Sesquiterpene Lactones from Artemisia Genus: Biological Activities and Methods of Analysis
Journal of Analytical Methods in Chemistry, Volume 2015, Issue 1, 2015., 2015 Sesquiterpene lactones are a large group of natural compounds, found primarily in plants of Asteraceae family, with over 5000 structures reported to date. Within this family, genus Artemisia is very well represented, having approximately 500 species characterized by the presence of eudesmanolides and guaianolides, especially highly oxygenated ones, and
Bianca Ivanescu +3 more
wiley +1 more source
Malaria Research and Treatment, Volume 2014, Issue 1, 2014., 2014 Background. CDRI 97/78 has shown efficacy in animal models of falciparum malaria. The present study is the first in‐human phase I trial in healthy volunteers. Methods. The study was conducted in 50 healthy volunteers in a single, ascending dose, randomized, placebo‐controlled, double blind design.
N. Shafiq +15 more
wiley +1 more source
Photooxygenation of Allylic Alcohols in Polymer Matrices . Synthesis of New Antimalarial Peroxides [PDF]
, 2005 The photooxygenation of organic substrates in polymer matrix as reaction medium using a solvent-free approach was investigated. Two microreactor systems were used: (1) commercially available polystyrene beads crosslinked with divinylbenzene and loaded ...
El-Idreesy, Tamer Tawhid
core
Studies of the thermal rearrangements of dispiro-1,2,4-Trioxanes [PDF]
, 2009 A series of α-alkoxy-3,6-dispiro-1,2,4-trioxanes have been synthesised by acid-catalysed perhydrolyses of α-alkoxy methylenecyclohexane oxides (provides ring A) to give selectively the corresponding 1-hydroperoxy-1-(hydroxymethyl)cyclohexanes followed
Taylor, Benjamin J.
core +1 more source
Anti-giardia activity of hexane extract of Citrus aurantifolia (Christim) swingle and some of its constituents [PDF]
, 2015 Background: Giardia lamblia is a parasite that causes giardiasis in humans and other mammals. The common treatment includes different drugs, which were described to produce unpleasant side effects.
Camacho-Corona, MdR +6 more
core +2 more sources
The anti-tumour activity and mode of action of artesunate and dihydroartemisinin (alone and in combination with aspirin) against human leukaemia HL-60 and colorectal HT-29-AK cancer cells [PDF]
, 2016 Despite the considerable progress in cancer research which has been translated into better cancer care and decreased overall mortality rates in the last decade for numerous cancers, colorectal carcinoma (CRC) and leukaemia remain still one of the ...
Maryniak, Lidia Barbara
core +1 more source
Estudio de la descomposición térmica de cis-6-fenil-5,6-(2-fenilpropiliden)-3,3-tetrametilen-1,2,4-trioxaciclohexano en solución [PDF]
, 2010 En los últimos años diferentes autores han orientado sus investigaciones a la síntesis de compuestos útiles en el tratamiento farmacológico de la enfermedad malaria.
Mateo, Carmen Margarita
core +1 more source
The cyclisation of unsaturated peroxides [PDF]
, 1992 The reactions of several γ,δ-unsaturated hydroperoxides with tert-butyl hypochlorite have been investigated, and it has been shown that this provides a general synthesis of 3-(1-chloroalkyl)-1,2-dioxolanes.
Tallant, Neil Antony
core
Dispiro- 1,2,4,5-tetraoxanes: A New Class of Antimalarial Peroxides [PDF]
, 1992 Dispiro-l,2,4,5tetraoxanes2 -4 were synthesized as potential peroxide a n t h a l a* d drugs. They had curative activity against Plasmodium berghei in vivo at single doses of 320 and 640 mg/kg which confirms earlier unpublished data Moreover, artemisinin
Ager, Arba L., Jr. +7 more
core +1 more source
Activity of pentamidine and pentamidine analogs against Toxoplasma gondii in cell cultures. [PDF]
, 1991 The capabilities of pentamidine and nine pentamidine analogs to inhibit the development of Toxoplasma gondii were examined in vitro. Treatment of infected cultures with pentamidine and five of its analogs caused a significant (P less than 0.05) reduction
Lindsay, D S +3 more
core +3 more sources