Results 51 to 60 of about 669 (167)

Synthesis, Chemistry, Biological Evaluation And Structure-Activity Relationships Of Rac- And Chiral 6-Desmethyl-5Β –Hydroxy-D-Secoartemisinin And Analogs [PDF]

, 2017
The prevention and cure of malaria is difficult as it thrives under poor socio- and pharmacoeconomic conditions in third world, tropical and subtropical regions. It is a parasitic disease spread through the bite of an infected Anopheles mosquito.
Jihan, Mohamed Elsideiq
core   +1 more source

Structural characterization of strained oxacycles by 13C NMR spectroscopy [PDF]

, 2011
The 1H and 13C NMR data of a series of epoxy-and epidioxy-bridged tetrahydropyran derivatives containing the same basic carbon skeleton, are reported. 13C NMR spectroscopy was shown to be useful for structural determination of both substructures allowing
la Venia, Agustina, Mischne, Mirta Paulina, Riveira, Martín Jorge   +2 more
core   +1 more source

Mechanistic Evaluation of the Stability of Arylvinyl-1,2,4-trioxanes under Acidic Conditions for Their Oral Administration as an Antimalarial Drug. [PDF]

ACS Omega, 2022
Kumari A, Karnatak M, Singh AS, Hassam M, Rawat V, Islam MS, Al-Majid AM, Singh M, Verma VP.   +8 more
europepmc   +1 more source

Methyl-Substituted Dispiro-1,2,4,5-tetraoxanes:  Correlations of Structural Studies with Antimalarial Activity [PDF]

, 2000
Two tetramethyl-substituted dispiro-1,2,4,5-tetraoxanes (7,8,15,16-tetraoxadispiro[5.2.5.2]- hexadecanes) 3 and 4 were designed as metabolically stable analogues of the dimethylsubstituted dispiro-1,2,4,5-tetraoxane prototype WR 148999 (2).
Dong, Yuxiang, McCollough, Kevin J., Vennerstrom, Jonathan L., Walter Reed Army Institute of Research, Walter Reed Army Institute of Research, Walter Reed Army Institute of Research, Wood, James K.   +6 more
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Dispiro-1,2,4-trioxane Analogues of a Prototype Dispiro-1,2,4-trioxolane: Mechanistic Comparators for Artemisinin in the Context of Reaction Pathways with Iron(II) [PDF]

, 2005
Single electron reduction of the 1,2,4-trioxane heterocycle of artemisinin (1) forms primary and secondary carbon-centered radicals. The complex structure of 1 does not lend itself to a satisfactory dissection of the electronic and steric effects that ...
Dong, Yuxiang, Sriraghavan, Kamaraj, Tang, Yuanqing, Vennerstrom, Jonathan L., Wang, Xiaofang, Wood, James K.   +5 more
core   +1 more source

Advances in the synthesis of acyclic peroxides [PDF]

, 2017
Peroxide-containing compounds are an attractive synthetic target, given their widespread abundance in nature, with many displaying potent antimalarial and antimicrobial properties.
Gandhi, Hirenkumar, Gupta, Manoj K., Horgan, Conor C., O'Leary, Eileen M., O'Reilly, Kate, O'Sullivan, Timothy P.   +5 more
core   +2 more sources

Design, molecular docking, drug-likeness, and molecular dynamics studies of 1,2,4-trioxane derivatives as novel Plasmodium falciparum falcipain-2 (FP-2) inhibitors. [PDF]

BioTechnologia (Pozn), 2021
Ghosh S, Chetia D, Gogoi N, Rudrapal M.
europepmc   +1 more source

Singulett-Sauerstoff Reaktionen zur Synthese von neuen biologisch aktiven 1,2,4-Trioxansäuren, -amiden und -estern und weiteren cyclischen Peroxiden sowie von Photocage-Verbindungen [PDF]

, 2013
Zehn neue 1,2,4-Trioxansäuren , -amide und -ester wurden ausgehend von 4-Hydroxytiglinsäure synthetisiert. Deren Herstellung beinhaltet eine Umsetzung der 4-Hydroxytiglinsäure und deren Derivate mit Singulett-Sauerstoff zu 1,2-Hydroxyhydroperoxiden und ...
Schlundt, Viktor
core  

Research News. Publications, 2020. Volume 3 [PDF]

, 2020
Publications that appeared during the period July 1 through September 30 ...
Majumdar, Soumyajit
core   +3 more sources

Application of BF₃·Et₂O in the synthesis of cyclic organic peroxides (microreview). [PDF]

Chem Heterocycl Compd (N Y), 2020
Radulov PS, Yaremenko IA.
europepmc   +1 more source