Results 81 to 90 of about 110,363 (266)

HAGE (DDX43) is a biomarker for poor prognosis and a predictor of chemotherapy response in breast cancer [PDF]

, 2014
Background: HAGE protein is a known immunogenic cancer-specific antigen. Methods: The biological, prognostic and predictive values of HAGE expression was studied using immunohistochemistry in three cohorts of patients with BC (n=2147): early primary (EP ...
A G Pockley, AC Wolff, AJ Linley, C Denkert, C Johnson, C Lurquin, CJ Piyathilake, CW Elston, DR Germain, E Dotan, E Yakirevich, EF Velazquez, G Qu, G R Ball, I O Ellis, J Kim, J Roman-Gomez, J Soares, JP Issa, L Harris, L Yang, L Zheng, L Zitvogel, LM McShane, M Clarke, M Otte, ME Hammond, MG Mathieu, MG Mathieu, MO Riener, N Harbeck, NC Wortham, P M Moseley, Q Chen, R C Rees, R Iggo, S E B McArdle, S Gluck, S Shin, S Y T Chan, SE Pinder, SP Adams, T Kurashige, T M A Abdel-Fatah, TM Abdel-Fatah, TM Abdel-Fatah, V Martelange, YI Kim, YT Chen   +48 more
core   +3 more sources

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Neoplastic transformation of porcine mammary epithelial cells in vitro and tumor formation in vivo. [PDF]

, 2015
BackgroundThe mammary glands of pigs share many functional and morphological similarities with the breasts of humans, raising the potential of their utility for research into the mechanisms underlying normal mammary function and breast carcinogenesis ...
Borowsky, AD, Cardiff, RD, Hovey, RC, Manjarin, R, Rowson-Hodel, AR, Trott, JF   +5 more
core  

Goiter frequency is more strongly associated with gastric adenocarcinoma than urine iodine level [PDF]

, 2013
Purpose: We designed our study to evaluate the hypothesis that gastric cancer is correlated with iodine deficiency or thyroid dysfunction. Materials and Methods: We investigated the total body iodine reserve, thyroid function status and autoimmune ...
Adabi, K., Haghpanah, V., Hatami, E., Heshmat, R., Jahangirrad, A., Keshtkar, A., Kia, A., Larijani, B., Nabizadeh, R., Rohani, D., Roshandel, G., Semnani, S., Tabaeizadeh, M.   +12 more
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Clinicopathologic Features and Survival of Breast Cancer Subtypes in Northeast Iran

Middle East Journal of Cancer, 2018
Background: Breast cancer can be categorized into different histopathological subtypes based on gene expression profiles. This study aims to evaluate the clinicopathological features and overall survival of various subtypes of breast cancer to assist ...
Soodabeh Shahidsales, Mona Joudi, Marjaneh Mirsadraee, Amir Avan, Saeideh Ahmadi Simab, Mohammad-Reza Ghavamnasiri   +5 more
doaj  

CHARACTERISTICS OF INDIVIDUALS UNDERGOING PANEL GENETIC TESTING FOR PRIMARY BRAIN TUMORS [PDF]

, 2018
Background. Currently, there are no genetic testing guidelines for patients with a primary brain tumor (PBT). This population is largely understudied in terms of the family history, tumor grade, pathology, and their relation to genetic contribution.
Azam, Sarah
core   +1 more source

Environmental Exposures during Puberty: Window of Breast Cancer Risk and Epigenetic Damage. [PDF]

, 2020
During puberty, a woman's breasts are vulnerable to environmental damage ("window of vulnerability"). Early exposure to environmental carcinogens, endocrine disruptors, and unhealthy foods (refined sugar, processed fats, food additives) are hypothesized ...
Aljaber, Dana, Au, Dawn, Benmarhnia, Tarik, Cardiff, Robert D, Chavez, Tanya, Dietze, Eric C, Doan, Stacey, Jankowska, Marta M, Jones, Veronica, McCune, Jeannine S, Natarajan, Rama, Nunez, Alan, Resto, Cristal, Sanchez, Angelica, Seewaldt, Victoria L, Serrano, Mayra, Sistrunk, Christopher, Thai, Christine, Tomsic, Jerneja, Yang, Jiue-An   +19 more
core   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source