Results 41 to 50 of about 8,387 (243)

Effects of Trimetazidine on Right Ventricular Function and Ventricular Remodeling in Patients with Pulmonary Artery Hypertension: A Randomised Controlled Trial

Journal of Clinical Medicine, 2023
Background: Pulmonary artery hypertension (PAH) is a chronic and progressive disease. Although current therapy has improved the disease prognosis, PAH has a poor survival rate. The key feature leading to disease progression and death is right ventricular
H. Verdejo, Adolfo Rojas, C. López-Crisosto, Fernando Baraona, L. Gabrielli, Vinicius Maracaja-Coutinho, M. Chiong, S. Lavandero, P. Castro   +8 more
semanticscholar   +1 more source

Triple antianginal combinations in the treatment of elderly and senile patients with stable angina [PDF]

Терапевтический архив, 2016
Aim. To compare the efficiency and safety of antianginal therapy (AAT) using a combination of bisoprolol, ivabradine, and trimetazidine or ranolazine in elderly and senile patients with stable angina. Subjects and methods. The study enrolled 107 patients
S G Kanorskii, N V Smolenskaya
doaj   +1 more source

AN EXPERIENCE OF TRIMETAZIDINE USAGE IN COMORBIDITY [PDF]

, 2018
Aim. To assess the dynamics of heart rate variability (HRV) during the therapy with trimetazidine instable angina patients comorbid with diabetes. Material and methods.
G. M. Panyushkina, T. M. Chernykh, I. V. Kochetkova   +2 more
core   +1 more source

The efficacy of trimetazidine in non-ischemic heart failure patients: a meta-analysis of randomized controlled trials

Reviews in Cardiovascular Medicine, 2021
Trimetazidine has been reported to benefit patients with heart failure (HF) and angina. The impact of trimetazidine on non-ischemic HF remains unclear.
Chengchen Zhao, Chunna Jin, Xiaopeng He, Meixiang Xiang   +3 more
doaj   +1 more source

Trimetazidine and Cardioprotection

Angiology, 2014
Trimetazidine (TMZ) is a metabolic agent used in cardiology for more than 40 years. Several studies assessed the cardioprotective effects of TMZ in patients with chronic coronary heart disease (CHD) as well as in patients with heart failure (HF). In light of the inclusion of TMZ in the current guidelines on the management of stable CHD, we reviewed the
Tsioufis, K., Andrikopoulos, G., Manolis, A.   +2 more
openaire   +3 more sources

Effects of Trimetazidine Pretreatment on Endothelial Dysfunction and Myocardial Injury in Unstable Angina Patients Undergoing Percutaneous Coronary Intervention

Cardiology Research and Practice, 2019
Objectives. Trimetazidine is an anti-ischemic medication licensed for the treatment of angina pectoris. However, the molecular mechanisms underlying its action remain incompletely elucidated. In this study, therefore, we examined the potential beneficial
Shuai Shao, Zhaozhao Shi, Gary Tse, Xinghua Wang, Yanping Ni, Hongmei Liu, Tong Liu, Guangping Li   +7 more
doaj   +1 more source

Metabolic intervention with trimetazidine improves intracardiac hemodynamics and reduces re-hospitalizations in patients with advanced heart failure. [PDF]

Am J Cardiovasc Dis
OBJECTIVES We tested whether management with metabolic cytoprotective and antiischemic agent trimetazidine may reduce readmissions in advanced heart failure (HF) patients through the possible improvement of left ventricular ejection fraction (LV EF) and ...
Sisakian HS, Muradyan NA, Babayan AV, Sargsyan LA, Shamyar SA, Chopikyan AS, Shahnazaryan SA.   +6 more
europepmc   +2 more sources

Use of a gene expression signature to identify trimetazidine for repurposing to treat bipolar depression

Bipolar Disorders, 2023
The aim of this study was to repurpose a drug for the treatment of bipolar depression.
C. Bortolasci, Srisaiyini Kidnapillai, B. Spolding, Trang T. T. Truong, T. Connor, Courtney Swinton, B. Panizzutti, Zoe S. J. Liu, A. Sanigorski, O. Dean, T. Crowley, M. Richardson, K. Bozaoglu, K. Vlahos, S. Cowdery, Brad Watmuff, S. Steyn, D. Wolmarans, Barend J Engelbrecht, C. Perry, Katherine D Drummond, T. Pang, S. Jamain, L. Gray, S. McGee, B. Harvey, J. H. Kim, M. Leboyer, Michael Berk, K. Walder   +29 more
semanticscholar   +1 more source

Effect of trimetazidine on myocardial salvage index in patients with acute ST segment elevation myocardial infarction undergoing primary PCI

The Egyptian Heart Journal, 2013
Introduction: Acute STEMI is the most serious presentation of CAD. Restoration of the coronary flow facilitates cardiomyocyte salvage and decreases cardiac morbidity and mortality. However, reperfusion may result in paradoxical cardiomyocyte dysfunction,
Foad Khaled, Elmahmoudy Ahmed, Bastawy Islam, Khaled Saeed   +3 more
doaj   +1 more source

An open-label Phase 2a study to assess the safety and tolerability of trimetazidine in patients with amyotrophic lateral sclerosis. [PDF]

Brain Commun
Metabolic imbalance is associated with amyotrophic lateral sclerosis progression. Impaired glucose oxidation and increased reliance on fatty acid oxidation contribute to reduced metabolic flexibility and faster disease progression in amyotrophic lateral ...
van Eijk RPA, Steyn FJ, Janse van Mantgem MR, Schmidt A, Meyjes M, Allen S, Daygon DV, Loeffler JP, Al-Chalabi A, van den Berg LH, Henderson RD, Ngo ST.   +11 more
europepmc   +2 more sources