Oliviera Lopes Dusilek C, da Silva FM, Yugar-Toledo JC, Pena FM, de Almeida Gomes DA, do Espírito Santo Cestário E, Guimarães OR, Filho CRH, de Almeida CF, de Souza Brito F, Martins GF, Ferreira VRR, Flores MC, da Silva ML, V-GOOD Investigators.   +17 more
europepmc   +2 more sources