Results 21 to 30 of about 12,013 (243)

Trimetazidine protects against smoking-induced left ventricular remodeling via attenuating oxidative stress, apoptosis, and inflammation. [PDF]

PLoS ONE, 2012
Trimetazidine, a piperazine derivative used as an anti-anginal agent, improves myocardial glucose utilization through inhibition of fatty acid metabolism.
Xiang Zhou, Chao Li, Weiting Xu, Jianchang Chen   +3 more
doaj   +1 more source

Metabolic regulation to treat bipolar depression: mechanisms and targeting by trimetazidine

Molecular Psychiatry, 2023
Bipolar disorder’s core feature is the pathological disturbances in mood, often accompanied by disrupted thinking and behavior. Its complex and heterogeneous etiology implies that a range of inherited and environmental factors are involved.
Sourav Khanra, P. Reddy, Anna Giménez-Palomo, C. H. J. Park, B. Panizzutti, Madeleine McCallum, S. Arumugham, S. Umesh, M. Debnath, B. Das, G. Venkatasubramanian, M. Ashton, A. Turner, O. Dean, K. Walder, E. Vieta, L. Yatham, I. Pacchiarotti, Y. Reddy, N. Goyal, M. Kesavan, L. Colomer, Michael Berk, Jee Hyun Kim   +23 more
semanticscholar   +1 more source

Efficacy of Trimetazidine Dihydrochloride for Relieving Chronic Tinnitus: A Randomized Double-Blind Study [PDF]

Clinical and Experimental Otorhinolaryngology, 2016
Objectives. To evaluate the efficacy of trimetazidine dihydrochloride as a treatment for chronic tinnitus. Methods. A total of 97 chronic tinnitus patients were evaluated in this randomized, prospective, double-blind, placebo-controlled trial.
Tolgar Lütfi Kumral, Güven Yıldırım, Güler Berkiten, Ziya Saltürk, Enes Ataç, Yavuz Atar, Yavuz Uyar   +6 more
doaj   +1 more source

Effects of Trimetazidine on Right Ventricular Function and Ventricular Remodeling in Patients with Pulmonary Artery Hypertension: A Randomised Controlled Trial

Journal of Clinical Medicine, 2023
Background: Pulmonary artery hypertension (PAH) is a chronic and progressive disease. Although current therapy has improved the disease prognosis, PAH has a poor survival rate. The key feature leading to disease progression and death is right ventricular
H. Verdejo, Adolfo Rojas, Camila López-Crisosto, Fernando Baraona, L. Gabrielli, V. Maracaja-Coutinho, M. Chiong, S. Lavandero, P. Castro   +8 more
semanticscholar   +1 more source

Comprehensive metabolite profiling of trimetazidine in camels using high-resolution accurate mass spectrometry: Implications for doping control.

Rapid Communications in Mass Spectrometry, 2023
RATIONALE Trimetazidine and its metabolites are prohibited substances in sports. With a growing number of adverse findings in human athletes, it is crucial to develop doping control strategies that include screening for trimetazidine in animal sports ...
J. Nalakath, Rasik Pt, Ahmed Kadry, Ansar Babu Palathinkal, O. K. Praseen, Ibrahimwaseem Nelliyott, Christiana Hebel, N. Selvapalam, E. Nagarajan   +8 more
semanticscholar   +1 more source

Trimetazidine and exercise provide comparable improvements to high fat diet-induced muscle dysfunction through enhancement of mitochondrial quality control

Scientific Reports, 2021
Obesity induces skeletal muscle dysfunction. The pathogenesis of which appears to substantially involve mitochondrial dysfunction, arising from impaired quality control. Exercise is a major therapeutic strategy against muscle dysfunction.
Wenliang Zhang, Baiyang You, Dake Qi, Ling Qiu, Jeffrey W. Ripley-Gonzalez, Fan Zheng, Siqian Fu, Cui Li, Yaoshan Dun, Suixin Liu   +9 more
doaj   +1 more source

Determination of trimetazidine in urine by capillary electrophoresis with amperometric detection

Chemical Monthly, 2023
In this contribution, nonaqueous capillary electrophoresis with end-column amperometric detection using a platinum ultramicroelectrode is presented along with several extraction procedures, both liquid–liquid extraction (LLE) and solid-phase extraction ...
Martin Baroch, H. Dejmková, F. Matysik
semanticscholar   +1 more source

Comparison of Cardioprotective Effects of Dapagliflozin and Trimetazidine in the Model of Doxorubicin-Cyclophosphamide Cardiotoxicity

Innovative Medicine of Kuban, 2023
Background: Data published by task groups of the Ministry of Health of the Russian Federation, the European Society of Cardiology, and other medical associations and institutions show that chemotherapy-induced cardiomyopathy is still a challenging issue ...
©А.А. Авагимян, А.И. Трофименко, М. Шейбани, Л.В. Кактурский, О.И. Уразова, Г.А. Навасардян, З.Т. Джндоян, Н.В. Сулашвили, Л.И. Габуния, Н.С. Горгаслидзе, Ф.М. Хамидова, Л.А. Мартемьянова, Н.В. Погосова, Н. Саррафзадеган, A. Avagimyan, Artem Trofimenko, Mohammad Sheibani, L. Kakturskiy, O. Urazova, G. Navasardyan, Z. Jndoyan, Nodar Sulashvili, Luiza Gabunia, Nana S. Gorgaslidze, F. M. Khamidova, L. A. Martemyanova, Nana Pogosova, Nizal Sarrafzadegan   +27 more
semanticscholar   +1 more source

Trimetazidine Affects Mitochondrial Calcium Uniporter Expression to Restore Ischemic Heart Function via Reactive Oxygen Species/NFκB Pathway Inhibition

Journal of Cardiovascular Pharmacology, 2023
Supplemental Digital Content is Available in the Text. Abstract: Studies have demonstrated the roles of trimetazidine beyond being an antianginal agent in ischemic heart disease (IHD) treatment associated with mechanisms of calcium regulation. Our recent
Zilong Xiao, Lichun Guan, Hui Shi, Yong Yu, Ziqing Yu, Shengmei Qin, Yangang Su, Ruizhen Chen, Ming-hui Li, Junbo Ge   +9 more
semanticscholar   +1 more source

Use of a gene expression signature to identify trimetazidine for repurposing to treat bipolar depression

Bipolar Disorders, 2023
The aim of this study was to repurpose a drug for the treatment of bipolar depression.
C. Bortolasci, Srisaiyini Kidnapillai, Briana Spolding, Trang T. T. Truong, T. Connor, C. Swinton, B. Panizzutti, Zoe S J Liu, A. Sanigorski, O. Dean, T. Crowley, M. Richardson, K. Bozaoglu, K. Vlahos, S. Cowdery, Brad Watmuff, S. Steyn, D. W. Wolmarans, Barend J Engelbrecht, Christina J. Perry, Katherine D Drummond, T. Pang, S. Jamain, L. Gray, S. McGee, B. Harvey, Jee Hyun Kim, M. Leboyer, Michael Berk, K. Walder   +29 more
semanticscholar   +1 more source