Results 11 to 20 of about 669 (167)
Pharmacokinetic study and bioavailability of a novel synthetic trioxane antimalarial compound 97/63 in rats. [PDF]
Malar Res Treat, 2014 Single dose pharmacokinetics study of 97/63 (IND191710, 2004), a trioxane antimalarial developed by Central Drug Research Institute, Lucknow, India, was studied in rats following intravenous and oral administration. Serum samples were analysed by HPLC-UV
Kushwaha HN +3 more
europepmc +6 more sources
1,2,4-Trioxolane and 1,2,4,5-Tetraoxane Endoperoxides against Old-World Leishmania Parasites: In Vitro Activity and Mode of Action. [PDF]
Pharmaceuticals (Basel), 2022 Leishmaniasis remains one of the ten Neglected Tropical Diseases with significant morbidity and mortality in humans. Current treatment of visceral leishmaniasis is difficult due to a lack of effective, non-toxic, and non-extensive medications. This study
Mendes A +6 more
europepmc +3 more sources
Reduction of the Double Bond of 6‑Arylvinyl-1,2,4-trioxanes Leads to a Remarkable Increase in Their Antimalarial Activity against Multidrug-Resistant Plasmodium yoelii nigeriensis in a Swiss Mice Model [PDF]
ACS Omega, 2021 Mohammad Hassam +5 more
doaj +2 more sources
Drug Development Strategies for Malaria: With the Hope for New Antimalarial Drug Discovery-An Update. [PDF]
Adv Med, 2023 Malaria continued to be a deadly situation for the people of tropical and subtropical countries. Although there has been a marked reduction in new cases as well as mortality and morbidity rates in the last two decades, the reporting of malaria caused 247 million cases and 619000 deaths worldwide in 2021, according to the WHO (2022).
Pandey SK +3 more
europepmc +2 more sources
The Impact of Activity-Based Protein Profiling in Malaria Drug Discovery. [PDF]
ChemMedChem, 2022 Activity‐based protein profiling has impacted several biological research areas by providing functional fingerprints of enzymatic activity in complex proteomes. We discuss the main achievements of ABPP in the field of malaria research, including characterization of pathologically‐relevant enzymes, target and mechanism deconvolution of antimalarials ...
Carvalho LAR, Bernardes GJL.
europepmc +2 more sources
Asymmetric Organocatalyzed Intermolecular Functionalization of Cyclohexanone‐Derived Dienones
The Chemical Record, Volume 23, Issue 7, July 2023., 2023 Asymmetric organocatalysis plays a key role in organic synthesis and this review describes the use of this tool for the functionalization of cyclohexanone‐derived dienones. By using diverse organocatalysts, enantioenriched functionalized cyclohexanone derivatives were obtained through covalent and non‐covalent asymmetric organocatalysis.
Corinne Coutant +3 more
wiley +1 more source
Medicinal Research Reviews, Volume 43, Issue 3, Page 614-682, May 2023., 2023 Abstract Ferroptosis is an iron‐dependent cell death program that is characterized by excessive lipid peroxidation. Triggering ferroptosis has been proposed as a promising strategy to fight cancer and overcome drug resistance in antitumor therapy. Understanding the molecular interactions and structural features of ferroptosis‐inducing compounds might ...
Solveigh C. Koeberle +3 more
wiley +1 more source
Oxidative Medicine and Cellular Longevity, Volume 2022, Issue 1, 2022., 2022 Aging is associated with the occurrence of diverse degenerative changes in various tissues and organs and with an increased incidence of neurological disorders, especially neurodegenerative diseases such as Alzheimer’s disease (AD). In recent years, the search for effective components derived from medicinal plants in delaying aging and preventing and ...
Qin Li +7 more
wiley +1 more source
Artemisia spp.: An Update on Its Chemical Composition, Pharmacological and Toxicological Profiles
Oxidative Medicine and Cellular Longevity, Volume 2022, Issue 1, 2022., 2022 Artemisia plants are traditional and ethnopharmacologically used to treat several diseases and in addition in food, spices, and beverages. The genus is widely distributed in all continents except the Antarctica, and traditional medicine has been used as antimalarial, antioxidant, anticancer, antinociceptive, anti‐inflammatory, and antiviral agents ...
Javad Sharifi-Rad +17 more
wiley +1 more source
Artemisinin‐derived dimers from a chemical perspective
Medicinal Research Reviews, Volume 41, Issue 6, Page 2927-2970, November 2021., 2021 Abstract Considerable progress has been made with the rather recently developed dimer approach, which has already found applications in the development of new effective artemisinin‐derived antimalarial, anticancer, and antiviral agents. One observation common to these potential applications is the significant (i.e., much more than double) improvement ...
Aysun Çapcı +4 more
wiley +1 more source