Solvent and Substituent Effects on the Kinetics of Thermolysis of cis-Fused 1,2,4-Trioxanes [PDF]
Molecules, 2001 The kinetics of the thermal decomposition reaction of cis-6-phenyl-5,6-(2-phenylpropyliden)-3,3-pentamethylene-1,2,4-trioxacyclohexane (Ia) were investigated in benzene and methanol solutions in the temperature and concentration ranges of 353.3 †...
Charles W. Jefford +1 more
doaj +8 more sources
Synthesis of spiroannulated and 3-arylated 1,2,4-trioxanes from mesitylol and methyl 4-hydroxytiglate by photooxygenation and peroxyacetalization [PDF]
Beilstein Journal of Organic Chemistry, 2010 Cycloalkanones were utilized in the Lewis acid catalyzed peroxyacetalization of ß-hydroperoxy homoallylic alcohols (prepared by the ene reaction of the allylic alcohols mesitylol and methyl 4-hydroxytiglate, respectively, with singlet oxygen) to give ...
Axel G Griesbeck
exaly +3 more sources
Synthesis, Structure and Antileishmanial Evaluation of Endoperoxide–Pyrazole Hybrids [PDF]
Molecules, 2022 Leishmaniases are among the most impacting neglected tropical diseases. In attempts to repurpose antimalarial drugs or candidates, it was found that selected 1,2,4-trioxanes, 1,2,4,5-tetraoxanes, and pyrazole-containing chemotypes demonstrated activity ...
Patrícia S. M. Amado +5 more
doaj +7 more sources
Biological Evaluation in Resistant Cancer Cells and Study of Mechanism of Action of Arylvinyl-1,2,4-Trioxanes [PDF]
Pharmaceuticals, 2022 1,2,4-trioxane is a pharmacophore, which possesses a wide spectrum of biological activities, including anticancer effects. In this study, the cytotoxic effect and anticancer mechanism of action of a set of 10 selected peroxides were investigated on five ...
Jerome P. L. Ng +10 more
doaj +2 more sources
Photo-oxygenation of Indene and 1,2-Dihydronaphthalene: Formation of 1,2-Dioxetanes and 1,2,4-Trioxanes [PDF]
CHIMIA, 1992 The methylene blue (MB)-sensitized photo-oxygenation of indene (1) in CH3OH gave trans-2-hydroperoxy-1-methoxyindane (9), homophthalaldehyde (4), and its cyclic acetal 8. The same reaction conducted in acetaldehyde gave only 4.
Charles W. Jefford +3 more
doaj +5 more sources
Lewis Acids and Heteropoly Acids in the Synthesis of Organic Peroxides. [PDF]
Pharmaceuticals (Basel), 2022 Organic peroxides are an important class of compounds for organic synthesis, pharmacological chemistry, materials science, and the polymer industry. Here, for the first time, we summarize the main achievements in the synthesis of organic peroxides by the
Yaremenko IA +5 more
europepmc +3 more sources
Artemisinins and synthetic peroxides as highly efficient antimalarials [PDF]
Macedonian Journal of Chemistry and Chemical Engineering, 2012 Malaria is devastating disease and global public health problem, with nearly half world population exposed to risk. Illness is caused by five Plasmodium species, P. falciparum, P. ovale, P. vivax, P. malarie and P. knowlesi, from which P.
Dejan Milos Opsenica +1 more
doaj +6 more sources
1,2,5,10,11,14-Hexaoxadispiro[5.2.5.2]hexadecanes: Novel Spirofused Bis-Trioxane Peroxides [PDF]
Molecules, 2008 A set of new bis-spirofused 1,2,4-trioxanes 4a-d was obtained from the reaction of cyclohexane-1,4-dione with allylic hydroperoxides 2a-d, bearing an additional hydroxy group in the homoallylic position, by diastereoselective photooxygenation of allylic ...
Tamer T. El-Idreesy +5 more
doaj +2 more sources
Synthesis of five- and six-membered cyclic organic peroxides: Key transformations into peroxide ring-retaining products [PDF]
Beilstein Journal of Organic Chemistry, 2014 The present review describes the current status of synthetic five and six-membered cyclic peroxides such as 1,2-dioxolanes, 1,2,4-trioxolanes (ozonides), 1,2-dioxanes, 1,2-dioxenes, 1,2,4-trioxanes, and 1,2,4,5-tetraoxanes.
Alexander O. Terent'ev +3 more
doaj +2 more sources
Solvent and Substituent Effects on the Thermolysis of Antimalarial Fluorophenyl Substituted 1,2.4-Trioxanes [PDF]
Molecules, 2003 The kinetics and mechanism of the thermal decomposition reaction of cis-6-(4-fluoropheny1)-5,6-[2-(4-fluorophenyl)-propylidene]-3, 3-tetramethylene-1,2,4-trioxacyclo-hexane (I) were investigated separately in n-hexane and in methanol solutions over the ...
Cafferata, Lázaro F. R. +1 more
europepmc +9 more sources