Results 81 to 90 of about 123,230 (304)

Proteostasis modulates gene dosage evolution in antibiotic-resistant bacteria

eLife
Evolution of gene expression frequently drives antibiotic resistance in bacteria. We had previously (Patel and Matange, eLife, 2021) shown that, in Escherichia coli, mutations at the mgrB locus were beneficial under trimethoprim exposure and led to ...
Chinmaya Jena, Saillesh Chinnaraj, Soham Deolankar, Nishad Matange   +3 more
doaj   +1 more source

Interpretation of Key Updates in the 36th Edition of Clinical and Laboratory Standards Institute M100 Standard

iLABMED, EarlyView.
ABSTRACT The Clinical and Laboratory Standards Institute M100 document serves as a cornerstone standard for clinical microbiology laboratories in China. Maintaining the scientific rigor of its predecessors, the 36th edition incorporates updated epidemiological cutoff values, pharmacokinetic/pharmacodynamic data, and clinical efficacy evidence to revise
Kanghong Xu, Qi Wang, Hui Wang
wiley   +1 more source

The Landscape of Biomarkers in ICU‐Associated AKI: From Protein Markers to Cell‐Free Nucleic Acids

Journal of Clinical Laboratory Analysis, EarlyView.
Acute kidney injury (AKI) in critically ill patients—particularly in sepsis—often develops early and is missed by creatinine/urine output–based criteria, delaying risk stratification and timely intervention. This review synthesizes current evidence on established and emerging AKI biomarkers (e.g., NGAL, KIM‐1, [TIMP‐2]·[IGFBP7]) alongside circulating ...
Qi Zhu, Feng Yang, Hua Zheng, Xinxin Guo, Zhijin Chen, Limin Chen, Daoli Wang, Jiaqi Wang, Xinmeng Wang, Zhiyuan Huang, Zhenhua Ji   +10 more
wiley   +1 more source

Clindamycin versus Trimethoprim–Sulfamethoxazole for Uncomplicated Skin Infections

New England Journal of Medicine, 2015
Background Skin and skin-structure infections are common in ambulatory settings. However, the efficacy of various antibiotic regimens in the era of community-acquired methicillin-resistant Staphylococcus aureus (MRSA) is unclear.
L. Miller, R. Daum, C. Creech, D. Young, M. Downing, S. Eells, Stephanie Pettibone, R. Hoagland, H. Chambers   +8 more
semanticscholar   +1 more source

Dasatinib and quercetin prevent alveolar bone loss in aged mice

Journal of Periodontology, EarlyView.
Abstract Background Recent findings have associated alveolar bone loss (ABL) with the presence of senescent cells. Aging and the accumulation of senescent cells are associated with a pro‐inflammatory environment which may exacerbate tissue damage.
Luisa S. Battistelli, Renata M. Moraes, Yuri C. Santos, Jaqueline L. Ribeiro, Maíra T. Garcia, Renata F. Prado, Florent Elefteriou, Ana Lia Anbinder   +7 more
wiley   +1 more source

Spectrophotometric Estimation of Trimethoprim By Charge Transfer Complex Formation Reaction

Pakistan Journal of Analytical & Environmental Chemistry
A new simple method is proposed for the spectrophotometric estimation of trimethoprim drug (TMP), depending on the formation of an n-π charge transfer complex between TMP acting as n-donor and o-chloranil acting as π-acceptor in ethanolic ...
Theia'a N. Al-Sabha, A. W. Al-Azzawi
doaj   +1 more source

Trimethoprim-sulfamethoxazole versus vancomycin for severe infections caused by meticillin resistant Staphylococcus aureus: randomised controlled trial

British medical journal, 2015
Objective To show non-inferiority of trimethoprim-sulfamethoxazole compared with vancomycin for the treatment of severe infections due to meticillin resistant Staphylococcus aureus (MRSA). Design Parallel, open label, randomised controlled trial. Setting
M. Paul, J. Bishara, D. Yahav, E. Goldberg, A. Neuberger, Nesrin Ghanem-Zoubi, Y. Dickstein, W. Nseir, M. Dan, L. Leibovici   +9 more
semanticscholar   +1 more source

The safe and effective use of tofacitinib and ustekinumab combination therapy in infantile onset inflammatory bowel disease

JPGN Reports, EarlyView.
Abstract Infantile‐onset inflammatory bowel disease (IOIBD) is a rare and severe subset of very‐early‐onset IBD, often associated with immune dysregulation and poor response to conventional therapies. Data regarding the use of Janus kinase inhibitors (JAKI) in this population is limited.
Smridhi Mahajan, Christian Wysocki, Bhaskar Gurram   +2 more
wiley   +1 more source

Occurrence and Dissipation of the Antibiotics Sulfamethoxazole, Sulfadiazine, Trimethoprim, and Enrofloxacin in the Mekong Delta, Vietnam

PLoS ONE, 2015
The Mekong Delta in Vietnam has seen a rapid development and intensification of aquaculture in the last decades, with a corresponding widespread use of antibiotics.
Chau Nguyen Dang Giang, Z. Sebesvari, F. Renaud, Ingrid Rosendahl, Quang Hoang Minh, W. Amelung   +5 more
semanticscholar   +1 more source

Pediatric Clostridiodes difficile infection with toxic megacolon successfully treated with fecal microbiota transplantation

JPGN Reports, EarlyView.
Abstract The rising incidence of pediatric Clostridioides difficile infection (CDI), particularly in medically complex patients, calls for novel, individualized treatments. While fecal microbiota transplantation (FMT) is well‐described for recurrent CDI, this report describes the first pediatric case of fulminant CDI with toxic megacolon successfully ...
Dana McCarney, Pamela Chen, Jenna Simes, Stacy A. Kahn   +3 more
wiley   +1 more source