Results 51 to 60 of about 123,230 (304)

Conformational Snapshots of CydDC in a Native Lipid Bilayer Coupling Heme Transport to Antibiotic Resistance

Advanced Science, EarlyView.
Phylogenetic and biochemical analyses of the heme transporter CydDC reveal its functional conservation throughout bacterial evolution and demonstrate its unique asymmetric allosteric mechanism. Furthermore, impairment of CydDC function directly affects bacterial antibiotic resistance and likely compromises antibiotic efficacy through drug efflux.
Lili Yang, Changbin Zhang, Mengyuan Lyu, Yongbo Luo, Jierou Zhang, Yujiao Chen, Lintao Luo, Wen Qiao, Xiangyangpeng Li, Yu Zhou, Zhongling Wei, Yuling Xiao, Qian Niu, Juan Zhou, Guanglin He, Binwu Ying, Zhaoming Su, Hao Chen, Xiaodi Tang, Haohao Dong   +19 more
wiley   +1 more source

Regional Differences in Penetration of the Protein Stabilizer Trimethoprim (TMP) in the Rat Central Nervous System

Frontiers in Molecular Neuroscience, 2020
Regulating gene expression at the protein level is becoming increasingly important for answering basic questions in neurobiology. Several techniques using destabilizing domains (DD) on transgenes, which can be activated or deactivated by specific drugs ...
Benjamin V. Ineichen, Serena Di Palma, Endre Laczko, Shane A. Liddelow, Shane A. Liddelow, Shane A. Liddelow, Susanne Neumann, Martin E. Schwab, Alice C. Mosberger   +8 more
doaj   +1 more source

Maladaptive DNA repair is the ultimate contributor to the death of trimethoprim-treated cells under aerobic and anaerobic conditions

Proceedings of the National Academy of Sciences of the United States of America, 2017
Significance Antibiotic resistance leads to substantial mortality and morbidity and significant economic cost because it seriously undermines our ability to treat bacterial infections.
X. Giroux, W. Su, M. Bredèche, I. Matic   +3 more
semanticscholar   +1 more source

Identification of antibiotic allergies in children using prescribing patterns in the electronic medical record

British Journal of Clinical Pharmacology, EarlyView.
Background By age three, 5%–75% of children have a documented antibiotic allergy (AL). Despite this prevalence, recognition remains low because of limited clinician knowledge and time. Our study evaluates a novel approach to identifying AL using electronic medical record (EMR) prescription patterns.
Georgia Koutsaplis, Kailey Tang, Renee Dimond, Alice Lei, Amanda Wilkins, Amanda Gwee   +5 more
wiley   +1 more source

EXPERIMENTAL DESIGN-BASED OPTIMIZATION APPROACHES IN UPLC METHOD DEVELOPMENT: SIMULTANEOUS QUANTITATIVE ESTIMATION OF SULFADIAZINE AND TRIMETHOPRIM IN A COMBINED VETERINARY FORMULATION

Studia Universitatis Babes-Bolyai Chemia
This study reports a comparative application of three different experimental designs to develop ultra-performance liquid chromatography (UPLC) methods for simultaneous quantification of sulfadiazine and trimethoprim in veterinary tablets. The effects of
Zehra Ceren ERTEKİN, Erdal DİNÇ
doaj   +1 more source

Trimethoprim–Sulfamethoxazole versus Placebo for Uncomplicated Skin Abscess

New England Journal of Medicine, 2016
BACKGROUND U.S. emergency department visits for cutaneous abscess have increased with the emergence of methicillin-resistant Staphylococcus aureus (MRSA). The role of antibiotics for patients with a drained abscess is unclear.
D. Talan, W. Mower, A. Krishnadasan, F. Abrahamian, F. LoVecchio, D. Karras, M. Steele, R. Rothman, R. Hoagland, G. Moran   +9 more
semanticscholar   +1 more source

Precision Chemistry for Protein Lysine Modification

Chemistry – A European Journal, EarlyView.
Selective modification of lysine residues is challenging due to their similar intrinsic reactivity. Inspired by enzymatic recognition, ligand‐guided electrophiles enable site‐selective labeling and functionalization, while ligand‐guided catalyses achieve regioselective installation of bio‐relevant post‐translational modifications.
Mayu Onoda, Motomu Kanai
wiley   +1 more source

Novel trimethoprim resistance gene dfrA34 identified in Salmonella Heidelberg in the USA

Journal of Antimicrobial Chemotherapy, 2018
Background: Trimethoprim/sulfamethoxazole is a synthetic antibiotic combination recommended for the treatment of complicated non-typhoidal Salmonella infections in humans.
K. Tagg, L. F. Francois Watkins, M. Moore, Christy Bennett, Y. J. Joung, Jessica C. Chen, J. Folster   +6 more
semanticscholar   +1 more source

Effects of Trimethoprim on Three Previously Proposed Putative Biomarkers for OCT2/MATE‐Mediated Renal Drug‐Drug Interactions in Healthy Volunteers

Clinical Pharmacology &Therapeutics, EarlyView.
Regulatory agencies request the assessment of the potential of new drugs to cause transporter‐mediated drug‐drug interactions (DDI). This assessment can be improved by integrating endogenous biomarkers during drug development. Regarding the renal excretion of drugs such as metformin, the organic cation transporter (OCT) 2 and multidrug and toxin ...
Jana Picurová, Fabian Müller, Daniel Auge, Jörg König, Martin F. Fromm, Arne Gessner   +5 more
wiley   +1 more source

Novel Trimethoprim-Based Metal Complexes and Nanoparticle Functionalization: Synthesis, Structural Analysis, and Anticancer Properties

Inorganics
In this study, we synthesized a novel trimethoprim derivative, 4-(((2-amino-5-(3,4,5-trimethoxybenzyl) pyrimidine-4-yl)imino)methyl)benzene-1,3-diol (HD), by the reaction of trimethoprim with 2,4-dihydroxybenzaldehyde. We then prepared metal complexes of
Abbas M. Abbas, Hossam H. Nasrallah, A. Aboelmagd, W. Christopher Boyd, Haitham Kalil, Adel S. Orabi   +5 more
doaj   +1 more source