Results 81 to 90 of about 101,312 (221)

Assessing the prognostic role of androgen receptor expression in non-metastatic triple-negative breast cancer

Frontiers in Oncology
BackgroundTriple negative breast cancer (TNBC) represents 15-20% of all invasive breast cancer with poor breast cancer survival. Androgen receptor (AR) expression in TNBC shows significant variability in the literature, with rates ranging from 7% to 75%.
Mahmoud Al-Masri, Mahmoud Al-Masri, Yasmin Safi, Basim Aljalabneh, Isam Jarah, Hussam Ananzeh, Rama AlMasri, Osama Alayyan, Fade Alawneh, Mohammad Almasri, Mohammad Almasri   +10 more
doaj   +1 more source

Microfluidic Nano‐Assembly of Red‐Blood‐Cell (RBC) Lipids and Components for Engineering Extracellular Vesicles

Advanced Healthcare Materials, EarlyView.
Engineered red blood cell‐derived extracellular vesicles (eRBCEVs) are synthesized via controlled microfluidic assembly from native RBC lipids, enabling tunable encapsulation of proteins, nucleic acids, nanoparticles, and viral vectors. The platform demonstrates reproducible nanoscale architecture, preserved membrane composition, and functional cargo ...
Chiranth K. Nagaraj, Xilal Y. Rima, Kim T. Nguyen, Courtney Culkins, Nana Boateng, Jacob Doon‐Ralls, Alejandro Bresolin, Xin Huang, Hong Li, Vahedi Amid, Ajeet Pal Singh, Dharti Shantaram, Anastasiia Amari, Mangesh D. Hade, Nicholas R. Merriam, Zachary D. Schultz, Scott Q. Harper, Nizar Y. Saad, Setty M. Magaña, Willa A. Hsueh, Rachel E. Kopec, Blaise R. Kimmel, Andre F. Palmer, Eduardo Reátegui   +23 more
wiley   +1 more source

MRI features of breast cancer immunophenotypes with a focus on luminal estrogen receptor low positive invasive carcinomas

Scientific Reports
To compare the magnetic resonance imaging (MRI) features of different immunophenotypes of breast carcinoma of no special type (NST), with special attention to estrogen receptor (ER)-low-positive breast cancer.
Carla Chizuru Tajima, Fernanda Pini Sapata Gonçalves Arruda, Victor Chequer Mineli, Julianna Moura Ferreira, Barbara Beltrame Bettim, Cynthia Aparecida Bueno de Toledo Osório, Marina Sonagli, Almir Galvão Vieira Bitencourt   +7 more
doaj   +1 more source

Multidimensional Cellular Micro‐Compartments to Model Invasive Lobular Carcinoma Dormancy

Advanced Healthcare Materials, EarlyView.
Invasive lobular carcinoma (ILC) is an understudied subtype of breast cancer that is susceptible to late recurrences. In this study, micro‐compartmentalization techniques spanning multiple dimensions, including 2D, pseudo‐3D, and 3D, are integrated to uncover the mechanisms underlying ILC dormancy, revealing the central role of p27Kip1.
Xilal Y. Rima, Sarmila Majumder, Divya S. Patel, Chunyu Hu, Hong Li, Xin Huang, Kim Truc Nguyen, Jacob Doon‐Ralls, Chiranth K. Nagaraj, Mangesh D. Hade, Setty M. Magaña, Eswar Shankar, Xiaoli Zhang, Daniel G. Stover, Bhuvaneswari Ramaswamy, Eduardo Reátegui   +15 more
wiley   +1 more source

Intelligent Orthopedics: Machine Learning in Diagnosis of Bone Disease, Implants, and Bone Health Monitoring

