Results 21 to 30 of about 12,230 (281)

Cardioprotective Effects of Dapagliflozin and Trimetazidine on Doxorubicin-Induced Cardiotoxicity in Streptozotocin-Induced Type 1 Diabetic Rats via Endoplasmic Reticulum Stress. [PDF]

J Clin Med
Ogutveren MM, Satiroglu O, Ozden Z, Akyildiz K, Yilmaz A, Mercantepe F, Yilmaz AS, Koc H, Mercantepe T.   +8 more
europepmc   +2 more sources

Metabolic study of trimetazidine using ultra-high performance liquid chromatography-tandem mass spectrometry [PDF]

Brazilian Journal of Pharmaceutical Sciences, 2023
In the present study, the application of ultra-high performance liquid chromatography-tandem mass spectrometry allowed us to study of known-as well as hitherto unknown-trimetazidine (TMZ) metabolites in human urine and to propose their renal excretion ...
Kamila Chomaničová, Élida Alechaga Silva, Rosa Ventura Alemany   +2 more
doaj   +1 more source

Clinicohemodynamic efficacy of a selective beta-blocker bisoprolol and cytoprotector trimetazidine in the treatment of chronic cardiac failure in patients with ischemic heart disease

Терапевтический архив, 2004
Aim. To assess the effect of a long-term (6 months) treatment with selective beta-blocker bisoprolol, cytoprotector trimetazidine and their combination on the clinical course, left ventricular morphofunctional parameters and quality of life of patients ...
Т A Fedorova, Yu V Ilyina, Т I Sotnikova, M К Rybakova, N V Loschits   +4 more
doaj   +1 more source

Trimetazidine protects against smoking-induced left ventricular remodeling via attenuating oxidative stress, apoptosis, and inflammation. [PDF]

PLoS ONE, 2012
Trimetazidine, a piperazine derivative used as an anti-anginal agent, improves myocardial glucose utilization through inhibition of fatty acid metabolism.
Xiang Zhou, Chao Li, Weiting Xu, Jianchang Chen   +3 more
doaj   +1 more source

Combined β-sitosterol and trimetazidine mitigate potassium dichromate-induced cardiotoxicity in rats through the interplay between NF-κB/AMPK/mTOR/TLR4 and HO-1/NADPH signaling pathways

Environmental science and pollution research international, 2023
Hexavalent chromium salt, like potassium dichromate (PD), is chromium’s most precarious valence state in industrial wastes. Recently, there has been increasing interest in β-sitosterol (BSS), a bioactive phytosterol, as a dietary supplement.
Ehab A. M. El-Shoura, M. A. Salem, Yasmine H. Ahmed, Lamiaa Khalaf Ahmed, Dalia K. Zaafar   +4 more
semanticscholar   +1 more source

Efficacy of Trimetazidine Dihydrochloride for Relieving Chronic Tinnitus: A Randomized Double-Blind Study [PDF]

Clinical and Experimental Otorhinolaryngology, 2016
Objectives. To evaluate the efficacy of trimetazidine dihydrochloride as a treatment for chronic tinnitus. Methods. A total of 97 chronic tinnitus patients were evaluated in this randomized, prospective, double-blind, placebo-controlled trial.
Tolgar Lütfi Kumral, Güven Yıldırım, Güler Berkiten, Ziya Saltürk, Enes Ataç, Yavuz Atar, Yavuz Uyar   +6 more
doaj   +1 more source

Trimetazidine in heart failure with preserved ejection fraction: a randomized controlled cross‐over trial

ESC Heart Failure, 2023
Impaired myocardial energy homeostasis plays an import role in the pathophysiology of heart failure with preserved ejection fraction (HFpEF). Left ventricular relaxation has a high energy demand, and left ventricular diastolic dysfunction has been ...
A. A. Bovenkamp, K. J. Geurkink, Frank T Oosterveer, Frances S. Man, Wouter E.M. Kok, Patrick N.A. Bronzwaer, Cor P. Allaart, A. Nederveen, Albert C. Rossum, A. Bakermans, M. Louis Handoko   +10 more
semanticscholar   +1 more source

Metabolic regulation to treat bipolar depression: mechanisms and targeting by trimetazidine

Molecular Psychiatry, 2023
Bipolar disorder’s core feature is the pathological disturbances in mood, often accompanied by disrupted thinking and behavior. Its complex and heterogeneous etiology implies that a range of inherited and environmental factors are involved.
Sourav Khanra, P. Reddy, Anna Giménez-Palomo, C. H. J. Park, B. Panizzutti, Madeleine McCallum, S. Arumugham, S. Umesh, M. Debnath, B. Das, G. Venkatasubramanian, M. Ashton, A. Turner, O. Dean, K. Walder, E. Vieta, L. Yatham, I. Pacchiarotti, Y. Reddy, N. Goyal, M. Kesavan, L. Colomer, Michael Berk, Jee Hyun Kim   +23 more
semanticscholar   +1 more source

Revisiting the role of trimetazidine for peripheral artery disease: a systematic review with meta-analysis

JPMA. The Journal of the Pakistan Medical Association
OBJECTIVE To examine the impact of trimetazidine on skeletal muscle function in patients suffering from peripheral artery disease. METHODS The systematic review was conducted from July 20 to November 22, 2022, in line with the Preferred Reporting Items
Raden Mohammad Budiarto, Pandit Bagus Tri Saputra, Roy Bagus Kurniawan, Dinda Dwi Purwati, A. Haq, Citrawati Dyah Kencono Ungu   +5 more
openalex   +3 more sources

Effects of Trimetazidine on Right Ventricular Function and Ventricular Remodeling in Patients with Pulmonary Artery Hypertension: A Randomised Controlled Trial

Journal of Clinical Medicine, 2023
Background: Pulmonary artery hypertension (PAH) is a chronic and progressive disease. Although current therapy has improved the disease prognosis, PAH has a poor survival rate. The key feature leading to disease progression and death is right ventricular
H. Verdejo, Adolfo Rojas, Camila López-Crisosto, Fernando Baraona, L. Gabrielli, V. Maracaja-Coutinho, M. Chiong, S. Lavandero, P. Castro   +8 more
semanticscholar   +1 more source