Results 51 to 60 of about 56,477 (262)
Molecules, 2011 The aim of the study was to investigate the effect of Ginkgo biloba extract 50 (GBE50), a well-known natural antioxidant, against immunity and antioxidant enzyme activities in ischemia reperfusion (IR) rats. Rats were then divided into six groups fed for
Xia Guo, Pinting Zhao, Shaoping Lu
doaj +1 more source
Severe thrombocytopenia in a patient with inosine triphosphatase (ITPA)–CC genotype caused by pegylated interferon (IFN)-α-2a with ribavirin therapy: a case report [PDF]
, 2014 BACKGROUND: Pegylated interferon combined with ribavirin treatment is an effective therapy for chronic hepatitis C viral infection. However, pegylated interferon combined with ribavirin is associated with various adverse reactions.
Hiroyuki Kitagawa +4 more
core +1 more source
Ethanol Induced Disordering of Pancreatic Acinar Cell Endoplasmic Reticulum: An ER Stress/Defective Unfolded Protein Response Model. [PDF]
, 2018 Background & aimsHeavy alcohol drinking is associated with pancreatitis, whereas moderate intake lowers the risk. Mice fed ethanol long term show no pancreas damage unless adaptive/protective responses mediating proteostasis are disrupted. Pancreatic
Abrol, Ravinder +13 more
core +3 more sources
Journal of Intelligent Medicine, EarlyView.Abstract The isoproterenol‐induced myocardial infarction model is a well‐established experimental approach for studying cardiac injury and testing potential protective treatments. By overstimulating beta‐adrenergic receptors, this model closely reproduces key features of human heart attacks, including oxidative damage, calcium imbalance, inflammatory ...
Bushra Imran +5 more
wiley +1 more source
Rho GTPase signaling in rheumatic diseases
iScience, 2022 Summary: Rho guanosine triphosphatase (GTPases), as molecular switches, have been identified to be dysregulated and involved in the pathogenesis of various rheumatic diseases, mainly including rheumatoid arthritis, osteoarthritis, systemic sclerosis, and
Ruijie Zeng +4 more
doaj +1 more source
ADENOSINE TRIPHOSPHATASE IN THE MITOTIC APPARATUS [PDF]
Proceedings of the National Academy of Sciences, 1961 Methods.-Isolation of the mitotic apparatus: The principle of the new method has been described in several publications, and a detailed account of the procedure will appear shortly.5 Sea urchin eggs (Stronglycentrotus purpuratus) are the source of material, providing large quantities of cells in synchronous division.
D, MAZIA, R R, CHAFFEE, R M, IVERSON
openaire +2 more sources
LRRK2 as a Potential Disease‐Modifying Target in Sporadic Parkinson's Disease
Movement Disorders, EarlyView.Abstract A growing understanding of the role that leucine‐rich repeat kinase 2 (LRRK2) plays in Parkinson's disease (PD) supports continued focus on this enzyme as a therapeutic target for PD. Accumulating evidence suggests that there are phenotypic, neuropathologic, and biological similarities between sporadic PD (sPD) and familial forms in which ...
Anthony E. Lang +12 more
wiley +1 more source
Comprehensive characterization of donkey milk serum proteins
Journal of Future Foods, 2022 Donkey milk (DM) has attracted immense attention owing to its resemblance to human milk. Consequently, its components require rigorous analysis. This study aimed to identify DM serum proteins (DMSPs) using a label-free MS-based proteomics method. Herein,
Mohan Li +5 more
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Allosteric Regulation of RNA Affinity by Motif V‐VI Coupling in West Nile Virus NS3 Helicase
Proteins: Structure, Function, and Bioinformatics, EarlyView.ABSTRACT The rise of flaviviral diseases, including West Nile virus (WNV), presents a growing threat to global public health and underscores the urgent need for new therapeutic strategies. The non‐structural protein 3 helicase (NS3h) of the Orthoflavivirus genus, including WNV, is essential for viral replication and a promising antiviral target ...
Priti Roy, Martin McCullagh
wiley +1 more source
Small Methods, EarlyView.Cardenolide‐functionalized extracellular vesicles enable targeted delivery of the chemotherapeutic doxorubicin to A549 lung cancer cells by binding Na+/K+‐ATPase, which is overexpressed in these cells. Surface‐modified, drug‐loaded EVs exhibit enhanced cytotoxicity compared to unmodified EVs and free drug, suggesting this system may lower the effective
Maja Dorfner +7 more
wiley +1 more source