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The role of trimethylamine N-oxide in disease pathogenesis and the therapeutic potential of traditional Chinese medicine. [PDF]

Front Pharmacol
Qin Z, Wu W, Yang X, Wang X, Ding A, Huang Y, Tang J, Jiang S, Zhang P, Qian C, Zhang X, Zhou S, Wang Y, Song Z, Sun M, Wang M, Shen S, Zhu B.   +17 more
europepmc   +1 more source

Trimethylamine N-Oxide (TMAO) as a Biomarker

, 2022
The interaction between diet, microbiome, and noncommunicable disease onset is gaining growing attention. The trimethylamine N-oxide (TMAO) is a gut microbiota derivative that has been suggested as a potential regulator of human health, especially (but not exclusively) for its association with cardiovascular diseases. It derives from the trimethylamine
Gabbianelli, Rosita, Bordoni, Laura
core   +4 more sources

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Trimethylamine N-Oxide in Aquatic Foods.

Journal of Agricultural and Food Chemistry
Trimethylamine N-oxide (TMAO), a characteristic nonprotein nitrogen compound, is widely present in seafood, which exhibits osmoregulatory effects for marine organisms in vivo and plays an important role in aquaculture and aquatic product preservation ...
Xiaoyue Li, Cheng-Cheng Wang, Teruyoshi Yanagita, Changhu Xue, Tiantian Zhang, Yuming Wang   +5 more
semanticscholar   +3 more sources

Trimethylamine N-Oxide (TMAO), Diet and Cardiovascular Disease

Current Atherosclerosis Reports, 2021
The association between plasma Trimethylamine N-Oxide (TMAO), diet and risk for cardiovascular disease (CVD) is still not fully understood. While epidemiologic research shows a causal relationship between plasma TMAO concentrations and CVD risk, the role of dietary precursors in determining plasma concentrations of TMAO and biomarkers for CVD is ...
M. Thomas, M. Fernández
semanticscholar   +3 more sources

Trimethylamine/Trimethylamine-N-Oxide as a Key Between Diet and Cardiovascular Diseases

Cardiovascular Toxicology, 2021
Trimethylamine (TMA) is a gut microbiota-derived metabolite which comes from diets rich of choline, betaine or L-carnitine and could be further converted to Trimethylamine-N-oxide (TMAO) in the liver. As the function of gut microbiota and its metabolites being explored so far, studies suggest that TMAO may be a potential risk factor of cardiovascular ...
Siyu He, Hong Jiang, Caili Zhuo, Wei Jiang   +3 more
openaire   +2 more sources

Genetic polymorphism of trimethylamine N-oxidation

Pharmacology & Therapeutics, 1990
Example of a food idiosyncracy, known to represent a pharmacogenetic polymorphism: trimethylaminuria of «fish-odour syndrome». Primary trimethylaminuria must be distinguished from the trimethylaminurias which are non-genetic in origin and which are secondary to other factors such as renal or hepatic disease or overload with trimethylamine ...
R, Ayesh, R L, Smith
openaire   +2 more sources

Trimethylamine-N-oxide Biosynthesis in the Bullfrog

Nature, 1966
THE comparative aspects of the mechanism of oxygenations dependent on molecular oxygen have recently been investigated using the biosynthesis of trimethylamine-N-oxide as a model1. That investigation raised a number of questions beyond the presence of the enzymatic activity in a given organism.
K, Murray, K, Chakraverty, S, Chaykin
openaire   +2 more sources

Thermal conversion of trimethylamine-N-oxide to trimethylamine and dimethylamine in squids

Food and Chemical Toxicology, 1985
The levels of dimethylamine-nitrogen (DMA-N), trimethylamine-nitrogen (TMA-N) and trimethylamine-N-oxide-nitrogen (TMAO-N) were determined in five species of dried squid. Each sample contained extremely high levels of TMAO-N (2558-8064 ppm) and moderate amounts of TMA-N (121-503 ppm) and DMA-N (124-373 ppm). Over 90% of TMAO-N in squid was converted to
J K, Lin, D C, Hurng
openaire   +2 more sources