Results 91 to 100 of about 928,403 (288)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

open access: yesMolecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala   +15 more
wiley   +1 more source

Triple Fused Supernumerary Kidneys with Five Pelvicalyceal Systems

open access: yesSociété Internationale d’Urologie Journal
We present a case of supernumerary kidney with fusion of all three kidney units with five pelvicalyceal system (bilateral bifid PCS and PCS of supernumerary kidney). This is probably the first such case reported in literature.
Naveen Kumar   +2 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

open access: yesMolecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung   +17 more
wiley   +1 more source

Configurations in triple systems: avoidance and decomposition

open access: yesLe Matematiche, 1992
See directly the article.
Alex Rosa
doaj  

Super Jordan triple systems and Kantor triple systems

open access: yes, 2019
We introduce the notion of $ \epsilon $-super Jordan triple systems(sJTS), a supersymmetric generalization of Jordan triple systems which includes them as well as the class of N=6 3-algebras as particular cases. The Tits-Kantor-Koecher construction for Kantor triple systems(KTS) and for $ \epsilon $-super Jordan triple systems is established and ...
openaire   +2 more sources

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

open access: yesMolecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris   +10 more
wiley   +1 more source

A Triple Scenario for the Formation of Wide Black Hole Binaries Such as Gaia BH1

open access: yesThe Astrophysical Journal
Recently, several noninteracting black hole–stellar binaries have been identified in Gaia data—for example, Gaia BH1, where a Sun-like star is in a moderately eccentric ( e = 0.44) 185 days orbit around a black hole.
A. Generozov, H. B. Perets
doaj   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon   +9 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

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