Results 121 to 130 of about 101,164 (260)

Canagliflozin Alleviates Diabetic Glomerular Endothelial Injury via Melibiose in a Microbiota‐Dependent Manner

Advanced Science, EarlyView.
Canagliflozin treatment reshapes the gut microbiota in DKD and elevates levels of melibiose, a metabolite derived from Roseburia intestinalis. Melibiose directly binds to and enhances the enzymatic activity of glyoxalase 1, leading to decreased methylglyoxal accumulation.
Wei Zhang, Yi Song, Changkun Li, Yuanyuan Luo, Mingwei Shao, Feng Guo, Fangyi Wei, Xunjie Fan, Wenwen Guo, Fengmei Xu, Yanhong Sang, Dongming Zhang, Yanhong Zhou, Lianwei Wang, Zhiqiang Kang, Yingjun Yang, Chunhua Song, Yanxia Liu, Xiaojun Ma, Jiao Wang, Chong Li, Shengnan Ma, Lin Zhao, Zhi Qin, Guolan Xing, Qiubo Zhao, Jun Li, Shumin Song, Dan Zhao, Ting Huang, Qingzhu Wang, Yanyan Zhao, Guijun Qin   +32 more
wiley   +1 more source

PRC2.1 Coordinates Peri‐Nucleolar H3K27me3‐Enriched Heterochromatin Organization and NPM1 Pentamerization to Maintain Nucleolar Integrity

Advanced Science, EarlyView.
PRC2.1(PCL2)‐coordinated H3K27me3‐enriched PNH establishes a spatial scaffold crucial for nucleolar integrity. As a crucial coordinator, PCL2 links PRC2.1 to chromatin organization and NPM1 assembly. This network‐based model reveals how chromatin modifications and nucleolar components cooperatively maintain nucleolar architecture, revealing novel ...
Lina Zhu, Wenqin Wang, Shuyun Chen, Gangyi Zhu, Zhen Wu, Yue Gu, Jingwen Xiong, Xu Zhang, Heng Liu, Kyoichi Isono, Youming Zhang, Jingjing Cao, Xiangzhi Li   +12 more
wiley   +1 more source

Metformin sensitizes triple-negative breast cancer to histone deacetylase inhibitors by targeting FGFR4

Journal of Biomedical Science
Background Triple-negative breast cancer (TNBC) is characterized by high malignancy, strong invasiveness, and a propensity for distant metastasis, leading to poor prognosis and relatively limited treatment options.
Zhangyuan Gu, Fugui Ye, Hong Luo, Xiaoguang Li, Yue Gong, Shiqi Mao, Xiaoqing Jia, Xiangchen Han, Boyue Han, Yun Fu, Xiaolin Cheng, Jiejing Li, Zhiming Shao, Peizhen Wen, Xin Hu, Zhigang Zhuang   +15 more
doaj   +1 more source

Real-world survival outcomes of neoadjuvant versus adjuvant chemotherapy in operable triple-negative breast cancer: a propensity score matched registry-based study

Acta Oncologica
Background and purpose: Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype where the prognostic implications of primary systemic therapy followed by surgery, compared to up-front surgery and subsequent adjuvant chemotherapy (ACT),
Ali Inan El-Naggar, Andreas Karakatsanis, Antonios Valachis   +2 more
doaj   +1 more source

A stemness-related ZEB1–MSRB3 axis governs cellular pliancy and breast cancer genome stability

, 2017
International audienceChromosomal instability (CIN), a feature of most adult neoplasms from their early stages onward, is a driver of tumorigenesis. However, several malignancy subtypes, including some triple-negative breast cancers, display a paucity of
Roxane M Pommier, Caroline Moyret-Lalle, Morel, Anne, Olivier Cabaud, Guitton, Jérôme, Penault-Llorca, Frédérique, Frédérique Penault-Llorca, Fauvet, Frédérique, Pommier, Roxane, Wang, Qing, Julien Wicinski, Finetti, Pascal, Jean-Luc Jauffret, Saintigny, Pierre, Despras, Emmanuelle, Vigneron, Arnaud, Hollande, Frédéric, Pinatel, Christiane, Puisieux, Alain, Combaret, Valérie, Valérie Combaret, Ruiz, Emmanuelle, Christiane Pinatel, Julie Caramel, Pierre Saintigny, Alain Puisieux, Emilie Thomas, Radosevic-Robin, Nina, Ansieau, Stéphane, Moyret-Lalle, Caroline, Emmanuelle Ruiz, Christophe Ginestier, Joël Lachuer, Tissier, Agnès, Thomas, Emilie, Birnbaum, Daniel, David G Cox, Charafe-Jauffret, Emmanuelle, Christelle Chassot, Frédéric Hollande, Daniel Birnbaum, Emmanuelle Despras, Caramel, Julie, Jérôme Guitton, Cabaud, Olivier, Emmanuelle Charafe-Jauffret, Pascal Finetti, Anne-Pierre Morel, Stéphane Ansieau, Mojgan Devouassoux-Shisheboran, Ginestier, Christophe, François Bertucci, Frédérique Fauvet, Arnaud M Vigneron, Anne Wierinckx, Agnès Tissier, Nina Radosevic-Robin, Wierinckx, Anne, Qing Wang, Wicinski, Julie, Chassot, Christelle, Devouassoux-Shisheboran, Mojgan, Bertucci, François, Jauffret, Jean-Luc, Lachuer, Joël, Cox, David   +65 more
core   +1 more source

