Results 241 to 250 of about 139,001 (302)

Mechanisms of Resistance to Trimethoprim, the Sulfonamides, and Trimethoprim-Sulfamethoxazole

Clinical Infectious Diseases, 1982
A variety of different mechanisms are known to be responsible for either natural or acquired resistance to trimethoprim, the sulfonamides, or trimethoprim-sulfonamide combinations. Some mechanisms of obvious clinical importance have been studied intensively. Among these are unique bypass mechanisms such as the synthesis of drug-resistant, plasmid-coded
R L Then
exaly   +3 more sources

Trimethoprim-Sulfamethoxazole

Mayo Clinic Proceedings, 1983
The antimicrobial combination of trimethoprim and sulfamethoxazole is active in vitro against a variety of gram-positive and gram-negative bacteria. Clinically, it is useful for treatment and prophylaxis of various infections of the genitourinary tract and certain infections of the respiratory and gastrointestinal tracts.
F R, Cockerill, R S, Edson
openaire   +6 more sources

Degradation of Trimethoprim

Journal of Pharmaceutical Sciences, 1989
Trimethoprim undergoes thermally and photochemically catalyzed hydrolysis or oxidation to give rise to at least five products. The structures of these compounds were determined by physical methods and it was found that the resonance of C-5 in the 13C NMR spectrum is indicative of the substitution pattern of the resultant amino hydroxy pyrimidines.
J J, Bergh, J C, Breytenbach, P L, Wessels   +2 more
openaire   +2 more sources