Advanced Healthcare Materials, EarlyView.
Efficient recovery from traumatic or degenerative diseases is a great challenge, even after all the advancements in bone and cartilage regeneration. Machine learning (ML) algorithms have presented opportunities to enhance these aspects by accurately analyzing imaging data.
Maryam Kamaei, Hesam Mohammadi, Shamim Golafshan, Mojtaba Alehosseini, Mahsa Mohammadzadeh, Atefeh Golshirazi, Nasim Golafshan, Tatiane Eufrásio‐da‐Silva, Alireza Dolatshahi‐Pirouz, Gorka Orive   +9 more
wiley   +1 more source

Angiovolume and Peak Enhancement on Preoperative CAD-Derived MRI as Prognostic Factors in Primary Operable Triple-Negative Breast Cancer

Tomography
Background/Objectives: To identify preoperative MRI features using computer-assisted diagnosis (CAD) that are associated with invasive disease-free survival (IDFS) and distant metastasis-free survival (DDFS) in patients with primarily operable triple ...
Bo La Yun, Sun Mi Kim, Sung Ui Shin, Su Min Cho, Yoon Yeong Choi, Mijung Jang   +5 more
doaj   +1 more source

Overcoming Photodynamic Therapy Resistance: GSH‐Responsive AIE Photosensitizer‐Hydroxycamptothecin Nanoliposomes for Extrahepatic Cholangiocarcinoma

Advanced Healthcare Materials, EarlyView.
A GSH‐responsive AIE nanoplatform (TSH NPs) with RGD‐mediated tumor targeting co‐delivers a photosensitizer (TPA) and HCPT for extrahepatic cholangiocarcinoma. The system synergistically enhances PDT and chemotherapy by suppressing HIF‐1α/VEGF‐driven hypoxic adaptation, effectively overcoming PDT resistance.
Yong Qu, Tao Peng, Yating Zhang, Juanmei Cao, Birong Wang, Chuxing Chai, Zhiyuan Gao, Yiting Xu, Yifan Jin, Yuqing Wang, Zhuoxia Li, Xu Liu, Tianqi Zhao, Yufan Chen, Weimin Lv, Di Lu, Changzheng Huang, Dan Ding, Jinxiang Zhang, Min Li   +19 more
wiley   +1 more source

Endogenous osteoprotegerin (OPG) represses ERα and promotes stemness and chemoresistance in breast cancer cells

Cell Death Discovery
Breast cancer (BC) is the most prevalent cancer and the leading cause of death among women worldwide. The osteoprotegerin (OPG) cytokine, a decoy receptor for RANKL and a key player in bone homeostasis, has pro-and anti-carcinogenic effects in various ...
Noura N. Alraouji, Dilek Colak, Falah H. Al-mohanna, Ayodele A. Alaiya, Abdelilah Aboussekhra   +4 more
doaj   +1 more source

Role of Chronic Psychological Stress Biomarkers in Triple-Negative Breast Cancer Progression

Link Medical Journal of Health and Community Research
Background: Triple-negative breast cancer (TNBC) is an aggressive subtype with limited therapeutic targets and variable disease progression. Emerging evidence suggests that chronic psychological stress and its biological correlates, particularly ...
Sajida Memon, Fareeha F Khan, Zainab Tanveer, Ayesha Khalid, Asad Hassnain, Amir Ali, Dua Jabbar   +6 more
doaj   +1 more source

Reprogramming the Immunosuppressive Microenvironment in Triple‐Negative Breast Cancer via FAP‐Targeted Nanoprobes for Multimodal Imaging and Photothermal Therapy

Advanced Materials, EarlyView.
Targeting cancer‐associated fibroblasts (CAFs) with fibroblast activation protein (FAP)‐directed nanoprobes for multimodal imaging and photothermal remodeling of the immunosuppressive microenvironment to enhance immunotherapy in triple‐negative breast cancer (TNBC).
Ling Zhan, Yanhong Chen, Jingjing Hu, Chunting Wang, Huanhuan Liu, Defan Yao, Dengbin Wang   +6 more
wiley   +1 more source