Results 21 to 30 of about 669 (167)
The newly discovered role of endocytosis in artemisinin resistance
Medicinal Research Reviews, Volume 41, Issue 6, Page 2998-3022, November 2021., 2021 Abstract Artemisinin and its derivatives (ART) are the cornerstone of malaria treatment as part of artemisinin combination therapy (ACT). However, reduced susceptibility to artemisinin as well as its partner drugs threatens the usefulness of ACTs. Single point mutations in the parasite protein Kelch13 (K13) are necessary and sufficient for the reduced ...
Hannah Michaela Behrens +2 more
wiley +1 more source
European Journal of Organic Chemistry, Volume 2021, Issue 21, Page 2923-2939, June 7, 2021., 2021 Organocatalytic desymmetrization reactions are powerful methodologies for the generation of molecular complexity and the creation of multiple stereocenters in a single operation. The use of intramolecular (hetero)‐Michael reactions in desymmetrization processes using carbon‐, oxygen‐, and nitrogen‐centered nucleophiles allowed for the creation of ...
Marcos Escolano +4 more
wiley +1 more source
Malaria Pigment Crystals: The Achilles′ Heel of the Malaria Parasite
ChemMedChem, Volume 16, Issue 10, Page 1515-1532, May 18, 2021., 2021 The crystallization of hemozoin, the malaria pigment, within infected red blood cells is the Achilles′ heel of malaria‐causing Plasmodium parasites. Being a vital parasitic waste‐disposal mechanism, hemozoin crystallization is an attractive antimalarial drug target.
Sergey Kapishnikov +4 more
wiley +1 more source
Antitumor Activity of Artemisinin and Its Derivatives: From a Well-Known Antimalarial Agent to a Potential Anticancer Drug [PDF]
, 2011 Improvement of quality of life and survival of cancer patients will be greatly enhanced by the development of highly effective drugs to selectively kill malignant cells.
P. Crespo-Ortiz, Maria, Wei, Ming
core +2 more sources
CHIMIA, 2009 A concise biography of C. W. Jefford, Professor of Chemistry in Geneva from 1969 to 1994, is given. A personal tribute by the author is paid to Jefford ' s fundamental work in the field of singlet oxygen, endo-peroxides, and 1,2,4-trioxanes as ...
Ulrich Burger
doaj +1 more source
Angewandte Chemie, Volume 131, Issue 37, Page 13200-13213, September 9, 2019., 2019 Hybride auf Artemisinin‐Basis, die wirksam gegen CQ‐ und multiresistente Parasiten sind und eine starke Wirksamkeit bei experimenteller Malaria aufweisen, wurden synthetisiert. Durch chemische Proteomik wurden neue, möglicherweise hybridbindende Proteine zusätzlich zu den bekannten Zielproteinen von Chinolin und Artemisinin identifiziert, was darauf ...
Aysun Çapcı +15 more
wiley +2 more sources
Novel series of 1,2,4-trioxane derivatives as antimalarial agents [PDF]
Journal of Enzyme Inhibition and Medicinal Chemistry, 2017 Among three series of 1,2,4-trioxane derivatives, five compounds showed good in vitro antimalarial activity, three compounds of which exhibited better activity against P. falciparum resistant (RKL9) strain than the sensitive (3D7) one. Two best compounds were one from aryl series and the other from heteroaryl series with IC50 values of 1.24 µM and 1.24
Mithun Rudrapal +2 more
openaire +3 more sources
6-(7-Nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol, a specific glutathione S-transferase inhibitor, overcomes the multidrug resistance (MDR)-associated protein 1-mediated MDR in small cell lung cancer [PDF]
, 2008 In the present work, we have investigated the antitumor activity of 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol (NBDHEX) on aggressive small cell lung cancer. NBDHEX not only is cytotoxic toward the parental small cell lung cancer H69 cell line (LC50
Caccuri, AM +8 more
core +1 more source
, 2009 The problem of endemic malaria continues unabated globally. Malaria affects 40 % of the global population, causing an estimated annual mortality of 1.5-2.7 million people.
Opsenica, Dejan M., Šolaja, Bogdan A.
core +4 more sources
Anticancer activity of the iron facilitator LS081 [PDF]
, 2011 Background Cancer cells have increased levels of transferrin receptor and lower levels of ferritin, an iron deficient phenotype that has led to the use of iron chelators to further deplete cells of iron and limit cancer cell growth.
Zhen Li +3 more
core +2 more sources