Results 51 to 60 of about 12,013 (243)

The mitochondrial metabolic reprogramming agent trimetazidine as an 'exercise mimetic' in cachectic C26-bearing mice. [PDF]

, 2017
BACKGROUND: Cancer cachexia is characterized by muscle depletion and exercise intolerance caused by an imbalance between protein synthesis and degradation and by impaired myogenesis. Myofibre metabolic efficiency is crucial so as to assure optimal muscle
Acharyya, Anker, Baar, Baar, Barany, Booth, Bowen, Brooks, Calabria, Cervelli, Chinsomboon, Coats, Condon, De Zio, Del Prete, Drescher, Edelmann, Egan, Evans, Ferraro, Ferraro, Ferraro, Ferraro, Ferraro, Fragasso, Fragasso, Fukawa, Gaffney, Grande, Gundersen, Guttridge, Haehling, Haehling, Haehling, Hawley, Heymsfield, Irrcher, Irwin, Iwata, Jahnke, Jaswal, Kantor, Khodabukus, Komajda, Lecker, Lenk, Lerner, Lin, Lira, Livak, Lodka, Long, Lopaschuk, Lopatin, Mammucari, Marazzi, Marino, Milone, Molinari, Montagna, Moreno, Narkar, Palus, Penna, Penna, Pilegaard, Pin, Proud, Puigserver, Rosano, Ruas, Ryder, Sanders, Sandri, Schiaffino, Schiaffino, Schiaffino, Schneider, Talbert, Tan, Tanaka, Tocchetti, Vitale, Wang, Widegren, Zierath   +85 more
core   +3 more sources

Adalékok az időskori maculadegeneráció – etiopatogeneziséből fakadó – gyógyszeres intervenciójához [PDF]

, 2015
Absztrakt A szem struktúráit vérrel ellátó érendothelium működészavarának kulcsfontosságú szerepe van az időskori maculadegeneráció létrejöttében.
Fischer, Tamás
core   +1 more source

Effects of Trimetazidine Pretreatment on Endothelial Dysfunction and Myocardial Injury in Unstable Angina Patients Undergoing Percutaneous Coronary Intervention

Cardiology Research and Practice, 2019
Objectives. Trimetazidine is an anti-ischemic medication licensed for the treatment of angina pectoris. However, the molecular mechanisms underlying its action remain incompletely elucidated. In this study, therefore, we examined the potential beneficial
Shuai Shao, Zhaozhao Shi, Gary Tse, Xinghua Wang, Yanping Ni, Hongmei Liu, Tong Liu, Guangping Li   +7 more
doaj   +1 more source

Effect of trimetazidine on myocardial salvage index in patients with acute ST segment elevation myocardial infarction undergoing primary PCI

The Egyptian Heart Journal, 2013
Introduction: Acute STEMI is the most serious presentation of CAD. Restoration of the coronary flow facilitates cardiomyocyte salvage and decreases cardiac morbidity and mortality. However, reperfusion may result in paradoxical cardiomyocyte dysfunction,
Foad Khaled, Elmahmoudy Ahmed, Bastawy Islam, Khaled Saeed   +3 more
doaj   +1 more source

Trimetazidine in Heart Failure

Frontiers in Pharmacology, 2021
Heart failure is a systemic syndrome caused by multiple pathological factors. Current treatments do not have satisfactory outcomes. Several basic studies have revealed the protective effect of trimetazidine on the heart, not only by metabolism modulation
Hongyang Shu, Yizhong Peng, Weijian Hang, N. Zhou, Daowen Wang   +4 more
semanticscholar   +1 more source

Biochemical Aspects That Lead to Abusive Use of Trimetazidine in Performance Athletes: A Mini-Review

International Journal of Molecular Sciences
Trimetazidine (TMZ), used for treating stable angina pectoris, has garnered attention in the realm of sports due to its potential performance-enhancing properties, and the World Anti-Doping Agency (WADA) has classified TMZ on the S4 list of prohibited ...
Amalia Pușcaș, Ruxandra Ștefănescu, C. Vari, Bianca-Eugenia Ősz, Cristina Filip, Jana Karlina Bitzan, Mădălina-Georgiana Buț, Amelia Tero-Vescan   +7 more
semanticscholar   +1 more source

Cardiac metabolism — A promising therapeutic target for heart failure [PDF]

, 2017
Both heart failure with reduced ejection fraction (HFrEF) and with preserved ejection fraction (HFpEF) are associated with high morbidity and mortality.
Frenneaux, Michael P, Loudon, Brodie L, Madhani, Melanie, Noordali, Hannah   +3 more
core   +2 more sources

The cystathionine γ-lyase/hydrogen sulfide pathway mediates the trimetazidine-induced protection of H9c2 cells against hypoxia/reoxygenation-induced apoptosis and oxidative stress

Anatolian Journal of Cardiology, 2019
Objective: Trimetazidine is a piperazine-derived metabolic agent. It exerts cardioprotective effects against myocardial ischemia/reperfusion (I/R) injury.
Wenqing Zheng, Chao Liu
doaj   +1 more source

Effects of Glucose Concentration on Propofol Cardioprotection against Myocardial Ischemia Reperfusion Injury in Isolated Rat Hearts [PDF]

, 2015
published_or_final_versio
Li, Y, Lin, J, Liu, HM, Tao, M, Wang, S, Xia, Z, Yao, X, Zhang, L   +7 more
core   +3 more sources

Trimetazidine improves left ventricular global longitudinal strain value in patients with heart failure with reduced ejection fraction due to ischemic heart disease.

Drug Discoveries & Therapeutics, 2022
Heart failure with reduced ejection fraction (HFrEF) due to ischemic heart disease (IHD) showed a progressive decline in left ventricular contractile function.
Rille Puspitoadhi Harjoko, M. A. Sobirin, I. Uddin, U. Bahrudin, N. Maharani, S. Herminingsih, H. Tsutsui   +6 more
semanticscholar   +1 more source