Results 51 to 60 of about 99,360 (296)

EXPERIMENTAL DESIGN-BASED OPTIMIZATION APPROACHES IN UPLC METHOD DEVELOPMENT: SIMULTANEOUS QUANTITATIVE ESTIMATION OF SULFADIAZINE AND TRIMETHOPRIM IN A COMBINED VETERINARY FORMULATION

Studia Universitatis Babes-Bolyai Chemia
This study reports a comparative application of three different experimental designs to develop ultra-performance liquid chromatography (UPLC) methods for simultaneous quantification of sulfadiazine and trimethoprim in veterinary tablets. The effects of
Zehra Ceren ERTEKİN, Erdal DİNÇ
doaj   +1 more source

Leveraging Administrative Health Data to Capture Rare Adverse Drug Reactions: Identifying Pediatric Patients With Trimethoprim-Sulfamethoxazole Acute Respiratory Distress Syndrome. [PDF]

Pharmacol Res Perspect
ABSTRACT Rare adverse drug reactions (ADRs) are underrecognized and underreported in the electronic medical record (EMR). These events often require clinical review, making systematic identification challenging. The study aim was to develop an approach to prioritize identification and validation of a rare ADR to trimethoprim‐sulfamethoxazole causing ...
Feldman K, Miller JO, Doane K, Loftis L, Antoon JW, Downes KJ, Goldman JL.   +6 more
europepmc   +2 more sources

Evaluation of Veterinary-Specific Interpretive Criteria for Susceptibility Testing of Streptococcus equi Subspecies with Trimethoprim-Sulfamethoxazole and Trimethoprim-Sulfadiazine

, 2017
Antimicrobial susceptibility test results for trimethoprim-sulfadiazine with Streptococcus equi subspecies are interpreted based on human data for trimethoprim-sulfamethoxazole.
Sadaka, Carmen, Guardabassi, Luca, Watts, Jeffrey L., Kanellos, Theo, Boucher, Joseph   +4 more
core   +1 more source

A Review of Virtual Twins in Physiologically‐Based Pharmacokinetic Modeling and Simulation

Clinical Pharmacology &Therapeutics, EarlyView.
The novel application of Virtual Twins (VT) in PBPK (VT‐PBPK) presents the opportunity to advance precision dosing and accelerate the shift from one‐size‐fits‐all to targeted, individualized treatments. This review aims to: (1) critically evaluate existing research on the use of VTs in PBPK, (2) develop a conceptual definition of VT‐PBPK, (3) describe ...
Emily Mannix, Sam Mostafa, Amin Rostami‐Hodjegan, Thomas M. Polasek, Carl M. J. Kirkpatrick   +4 more
wiley   +1 more source

Novel Trimethoprim-Based Metal Complexes and Nanoparticle Functionalization: Synthesis, Structural Analysis, and Anticancer Properties

Inorganics
In this study, we synthesized a novel trimethoprim derivative, 4-(((2-amino-5-(3,4,5-trimethoxybenzyl) pyrimidine-4-yl)imino)methyl)benzene-1,3-diol (HD), by the reaction of trimethoprim with 2,4-dihydroxybenzaldehyde. We then prepared metal complexes of
Abbas M. Abbas, Hossam H. Nasrallah, A. Aboelmagd, W. Christopher Boyd, Haitham Kalil, Adel S. Orabi   +5 more
doaj   +1 more source

Formulation and evaluation of sulfadimidine and trimethoprim tablets using wet granulation technique

Current Issues in Pharmacy and Medical Sciences, 2012
The objective of this study was to develop tablet formulations of sulphadimidine sodium (SDD-Na) and trimethoprim (TMP), evaluate and compare the efficiency of some excipients such as: superdisintegrant - croscarmellose sodium (Ac-Di-Sol), silicon ...
Łukasz Zimmer, Katarzyna Świąder, Piotr Belniak, Michał Szumiło, Maria Zuń, Regina Kasperek, Ewa Poleszak   +6 more
doaj   +1 more source

Innovative Perspectives on Biofilm Interactions in Poultry Drinking Water Systems and Veterinary Antibiotics Used Worldwide

Antibiotics, 2022
Prudent use of antibiotics in livestock is widely considered to be important to prevent antibiotic resistance. This study aimed to evaluate the interactions between biofilms and veterinary antibiotics in therapeutic concentrations administrated via ...
Friederike Hahne, Simon Jensch, Gerd Hamscher, Jessica Meißner, Manfred Kietzmann, Nicole Kemper, Jochen Schulz, Rafael H. Mateus-Vargas   +7 more
doaj   +1 more source

Enzyme inhibition assay using trimethoprim (20 µg/ml) and trimethoprim susceptible S. aureus ATCC 25923.

, 2013
An agar plate section containing trimethoprim (20 µg/ml), was inoculated with trimethoprim susceptible S. aureus ATCC 25923. An agar plug containing the trimethoprim inhibiting soil bacteria were placed into the inoculated trimethoprim agar.
Brion Duffy (103784), Fiona Walsh (420769)   +1 more
core   +1 more source

Effects of Trimethoprim on Three Previously Proposed Putative Biomarkers for OCT2/MATE‐Mediated Renal Drug‐Drug Interactions in Healthy Volunteers

Clinical Pharmacology &Therapeutics, EarlyView.
Regulatory agencies request the assessment of the potential of new drugs to cause transporter‐mediated drug‐drug interactions (DDI). This assessment can be improved by integrating endogenous biomarkers during drug development. Regarding the renal excretion of drugs such as metformin, the organic cation transporter (OCT) 2 and multidrug and toxin ...
Jana Picurová, Fabian Müller, Daniel Auge, Jörg König, Martin F. Fromm, Arne Gessner   +5 more
wiley   +1 more source

Release kinetics of sulfadimidine sodium and trimethoprim from tablets containing different excipients prepared by wet granulation method

Current Issues in Pharmacy and Medical Sciences, 2013
In this study seven tablet batches were prepared by wet granulation process using different excipients such as: superdisintegrant – croscarmellose sodium (Ac- Di- Sol), silicon dioxide (Aerosil), lactose, pregelatinized starch (CPharm Gel) and ...
Łukasz Zimmer, Piotr Belniak, Michał Szumiło, Regina Kasperek, Ewa Poleszak   +4 more
doaj   +1 more source