Results 51 to 60 of about 12,230 (281)

АТP as the marker of power exchange condition at the experimental ischemia of the myocardium due to metabolic drugs introduction [PDF]

, 2016
For the purpose of definition of an adequate marker of a power exchange condition at the experimental ischemia of the myocardium due introduction of metabolic drugs, the experimental research on 60 rats-males of Wistar line has been spent.
Gorbach, T. V., Kukes, V. G., Romashchenko, O. V., Rumbesht, V. V.   +3 more
core   +2 more sources

The Impact of Trimetazidine on Cardiac Fibrosis, Inflammation, and Function in Ischemic Cardiomyopathy Patients

Cardiovascular Drugs and Therapy, 2022
Background Previous studies have shown that Trimetazidine (TMZ) improves vascular endothelial function and reduces the inflammatory process progression.
N. El-khodary, A. Ghoneim, Ahmed A. El-tayaar, Eman M. El-touny   +3 more
semanticscholar   +1 more source

The mitochondrial metabolic reprogramming agent trimetazidine as an 'exercise mimetic' in cachectic C26-bearing mice. [PDF]

, 2017
BACKGROUND: Cancer cachexia is characterized by muscle depletion and exercise intolerance caused by an imbalance between protein synthesis and degradation and by impaired myogenesis. Myofibre metabolic efficiency is crucial so as to assure optimal muscle
Acharyya, Anker, Baar, Baar, Barany, Booth, Bowen, Brooks, Calabria, Cervelli, Chinsomboon, Coats, Condon, De Zio, Del Prete, Drescher, Edelmann, Egan, Evans, Ferraro, Ferraro, Ferraro, Ferraro, Ferraro, Fragasso, Fragasso, Fukawa, Gaffney, Grande, Gundersen, Guttridge, Haehling, Haehling, Haehling, Hawley, Heymsfield, Irrcher, Irwin, Iwata, Jahnke, Jaswal, Kantor, Khodabukus, Komajda, Lecker, Lenk, Lerner, Lin, Lira, Livak, Lodka, Long, Lopaschuk, Lopatin, Mammucari, Marazzi, Marino, Milone, Molinari, Montagna, Moreno, Narkar, Palus, Penna, Penna, Pilegaard, Pin, Proud, Puigserver, Rosano, Ruas, Ryder, Sanders, Sandri, Schiaffino, Schiaffino, Schiaffino, Schneider, Talbert, Tan, Tanaka, Tocchetti, Vitale, Wang, Widegren, Zierath   +85 more
core   +3 more sources

Trimetazidine and Other Metabolic Modifiers [PDF]

European Cardiology Review, 2018
Treatment goals for people with chronic angina should focus on the relief of symptoms and improving mortality rates so the patient can feel better and live longer. The traditional haemodynamic approach to ischaemic heart disease was based on the assumption that increasing oxygen supply and decreasing oxygen demand would improve symptoms.
Marzilli, Mario, Giuseppina Capozza, Paola Francesca, Morrone, Doralisa, Huqi, Alda, Guarini, Giacinta   +4 more
openaire   +2 more sources

Trimetazidine Reduces Cardiac Fibrosis in Rats by Inhibiting NOX2-Mediated Endothelial-to-Mesenchymal Transition

Drug Design, Development and Therapy, 2022
Purpose Endothelial-to-mesenchymal transition (EndMT) is an important mechanism underlying cardiac fibrosis. The anti-ischemic drug trimetazidine (TMZ) is reportedly useful in ventricular remodeling and associated with NADPH oxidase (NOX) 2.
Xingxing Chen, Xueting Xia, Tiancheng Dong, Zhiwei Lin, Leilei Du, Hao Zhou   +5 more
semanticscholar   +1 more source

Sirtuin 1 in rat orthotopic liver transplantation: An IGL-1 preservation solution approach [PDF]

, 2015
© The Author(s) 2015. AIM: To investigate the possible involvement of Sirtuin 1 (SIRT1) in rat orthotopic liver transplantation (OLT), when Institute Georges Lopez 1 (IGL-1) preservation solution is enriched with trimetazidine (TMZ).
Abdennebi, Hassen B., Bejaoui, Mohamed, Folch-Puy, Emma, Palmeira, Carlos M., Pantazi, Eirini, Rolo, Anabela Pinto, Roselló-Catafau, Joan, Varela, Ana Teresa, Zaouali, Mohamed A.   +8 more
core   +2 more sources

Trimetazidine and exercise offer analogous improvements to the skeletal muscle insulin resistance of mice through Nrf2 signaling

BMJ Open Diabetes Research & Care, 2022
Introduction Insulin resistance (IR) plays a key role in the pathogenesis and clinical course of patients with multiple metabolic diseases and diabetes.
Wenliang Zhang, Yaoshan Dun, Baiyang You, Ling Qiu, J. W. Ripley-Gonzalez, Jing Cheng, Siqian Fu, Cui Li, Suixin Liu   +8 more
semanticscholar   +1 more source

Triple antianginal combinations in the treatment of elderly and senile patients with stable angina [PDF]

Терапевтический архив, 2016
Aim. To compare the efficiency and safety of antianginal therapy (AAT) using a combination of bisoprolol, ivabradine, and trimetazidine or ranolazine in elderly and senile patients with stable angina. Subjects and methods. The study enrolled 107 patients
S G Kanorskii, N V Smolenskaya
doaj   +1 more source

Adalékok az időskori maculadegeneráció – etiopatogeneziséből fakadó – gyógyszeres intervenciójához [PDF]

, 2015
Absztrakt A szem struktúráit vérrel ellátó érendothelium működészavarának kulcsfontosságú szerepe van az időskori maculadegeneráció létrejöttében.
Fischer, Tamás
core   +1 more source

Trimetazidine inhibits liver fibrosis and hepatic stellate cell proliferation and blocks transforming growth factor-β (TGFβ)/Smad signaling in vitro and in vivo

Bioengineered, 2022
Trimetazidine (TMZ) has been used extensively to treat coronary artery disease and to reduce fibrosis. Liver fibrosis is a reversible process. However, the impacts of TMZ on liver fibrosis triggered by CCl4 and on hepatic stellate cells in liver fibrosis
Wenwen Ding, Danhua Zhou, Shimeng Zhang, Jiaping Qian, Lingxia Yang, Lei Tang   +5 more
semanticscholar   +1 more source