Results 221 to 230 of about 289,605 (341)

Antiemesis Corticosteroids Potentiate Checkpoint Blockade Efficacy by Normalizing the Immune Microenvironment in Metastatic Murine Breast Cancer

Advanced Science, EarlyView.
Corticosteroids improve the efficacy of immune checkpoint blockade therapy in metastatic murine breast cancer. By normalizing the tumor immune microenvironment, corticosteroids reduce immunosuppressive signals, restore T‐cell function, and promote antitumor immune responses, resulting in enhanced tumor control.
John D. Martin, Koji Nagaoka, Myrofora Panagi, Akihiro Hosoi, Fotios Mpkeris, Pengwen Chen, Thahomina T. Khan, Margaret R. Martin, Changbo Sun, Chrysovalantis Voutouri, Maria Louca, Panagiotis Papageorgis, Akira Sumiyoshi, Nobuhiro Nitta, Kazuyoshi Takeda, Ichio Aoki, Kazunori Kataoka, Triantafyllos Stylianopoulos, Kazuhiro Kakimi, Horacio Cabral   +19 more
wiley   +1 more source

Targeting the UFL1-AKT cascade suppresses triple-negative breast cancer progression. [PDF]

Nat Commun
Yang X, Wen Y, Ma X, Qin S, Liu Y, Chen J, Zhang H, Goding CR, Cui R, Liu T.   +9 more
europepmc   +1 more source

A Structured Tumor-Immune Microenvironment in Triple Negative Breast Cancer Revealed by Multiplexed Ion Beam Imaging

Cell, 2018
Leeat Keren, M. Bosse, Diana Marquez, Roshan Angoshtari, Samir Jain, S. Varma, Soo-Ryum Yang, A. Kurian, D. V. Valen, Robert West, S. Bendall, Michael Angelo   +11 more
semanticscholar   +1 more source

A20 Facilitates Oxaliplatin Sensitivity in Colorectal Cancer Through Monoubiquitylation of IKK‐β

Advanced Science, EarlyView.
This study demonstrates that the expression of A20, a ubiquitin‐editing enzyme, is positively correlated with oxaliplatin sensitivity in colorectal cancer (CRC). Mechanistically, A20 enhances oxaliplatin sensitivity by inhibiting NF‐κB nuclear translocation through monoubiquitination of IKK‐β.
Fan Luo, Ting Yang, Jiaxin Cao, Qun Chen, Zhenhai Lu, Feiteng Lu, Chaozhuo Lin, Zengfei Xia, Yuanzhong Yang, Peng Li, Wenjuan Ma, Min Luo, Rongxin Zhang   +12 more
wiley   +1 more source

Prominent protumoral cellular compartments of the tumor microenvironment in triple-negative breast cancer. [PDF]

Front Cell Dev Biol
Sun S, Zhao P, Wang C, Du J, Zhang T, He X, Zuo Z, Li N, Zhou R.   +8 more
europepmc   +1 more source

31P Peripheral-blood Immune-predictors of pathological complete response in patients with triple-negative breast cancer undergoing neoadjuvant chemo-immunotherapy [PDF]

Celeste Santoro, Carmine Valenza, Gloria Pellizzari, Gabriele Antonarelli, Dario Trapani, Monica Milano, Elisabetta Munzone, Giuseppe Curigliano   +7 more
openalex   +1 more source

Logic‐Gated HSV‐TK/GCV Suicide Gene Circuit for Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
The BRAS comprises two modular genetic components driven by distinct tumor‐specific promoters and a failsafe layer with the NOT gate. This multi‐input logic gate circuit enables precise, specific expression of HSV‐TK in breast cancer cells with hardly expression in normal cell and effectively inhibits tumor growth in a triple‐negative breast cancer ...
Shasha Tang, Yuan Fang, Lingli Jin, Dongyang Liu, Yicheng Liu, Ruijia Zheng, Liyun Yong, Xin Wu, Longliang Qiao, Meiyan Wang, Fengfeng Cai   +10 more
wiley   +1 more source

Advances in Immunotherapy for HER2 Low-Expressing Triple-Negative Breast Cancer. [PDF]

Cancer Manag Res
Zhang X, Yang D, Lin X, Hu X, Li J, Deng S, Chen Q, Chen X.   +7 more
europepmc   +1 more source

Carboplatin in BRCA1/2-mutated and triple-negative breast cancer BRCAness subgroups: the TNT Trial

Nature Medicine, 2018
A. Tutt, H. Tovey, M. Cheang, S. Kernaghan, L. Kilburn, P. Gazinska, J. Owen, J. Abraham, S. Barrett, P. Barrett-Lee, Robert Brown, S. Chan, M. Dowsett, J. Flanagan, Lisa Fox, A. Grigoriadis, A. Gutin, C. Harper-wynne, M. Hatton, K. Hoadley, J. Parikh, P. Parker, C. Perou, R. Roylance, Vandna Shah, A. Shaw, I. Smith, K. Timms, A. Wardley, G. Wilson, C. Gillett, J. Lanchbury, A. Ashworth, N. Rahman, M. Harries, P. Ellis, S. Pinder, J. Bliss   +37 more
semanticscholar   +1 more source

Amodiaquine Enhances Anti‐Melanoma Efficacy of Attenuated Salmonella via Targeting Glutathione Reductase in Neutrophils

Advanced Science, EarlyView.
This study shows that Salmonella VNP20009 recruits pro‐tumor neutrophils that reduce its anticancer efficacy. Combining VNP with amodiaquine selectively eliminates these neutrophils by targeting glutathione reductase. A GR‐shRNA‐loaded VNP strain was further developed, demonstrating an innovative strategy integrating drug repurposing with synthetic ...
Wanfa Dong, Chunyuan Zhao, Chengxi Li, Lin Weng, Zehan Ji, Peiqi Li, Jiqiang Lu, Danni Liu, Anni Yu, Tianyi Jiang, Shaokai Huang, Heng Liu, Xiao Chen, Zichun Hua   +13 more
wiley   +1 more source