Results 131 to 140 of about 289,605 (341)

Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies.

Journal of Clinical Investigation, 2011
B. Lehmann, Joshua A. Bauer, X. Chen, M. Sanders, A. Chakravarthy, Y. Shyr, J. Pietenpol   +6 more
semanticscholar   +1 more source

Evaluating the Antiviral Efficacy of Encapsulated PKC Inhibitor BIM‐I against influenza A Virus Infection

Advanced Healthcare Materials, EarlyView.
This study explores nanoparticle delivery of the protein kinase C inhibitor bisindolylmaleimide‐I (BIM‐I) to combat influenza A virus infections. Encapsulation in biodegradable PLGA nanoparticles improved safety while maintaining the compound's strong antiviral activity.
Laura Klement, Jana Ismail, Josefine Schroeder, Amod Godbole, Johanna Schreiber, Christine Weber, Zoltan Cseresnyes, Marc T. Figge, Bettina Löffler, Ulrich S. Schubert, Stephanie Schubert, Christina Ehrhardt, Carsten Hoffmann   +12 more
wiley   +1 more source

Triple-Negative Breast Cancer: Clinical Features and Patterns of Recurrence

Clinical Cancer Research, 2007
R. Dent, M. Trudeau, K. Pritchard, W. Hanna, H. Kahn, C. Sawka, L. Lickley, E. Rawlinson, P. Sun, S. Narod   +9 more
semanticscholar   +1 more source

A Biomimetic Buffering Hydrogel Scaffold for Long‐Term Culture of Patient‐Derived Tumor Organoids

Advanced Healthcare Materials, EarlyView.
A biomimetic fibrous buffering hydrogel controls the local acidification at the tumoroid/hydrogel interface at the physiologically relevant level over 21‐day culture. The buffering effect promotes cancer cell proliferation in the tumoroids and supports the structural integrity and mechanical properties of the hydrogel scaffold over long‐term tumoroid ...
Elizaveta Gusarova, Fatemeh Ahmadi, Jennifer Cruickshank, Zheyuan Miao, David W. Cescon, Eugenia Kumacheva   +5 more
wiley   +1 more source

[Agkistrodon halys venom antitumor component-I inhibits vasculogenic mimicry in triple-negative breast cancer cells in vitro by down-regulating MMP2].

, 2022
Yubin Ge, Limin Lu, S Tian, Yi-Bin Xiao, Shangfu Xie, Q Wang, Honghai Zhi   +6 more
openalex   +2 more sources

Evaluation of the Dual Impact of Nanotechnologies on Health and Environment Through Alternative Bridging Models

Advanced Healthcare Materials, EarlyView.
This review explores how alternative invertebrate and small‐vertebrate models advance the evaluation of nanomaterials across medicine and environmental science. By bridging cellular and organismal levels, these models enable integrated assessment of toxicity, biodistribution, and therapeutic performance.
Marie Celine Lefevre, Margherita Bernardeschi, Matteo Battaglini, Gianni Ciofani   +3 more
wiley   +1 more source

Response to neoadjuvant therapy and long-term survival in patients with triple-negative breast cancer.

Journal of Clinical Oncology, 2008
C. Liedtke, C. Mazouni, K. Hess, F. André, A. Tordai, J. Mejia, W. Symmans, A. González-Angulo, B. Hennessy, Marjorie C. Green, M. Cristofanilli, G. Hortobagyi, L. Pusztai   +12 more
semanticscholar   +1 more source

Engineered Microfluidic Organoid Systems: New Paradigms for Menopause Mechanism Research and Personalized Medicine

Advanced Materials Technologies, EarlyView.
This review explores the integration of microfluidic technology with organoid systems as an innovative platform for studying menopausea complex multi‐organ condition. By enabling precise simulation of inter‐organ communication and hormone responses, microfluidic organoids offer a physiologically relevant model for investigating menopausal syndrome and ...
Qianyi Zhang, He Huang, Hongliang Dong, Qiang Ma, Hongyan Jin   +4 more
wiley   +1 more source

Advances in systemic therapies for triple negative breast cancer

British medical journal, 2023
R. Leon-Ferre, M. Goetz
semanticscholar   +1 more source

RETRACTION: The PI3K/mTOR Dual Inhibitor NVP‐BEZ235 Stimulates Mutant p53 Degradation to Exert Anti‐Tumor Effects on Triple‐Negative Breast Cancer Cells

FEBS Open Bio, EarlyView.
RETRACTION: J. Cai, J. Xia, J. Zou, Q. Wang, Q. Ma, R. Sun, H. Liao, L. Xu, D. Wang, and X. Guo, “The PI3K/mTOR Dual Inhibitor NVP‐BEZ235 Stimulates Mutant p53 Degradation to Exert Anti‐Tumor Effects on Triple‐Negative Breast Cancer Cells,” FEBS Open Bio 10, no. 4 (2020): 535–545, https://doi.org/10.1002/2211‐5463.12806.
wiley   +1 more source