Synthesis, Chemistry, Biological Evaluation And Structure-Activity Relationships Of Rac- And Chiral 6-Desmethyl-5Β –Hydroxy-D-Secoartemisinin And Analogs [PDF]
, 2017 The prevention and cure of malaria is difficult as it thrives under poor socio- and pharmacoeconomic conditions in third world, tropical and subtropical regions. It is a parasitic disease spread through the bite of an infected Anopheles mosquito.
Jihan, Mohamed Elsideiq
core +1 more source
Dispiro-1,2,4-trioxane Analogues of a Prototype Dispiro-1,2,4-trioxolane: Mechanistic Comparators for Artemisinin in the Context of Reaction Pathways with Iron(II) [PDF]
, 2005 Single electron reduction of the 1,2,4-trioxane heterocycle of artemisinin (1) forms primary and secondary carbon-centered radicals. The complex structure of 1 does not lend itself to a satisfactory dissection of the electronic and steric effects that ...
Dong, Yuxiang +5 more
core +1 more source
Drug Development Strategies for Malaria: With the Hope for New Antimalarial Drug Discovery-An Update. [PDF]
Adv Med, 2023 Pandey SK +3 more
europepmc +1 more source
Polymerization of Trioxane with Tetrabromomethane
The Journal of the Society of Chemical Industry, Japan, 1966 トリオキサンにテトラブロムメタンをトリオキサンに対して0.001～1.0%添加し,蒸留するか,または加熱溶融するとトリオキサン重合物を得る。種々の条件で重合を試みた結果,トリオキサンに0.2wt%のテトラブロムメタンを混合し,85℃に10分間,ついで50℃で6時間加熱重合させると62%の収率で[η]1.5の重合物を得ることができた。また,この重合反応は,常に臭化水素の発生を伴い,窒素気流中,あるいはトルエン,水の添加で反応を行なうと重合は起こらず,同時に臭化水素の発生もなくなる。水素化カルシウム,炭酸カルシウムを添加して,この反応を行なうと,臭化水素は臭化カルシウムとなり,重合は起こらない。その他の多くの実験事実から,本重合はトリオキサンを空気中でテトラブロムメタンと加熱すると ...
Saburo INOKAWA +4 more
openaire +2 more sources
Design, molecular docking, drug-likeness, and molecular dynamics studies of 1,2,4-trioxane derivatives as novel Plasmodium falciparum falcipain-2 (FP-2) inhibitors. [PDF]
BioTechnologia (Pozn), 2021 Ghosh S, Chetia D, Gogoi N, Rudrapal M.
europepmc +1 more source
Dispiro- 1,2,4,5-tetraoxanes: A New Class of Antimalarial Peroxides [PDF]
, 1992 Dispiro-l,2,4,5tetraoxanes2 -4 were synthesized as potential peroxide a n t h a l a* d drugs. They had curative activity against Plasmodium berghei in vivo at single doses of 320 and 640 mg/kg which confirms earlier unpublished data Moreover, artemisinin
Ager, Arba L., Jr. +7 more
core +1 more source
Lipid Targets of the Antimalarial Trioxanes in \u3ci\u3ePlasmodium falciparum\u3c/i\u3e [PDF]
, 2009 Malaria is among the most debilitating diseases of man. The protozoan parasite, Plasmodium falciparum, causes over a million annual fatalities. The antimalarial trioxanes, exemplified by artemisinin, are among the few pharmaceuticals for which clinical ...
Hartwig, Carmony Leah
core +1 more source
Effects of Albumin-Chlorogenic Acid Nanoparticles on Apoptosis and PI3K/Akt/mTOR Pathway Inhibitory Activity in MDA-MB-435s Cells. [PDF]
Nanomaterials (Basel), 2023 Alzahrani B +9 more
europepmc +1 more source
Application of BF3·Et2O in the synthesis of cyclic organic peroxides (microreview). [PDF]
Chem Heterocycl Compd (N Y), 2020 Radulov PS, Yaremenko IA.
europepmc +1 more source