Results 41 to 50 of about 12,230 (281)

Present and future pharmacotherapeutic agents in heart failure: an evolving paradigm [PDF]

, 2016
Many conditions culminate in heart failure (HF), a multi-organ systemic syndrome with an intrinsically poor prognosis. Pharmacotherapeutic agents that correct neurohormonal dysregulation and haemodynamic instability have occupied the forefront of ...
Abozguia, AIRE Study Group, Alexander, Alexander, Alexander, Alexander, Ashrafian, Bailey, Bailey, Basu, Beadle, Braunwald, Brown, Burgoyne, Chaitman, Chatterjee, Chung, CIBIS-II Study Group, Cleland, Clerc, Cohn, Cohn, Cohn, CONSENSUS Trial Study Group, Conway, Cook, Dai, Digitalis Investigation Group, Doenst, Dzau, Dzau, Faris, Flather, Follath, Foster, Fox, Fox, Fragasso, Furberg, Gheorghiade, Gladwin, Goffart, Granger, Greenberg, Guazzi, Guazzi, Heymans, Hobbs, Holubarsch, Horowitz, Horowitz, Kantor, Kapil, Kato, Kennedy, Kennedy, Kostis, Larsen, Lee, Lopaschuk, Luiken, Lundberg, Maher, Maier, Mancini, Mann, Mann, Massie, Mccormack, Mcdowell, Mcmurray, Mcmurray, Merit-Hf Study Group, Munzel, Munzel, Neglia, Neubauer, Ormerod, Packer, Packer, Paul, Pawson, Pfeffer, Pfeffer, Pitt, Pitt, Rathore, Rauchhaus, Redfield, Rona, Sack, Sarraf, Schmidt-Schweda, Schrauwen, Schwarz, Shah, Shah, Siddiqi, Singh, SOLVD Investigators, Stanley, Swedberg, Szwed, Taylor, Teerlink, Tilemann, Torre-Amione, Totzeck, Turcani, Unger, Van Der Vusse, Van Faassen, Vardeny, Webb, Yin, Yusuf, Zamani, Zannad, Zannad, Zhang   +119 more
core   +1 more source

The effectiveness of cytocardioprotection of patients with the moderately expressed post infarct dysfunction of left heart ventricle: the results of the randomization research of trimetazidine and athenolole

Бюллетень сибирской медицины, 2002
With the purpose of research of clinical efficiency of trimetazidine and atenolol and their influence on morfofunctional parameteres of left ventricle 36 men who have transferred a myocardial infarction are inspected.
V. V. Kalyuzhin, M. A. Solovtsov, D. U. Kamaev   +2 more
doaj   +1 more source

Trimetazidine Ameliorates Myocardial Metabolic Remodeling in Isoproterenol-Induced Rats Through Regulating Ketone Body Metabolism via Activating AMPK and PPAR α

Frontiers in Pharmacology, 2020
BackgroundMetabolic remodeling plays a vital role in the development of heart failure. The trimetazidine can optimize fatty acid and glucose oxidation via inhibition of long-chain 3-ketoacyl CoA thiolase in the heart.
Huihui Li, Huihui Li, Zhi Ma, Yajun Zhai, Chao Lv, Peng Yuan, Feng Zhu, Liping Wei, Qi Li, Xin Qi   +9 more
doaj   +1 more source

Intracoronary trimetazidine does not improve recovery of regional function in a porcine model of repeated ischemia [PDF]

, 1993
We evaluated the effect of trimetazidine (TMZ) on recovery of regional cardiac function in anesthetized open-chest pigs, subjected to fifteen 2-minute occlusions of the left anterior descending coronary artery, separated by 2 minutes of reperfusion and a
Bezstarosti, K. (Karel), Koning, M.M.G. (Monique), Krams, R. (Rob), Lamers, J.M.J. (Jos), Meegen, J.R. (Jan) van, Verdouw, P.D. (Pieter), Xiao, C.S. (C.)   +6 more
core   +1 more source

Defining the Role of Trimetazidine in the Treatment of Cardiovascular Disorders: Some Insights on Its Role in Heart Failure and Peripheral Artery Disease [PDF]

, 2014
Trimetazidine is a cytoprotective drug whose cardiovascular effectiveness, especially in patients with stable ischemic heart disease, has been the source of much controversy in recent years; some have gone so far as to treat the medication as a ‘placebo ...
Jacek Rysz, Maciej Banach, Piotr Chrusciel   +2 more
core   +1 more source

