Results 261 to 270 of about 551,207 (299)

Microbial Dimethylsulfoxide and Trimethylamine-N-Oxide Respiration

2005
Over the last two decades, the biochemistry and genetics of dimethylsulfoxide (DMSO) and trimethylamine-N-oxide (TMAO) respiration has been characterised, particularly in Escherichia coli marine bacteria of the genus Shewanella and the purple phototrophic bacteria, Rhodobacter sphaeroides and R. capsulatus.
McCrindle, S. L., Kappler, U., McEwan, A. G.   +2 more
openaire   +5 more sources

A comparative study of trimethylamine-N-oxide biosynthesis

Biochimica et Biophysica Acta, 1963
A broad spectrum of species of plants and animals have been examined for their ability to convert trimethylamine to its N-oxide. Of the animal species studied, and under the conditions used in this investigation, trimethylamine-N-oxide synthesis from trimethylamine seems generally to be restricted to the vertebrates.
J R, BAKER, A, STRUEMPLER, S, CHAYKIN
openaire   +2 more sources

The role of trimethylamine‐N‐Oxide in the development of Alzheimer's disease

Journal of Cellular Physiology, 2021
AbstractAlzheimer's disease is associated with multiple risk factors and is the most common type of dementia. Trimethylamine‐N‐oxide (TMAO), a gut microbiota metabolite derived from dietary choline and carnitine, has recently been identified as a potential risk factor of Alzheimer's disease.
Nida Buawangpong, Kanokporn Pinyopornpanish, Natthapat Siri‐Angkul, Nipon Chattipakorn, Siriporn C. Chattipakorn   +4 more
openaire   +2 more sources

Trimethylamine N-oxide synthesis: A human variant

Biochemical Medicine, 1972
Abstract A 6-year-old girl exhibiting a variety of clinical symptoms including an apparant inability to metabolize trimethylamine has been shown to possess a defective liver trimethylamine oxidizing system. The defect manifested itself in a Km for trimethylamine which was five times that characteristic of normal enzyme preparation.
T, Higgins, S, Chaykin, K B, Hammond, J R, Humbert   +3 more
openaire   +2 more sources

Tracing Immunological Interaction in Trimethylamine N‐Oxide Hydrogel‐Derived Zwitterionic Microenvironment During Promoted Diabetic Wound Regeneration

Advances in Materials
The diabetic wound healing is challenging due to the sabotaged delicate balance of immune regulation via an undetermined pathophysiological mechanism, so it is crucial to decipher multicellular signatures underlying diabetic wound healing and seek ...
Zheng Li, Longwei Li, Muxin Yue, Qingyu Peng, Xiong Pu, Yongsheng Zhou   +5 more
semanticscholar   +1 more source

The Gut Microbial Metabolite Trimethylamine N-oxide, Incident CKD, and Kidney Function Decline

Journal of the American Society of Nephrology
Visual Abstract Key Points In community-based US adults, higher plasma trimethylamine N-oxide levels associated with higher risk of incident CKD and greater rate of kidney function decline.
Meng Wang, W. Tang, Xinmin S. Li, Marcia C. de Oliveira Otto, Yujin Lee, R. Lemaitre, A. Fretts, Ina Nemet, N. Sotoodehnia, C. Sitlani, M. Budoff, J. DiDonato, Zeneng Wang, N. Bansal, M. Shlipak, B. Psaty, D. Siscovick, M. Sarnak, D. Mozaffarian, Stanley L. Hazen   +19 more
semanticscholar   +1 more source

A Genetic polymorphism of the N-oxidation of trimethylamine in humans

Clinical Pharmacology and Therapeutics, 1987
Trimethylamine (TMA) and its N-oxide (TMAO) are normal components of human urine. They are present in the diet and also derived from the enterobacterial metabolism of precursors such as choline. Dietary TMA is almost entirely metabolized to and excreted as TMAO.
M, Al-Waiz, R, Ayesh, S C, Mitchell, J R, Idle, R L, Smith   +4 more
openaire   +2 more sources

Trimethylamine N-Oxide and Related Gut Microbe-Derived Metabolites and Incident Heart Failure Development in Community Based Populations

Circulation: Heart Failure
BACKGROUND: Growing evidence indicates that trimethylamine N-oxide, a gut microbial metabolite of dietary choline and carnitine, promotes both cardiovascular disease and chronic kidney disease risk.
W. Tang, R. Lemaitre, P. Jensen, Meng Wang, Zeneng Wang, Xinmin S. Li, Ina Nemet, Yujin Lee, Heidi T M Lai, Marcia C. de Oliveira Otto, A. Fretts, N. Sotoodehnia, J. DiDonato, Fredrik Bäckhed, B. Psaty, D. Siscovick, M. Budoff, D. Mozaffarian, Stanley L. Hazen   +18 more
semanticscholar   +1 more source

The effect of trimethylamine N-oxide on RNase a stability

Journal of Thermal Analysis and Calorimetry, 2007
The thermal stability of bovine pancreatic ribonuclease (RNase A) has been investigated in the presence of trimethylamine N-oxide (TMAO), a naturally occurring osmolyte, by means of differential scanning calorimetry (DSC) and circular dichroism (CD) measurements at neutral and acid pH conditions.
F. FOGLIA, CARULLO, PAOLA, DEL VECCHIO, POMPEA GIUSEPPINA GRAZIA   +2 more
openaire   +4 more sources

Trimethylamine N-oxidation in Turkish women with bacterial vaginosis

Pharmacogenetics, 1996
Bacterial vaginosis (BV) is the most common cause of vaginal discharge in women of child-bearing age. A common symptom of this condition is a fishy-smelling vaginal discharge. Trimethylamine (TMA) is the substance which is primarily responsible for this distinctive odour.
Green, RL, Mellon, T, Akyol, D, Sardas, S, Cholerton, S, Gokmen, O   +5 more
openaire   +3 more sources