Results 51 to 60 of about 8,387 (243)

Trimetazidine and Other Metabolic Modifiers [PDF]

European Cardiology Review, 2018
Treatment goals for people with chronic angina should focus on the relief of symptoms and improving mortality rates so the patient can feel better and live longer. The traditional haemodynamic approach to ischaemic heart disease was based on the assumption that increasing oxygen supply and decreasing oxygen demand would improve symptoms.
Marzilli, Mario, Giuseppina Capozza, Paola Francesca, Morrone, Doralisa, Huqi, Alda, Guarini, Giacinta   +4 more
openaire   +2 more sources

Trimetazidine Effect on Neutrophils count in Post IKKP [PDF]

, 2016
Background: Reperfusion strategy, either with thrombolytic or Primary Percutaneous Coronary Intervention (PPCI), is the core treatment for Acute ST-Segment Elevation Myocardial Infarct (STEMI).
Yoga Yuniadi, Yuniadi, Yoga, Haryono, Nur, Taka Mehi, Nur Haryono, Mehi, Taka   +5 more
core   +1 more source

The cystathionine γ-lyase/hydrogen sulfide pathway mediates the trimetazidine-induced protection of H9c2 cells against hypoxia/reoxygenation-induced apoptosis and oxidative stress

Anatolian Journal of Cardiology, 2019
Objective: Trimetazidine is a piperazine-derived metabolic agent. It exerts cardioprotective effects against myocardial ischemia/reperfusion (I/R) injury.
Wenqing Zheng, Chao Liu
doaj   +1 more source

The inhibitory effect of trimetazidine on detrusor contractility – a potential repositioning of trimetazidine for the treatment of overactive bladder

Journal of Pharmacy and Pharmacology, 2022
Abstract Objectives This study aimed to identify the effect of trimetazidine (TMZ), an antianginal drug, on detrusor smooth muscle (DSM) contractility and its possible mechanisms of action. Methods We performed in-vitro contractility ...
Seckin Engin, Yesim Kaya Yasar, Elif Nur Barut, Damla Getboga, Yasemin Erac, Sena F Sezen   +5 more
openaire   +2 more sources

Comprehensive metabolite profiling of trimetazidine in camels using high-resolution accurate mass spectrometry: Implications for doping control.

Rapid Communications in Mass Spectrometry, 2023
RATIONALE Trimetazidine and its metabolites are prohibited substances in sports. With a growing number of adverse findings in human athletes, it is crucial to develop doping control strategies that include screening for trimetazidine in animal sports ...
J. Nalakath, Rasik Pt, A. Kadry, Ansar Babu Palathinkal, O. K. Praseen, Ibrahimwaseem Nelliyott, Christiana Hebel, N. Selvapalam, E. Nagarajan   +8 more
semanticscholar   +1 more source

Trimetazidine Induces Parkinsonism, Gait Disorders and Tremor

, 2007
Objective: To study the adverse effects of trimetazidine on motor functions. Design: A retrospective study was carried out using electronic records to identify all patients seen between January 1990 and August 2003.
José-Félix Martí Massó, Itxaso Martí, Nieves Carrera, Juan-José Poza, Adolfo López de Munain   +4 more
core   +1 more source

Comparison of Cardioprotective Effects of Dapagliflozin and Trimetazidine in the Model of Doxorubicin-Cyclophosphamide Cardiotoxicity

Innovative Medicine of Kuban, 2023
Background: Data published by task groups of the Ministry of Health of the Russian Federation, the European Society of Cardiology, and other medical associations and institutions show that chemotherapy-induced cardiomyopathy is still a challenging issue ...
A. Avagimyan, A. I. Trofimenko, M. Sheibani, L. Kakturskiy, O. I. Urazova, G. A. Navasardyan, Z. Jndoyan, N. V. Sulashvili, L. I. Gabunia, N. S. Gorgaslidze, F. Khamidova, L. A. Martemyanova, N. V. Pogosova, N. Sarrafzadegan   +13 more
semanticscholar   +1 more source

Determination of trimetazidine in urine by capillary electrophoresis with amperometric detection

Chemical Monthly, 2023
In this contribution, nonaqueous capillary electrophoresis with end-column amperometric detection using a platinum ultramicroelectrode is presented along with several extraction procedures, both liquid–liquid extraction (LLE) and solid-phase extraction ...
Martin Baroch, H. Dejmková, F. Matysik
semanticscholar   +1 more source

Trimetazidine Affects Mitochondrial Calcium Uniporter Expression to Restore Ischemic Heart Function via Reactive Oxygen Species/NFκB Pathway Inhibition

Journal of Cardiovascular Pharmacology, 2023
Supplemental Digital Content is Available in the Text. Abstract: Studies have demonstrated the roles of trimetazidine beyond being an antianginal agent in ischemic heart disease (IHD) treatment associated with mechanisms of calcium regulation. Our recent
Zilong Xiao, Li-Chun Guan, Hui Shi, Yong Yu, Ziqing Yu, Sheng-Mei Qin, Yan-Gang Su, Rui-Zhen Chen, Minghui Li, Junbo Ge   +9 more
semanticscholar   +1 more source

Metabolic remodelling in anthracycline cardiotoxicity: mechanisms and therapeutic insights

British Journal of Pharmacology, EarlyView.
Cardiac metabolic remodelling in anthracycline‐induced cardiomyopathy and metabolically oriented cardioprotective strategies. Schematic representation of substrate utilization, mitochondrial bioenergetic function and metabolic flexibility in the healthy heart, in anthracycline‐induced cardiomyopathy and under potential cardioprotective interventions ...
Giulia Guerra, Francesco Niro, Marco Mergiotti, Giovanni Gavatorta, Emilio Hirsch, Alessandra Ghigo   +5 more
wiley   +1 more source