Role of Trimetazidine in Ameliorating Endothelial Dysfunction: A Review. [PDF]

Pharmaceuticals (Basel)
Endothelial dysfunction is a hallmark of cardiovascular diseases, contributing to impaired vasodilation, altered hemodynamics, and atherosclerosis progression. Trimetazidine, traditionally used for angina pectoris, exhibits diverse therapeutic effects on
Kamisah Y, Che Hassan HH.
europepmc   +2 more sources

Efficacy of Trimetazidine in the Prevention of Contrast-Induced Nephropathy in Patients Undergoing Contrast Coronary Intervention: A Systematic Review and Meta-Analysis (PRISMA). [PDF]

J Clin Med
Objective: The present systematic review assessed the efficacy of peri-procedurally administered trimetazidine in the prevention of contrast-induced nephropathy (CIN) in patients undergoing coronary interventions with contrast agents.
Nair T, Ray S, George J, Pande A.
europepmc   +2 more sources

Expert consensus document: A 'diamond' approach to personalized treatment of angina. [PDF]

, 2017
In clinical guidelines, drugs for symptomatic angina are classified as being first choice (β-blockers, calcium-channel blockers, short-acting nitrates) or second choice (ivabradine, nicorandil, ranolazine, trimetazidine), with the recommendation to ...
A Abbate, A Daiber, A Maseri, AD Timmis, AJ Camm, AJ Camm, AJ Manolis, AK Gupta, Aldo P. Maggioni, Athanasios J. Manolis, BM Scirica, C Andersson, CA Salazar, CF George, CN Bairey Merz, D Gao, DA Morrow, E Amosova, E Antman, E Rayner-Hartley, E Tagliamonte, E Tagliamonte, E Vidal-Petiot, EP Tsika, F Crea, FH Rutten, Filippo Crea, G Ambrosio, G Fragasso, G Weisz, GA Lanza, GB Mancini, Giuseppe M. C. Rosano, H Suryapranata, HC McGill Jr, HG Booij, IA Vermeltfoort, J Belsey, JA Reiffel, JC Tardif, JC Tardif, JG McCormack, JM Detry, JM Miller, José L. Lopez-Sendon, JS Borer, JS Borer, K Fox, K Fox, K Fox, K Fox, K Fox, K Schnell, K Stergiopoulos, K Swedberg, K Werdan, Kim Fox, KJ McClellan, L Simon, M Cattaneo, M Jerling, M Kosiborod, M Marzilli, MA Marinescu, Mario Marzilli, N Danchin, ND Masini, Nicolas Danchin, P Ponikowski, PA Heidenreich, PA Poole-Wilson, Paolo G. Camici, PF Kantor, PK Mehta, R Ferrari, R Ferrari, R Venkataraman, RI Martin, Roberto Ferrari, S Bangalore, S Bangalore, S De Leo, S Gloekler, S Peng, SC Paravastu, SD Fihn, SE Husted, SG Chrysant, ST O'Rourke, T Sedlak, TK Paul, TM Maddox, U Thadani, U Thadani, U Thadani, U Thadani, U Thadani, U Thadani, W Ruzyllo, WJ Elliott, WR Hiatt, X Xu   +101 more
core   +1 more source

Targeting Metabolic Modulation and Mitochondrial Dysfunction in the Treatment of Heart Failure [PDF]

, 2017
Despite significant improvements in morbidity and mortality with current evidence-based pharmaceutical-based treatment of heart failure (HF) over the previous decades, the burden of HF remains high.
Li, Mann, Morrow, Murray, Sabbah, Zhang
core   +2 more sources

Trimetazidine mitigates high glucose-induced retinal endothelial dysfunction by inhibiting PI3K/Akt/mTOR pathway-mediated autophagy

Bioengineered, 2022
Trimetazidine (TMZ), as a metabolic regulator, has been widely testified to exhibit positive therapeutic effects on various disease models, but its role in diabetic retinopathy has not been reported. Therefore, this study was designed with the purpose of
Qingsong Yang, Sizhen Li, Zixiu Zhou, Xiaodong Yang, Yating Liu, Kuanxiao Hao, M. Fu   +6 more
semanticscholar   +1 more source