HNRNPU K181 Lactylation Drives Cervical Cancer Growth by Upregulating PHGDH and Reprogramming Serine Metabolism

Advanced Science, EarlyView.
Lactate in cervical cancer induces HNRNPU K181 lactylation, opposed by NAA50‐mediated acetylation and suppressed by Pazopanib. This lactylation enhances HNRNPU binding to PHGDH pre‐mRNA exon 1, maintaining exon 1‐containing transcripts and mRNA stability, thereby activating serine metabolism.
Chang Zhang, Qingfei Meng, Hui Jiao, Huixin Liu, Xiangchao Wang, Honglan Zhou, Yishu Wang   +6 more
wiley   +1 more source

Integrated Single-Cell and Bulk RNA Sequencing Identifies SERPING1 as a Biomarker of Immune Infiltration and Prognosis in Triple-Negative Breast Cancer

Frontiers in Bioscience-Landmark
Background: Triple-negative breast cancer (TNBC) is an aggressive malignancy that lacks effective treatment. Immune infiltration plays an important role in anti-tumor responses.
Yuhang Shang, Runze Guo, Jiangwei Liu, Weilun Cheng, Anbang Hu, Yansong Liu, Yunqiang Duan, Xuelian Wang, Zhengbo Fang, Yanling Li, Hanyu Zhang, Mingcui Li, Zhiyuan Rong, Yuanhao Ji, Yulin Chen, Delong Cui, Yunyi Ji, Baoliang Guo   +17 more
doaj   +1 more source

Coordinated expression of ER, PR and HER2 define different prognostic subtypes among poorly differentiated breast carcinomas

, 2009
Aims: Histological grade is one of the most important prognostic factors in breast carcinomas, but poorly differentiated neoplasms still have quite heterogeneous biological behaviour, since they can be genetically classified as basal-like, HER2+ or even ...
SIQUEIRA, Sheila A. C., HEGG, Roberto, CARVALHO, Filomena M., FERNANDES, Raquel C. M., BEVILACQUA, Jose L. B., PIRES, Luis, SOARES, Ibere C.   +6 more
core   +1 more source

Covalent Inhibition of SHMT2 by Gambogic Acid Induces Ferroptosis Through Mitochondrial Collapse in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
In this study, chemoproteomics combined with genetic and functional analyses was integrated to identify SHMT2 as a covalent and functional target of gambogic acid (GA) in triple‐negative breast cancer (TNBC). Further validation demonstrated that GA selectively modifies the Cys241 site of SHMT2, triggering mitochondrial dysfunction, activating the Nrf2 ...
Tong Yang, Chong Qiu, Yulei Li, Ying Zhang, Chen Wang, Jie Zhou, Zheng Chu, Ang Ma, Ling Huang, Yin Kwan Wong, Junzhe Zhang, Peng Gao, Cui Liu, Junhua Zhang, Huan Tang, Jigang Wang   +15 more
wiley   +1 more source

Immunohistochemical analysis of Enolase-1 sublocalization in benign and malignant breast tumors: potential implications for tumor progression and prognosis

Frontiers in Oncology
Breast cancer is the second most common neoplasm in women and one of the main causes of premature mortality, with a high incidence before the age of seventy. Among its histological subtypes, invasive ductal carcinoma accounts for approximately 65% to 70%
Laura de Souza Baracioli, Caroline Patini Rezende, Luadna dos Santos e Silva, Débora de Lima Alves, Daniela Farias da Nóbrega, Luiz Gustavo de Almeida Chuffa, Debora Aparecida Pires Campos Zuccari   +6 more
doaj   +1 more source