Results 251 to 260 of about 453,912 (274)

The Gut Microbial Metabolite Trimethylamine N-oxide, Incident CKD, and Kidney Function Decline

Journal of the American Society of Nephrology
Visual Abstract Key Points In community-based US adults, higher plasma trimethylamine N-oxide levels associated with higher risk of incident CKD and greater rate of kidney function decline.
Meng Wang, W. Tang, Xinmin S. Li, Marcia C. de Oliveira Otto, Yujin Lee, R. Lemaitre, A. Fretts, Ina Nemet, N. Sotoodehnia, C. Sitlani, Matthew J. Budoff, J. DiDonato, Zeneng Wang, N. Bansal, M. Shlipak, B. Psaty, D. Siscovick, M. Sarnak, D. Mozaffarian, Stanley L. Hazen   +19 more
semanticscholar   +1 more source

Microbial Dimethylsulfoxide and Trimethylamine-N-Oxide Respiration

2005
Over the last two decades, the biochemistry and genetics of dimethylsulfoxide (DMSO) and trimethylamine-N-oxide (TMAO) respiration has been characterised, particularly in Escherichia coli marine bacteria of the genus Shewanella and the purple phototrophic bacteria, Rhodobacter sphaeroides and R. capsulatus.
McCrindle, S. L., Kappler, U., McEwan, A. G.   +2 more
openaire   +3 more sources

Thermal conversion of trimethylamine-N-oxide to trimethylamine and dimethylamine in squids

Food and Chemical Toxicology, 1985
The levels of dimethylamine-nitrogen (DMA-N), trimethylamine-nitrogen (TMA-N) and trimethylamine-N-oxide-nitrogen (TMAO-N) were determined in five species of dried squid. Each sample contained extremely high levels of TMAO-N (2558-8064 ppm) and moderate amounts of TMA-N (121-503 ppm) and DMA-N (124-373 ppm). Over 90% of TMAO-N in squid was converted to
J K, Lin, D C, Hurng
openaire   +2 more sources

A comparative study of trimethylamine-N-oxide biosynthesis

Biochimica et Biophysica Acta, 1963
A broad spectrum of species of plants and animals have been examined for their ability to convert trimethylamine to its N-oxide. Of the animal species studied, and under the conditions used in this investigation, trimethylamine-N-oxide synthesis from trimethylamine seems generally to be restricted to the vertebrates.
J R, BAKER, A, STRUEMPLER, S, CHAYKIN
openaire   +2 more sources

Trimethylamine N-Oxide and Related Gut Microbe-Derived Metabolites and Incident Heart Failure Development in Community-Based Populations

Circulation: Heart Failure
BACKGROUND: Growing evidence indicates that trimethylamine N-oxide, a gut microbial metabolite of dietary choline and carnitine, promotes both cardiovascular disease and chronic kidney disease risk.
W. H. W. Tang, R. Lemaitre, P. Jensen, Meng Wang, Zeneng Wang, Xinmin S. Li, Ina Nemet, Yujin Lee, Heidi T M Lai, Marcia C. de Oliveira Otto, A. Fretts, N. Sotoodehnia, J. DiDonato, Fredrik Bäckhed, B. Psaty, D. Siscovick, Matthew J. Budoff, D. Mozaffarian, Stanley L. Hazen   +18 more
semanticscholar   +1 more source

Trimethylamine N-Oxide (TMAO) as a Biomarker

2022
The interaction between diet, microbiome, and noncommunicable disease onset is gaining growing attention. The trimethylamine N-oxide (TMAO) is a gut microbiota derivative that has been suggested as a potential regulator of human health, especially (but not exclusively) for its association with cardiovascular diseases. It derives from the trimethylamine
Gabbianelli, Rosita, Bordoni, Laura
openaire   +3 more sources

การตรวจ trimethylamine n-oxide (TMAO) ในซีรัมเพื่อทำนายภาวะหลอดเลือดแข็งตัวในผู้ป่วยโรคไตเรื้อรัง

2023
ความเป็นมา: การเพิ่มขึ้นของสาร trimethylamine N-oxide (TMAO) ซึ่งเป็นสารพิษที่มาจากแบคทีเรียในลำไส้ของผู้ป่วยโรคไตเรื้อรัง (chronic kidney disease; CKD) อาจช่วยเพิ่มการผลิต TMAO reductase ซึ่งเป็นเอนไซม์ของแบคทีเรียในลำไส้และมีการแทรกผ่านไปยังกระแสเลือดอันเนื่องมาจากข้อบกพร่องในการซึมผ่านของลำไส้ (gut leakage) และอาจนำมาใช้เป็นตัวบ่งชี้ภาวะหลอดเลือดแข ...
openaire   +1 more source

Trimethylamine-N-oxide

Current Opinion in Lipidology, 2016
This article evaluates the link between trimethylamine-N-oxide (TMAO) and bile acids and the consequent impact on the development of atherosclerosis.Elevation in plasma TMAO concentrations is associated with an increased risk of cardiovascular disease in many different patient cohorts.
Aze, Wilson, Cheynne, McLean, Richard B, Kim   +2 more
openaire   +2 more sources

Trimethylamine N-oxide impairs perfusion recovery after hindlimb ischemia

Biochemical and Biophysical Research Communications, 2020
The circulating level of trimethylamine N-oxide (TMAO) has been reported to be associated with the prognosis of of peripheral arterial disease (PAD) patients. However, the effects of TMAO on neovascularization and perfusion recovery after PAD are not known.Unilateral hindlimb ischemia was generated in mice as experimental PAD model, TMAO or 3,3 ...
Lingdan, Chen, Yinkang, Jin, Neng, Wang, Mingjie, Yuan, Tao, Lin, Wenju, Lu, Tao, Wang   +6 more
openaire   +2 more sources

Associations of serum trimethylamine N‐oxide and its precursors with colorectal cancer risk in the Prostate, Lung, Colorectal, Ovarian Cancer Screening Trial Cohort

Cancer
Dietary intake influences gut microbiome composition, which in turn may be associated with colorectal cancer (CRC). Associations of the gut microbiome with colorectal carcinogenesis may be mediated through bacterially regulated, metabolically active ...
Doratha A. Byrd, Semi Zouiouich, Smriti Karwa, Xinmin S. Li, Zeneng Wang, Joshua N. Sampson, E. Loftfield, Wenbin Huang, S. L. Hazen, Rashmi Sinha   +9 more
semanticscholar   +1 more source