Results 61 to 70 of about 2,851,507 (299)

Variable impact on mortality of AIDS‐Defining events diagnosed during combination antiretroviral therapy: Not All AIDS‐defining conditions are created equal [PDF]

, 2009
Background The extent to which mortality differs following individual acquired immunodeficiency syndrome (AIDS)–defining events (ADEs) has not been assessed among patients initiating combination antiretroviral therapy.
Justice, Amy, Saaq, M., Crevel, R. van, Sterne, Jonathan A C, Justice A., Reiss, Peter, HARRIS R, R. Harris, Staszewski, S., Mocroft, A., Sabin, Caroline, G. Fatkenheuer, D'Arminio-Monforte, A., Fatkenheuer, G., Egger, M., Phillips, E., Groot, R. de, Harris, Ross, Gill J., KITAHATA M, S. Grabar, Sterne, J.A., F. Bonnet, May, M., Post, F., CASABONA J, A. Justice, Ven, A.J.A.M. van der, Mocroft, A, Casabona J., H. Furrer, J. Casabona, M. Egger, Reiss P., Antiretroviral Therapy Cohort Collaboration, Casabona, Jordi, D'ARMINIO MONFORTE A, FATKENHEUER G, STERNE JA, De Wit, Stéphane, Kitahata, Mari, Furrer H., d'Arminio Monforte, Antonella, Bonnet, F., C. Sabin, Sterne, Jonathan A. C., MONTRONI, MARIA, MAY M, SAAG M., Furrer, H., A. Mocroft, Staszewski, Schlomo, Justice, Amy C, Justice, A., MINOLI, LORENZO, Reiss, P., Sabin C., MANCUSO, Salvatrice, Antiretroviral Therapy Cohort Collaboration Mocroft A., Saag, Michael, Saag, M., J. Gill, Keuter, M., Warris, A., Hogg R., Staszewxski S., Sterne J.A., Clumeck, Nathan, S. Staszewski, Casabona, J., P. Reiss, Bonnef, VULLO, Vincenzo, Kitahata, M., Mocroft, Amanda, Furrer, Hansjakob, Koopmans †, P.P., Gill, J., Gill, John, Bonnet, Fabrice, GRABAR S, REISS P, ?, ?, Hogg, Robert, M. Kitahata, CIARDI, Maria Rosa, et al., EGGER M, Niesters, Bert, Egger, Matthias, Harris R., Fatkenheuer G., May, Margaret T, JUSTICE A, HOGG R, May M., Grabar, Sophie, Fatkenheuer, Gerd, ANTIRETROVIRAL THERAPY COHORT COLLABORATION ART CC, May, Margaret, Egger M., d'Arminio Monforte A., M. May, GILL J, Grabar S., D'Arminio Monforte, A., Grabar, S., A. d'Arminio Monforte, Kitahata M., SABIN C, R. Hogg, Harris, R., Sabin, C., Post, Frank, J. A. Sterne, STASZEWSKI S, FURRER H, Gyssens, I.C.J., MOCROFT A, M. Saag, Hogg, R., BONNET F   +121 more
core   +3 more sources

The cost-effectiveness of sequential versus standard triple therapy for Helicobacter pylori eradication in Saudi Arabia

The Saudi Journal of Gastroenterology, 2021
Background: The utilization rate of different treatment regimens for Helicobacter pylori infection is believed to be high; however, the cost-effectiveness of these regimens has not been examined before. Therefore, the aim of this study was to examine the
Yazed AlRuthia, Majid A Almadi, Sadeem Alqahtani, Hala Alrasheed, Mohammad Al-Owairdhi, Fahad Alsohaibani   +5 more
doaj   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Triple P - Positive Parenting Program: Group Triple P [PDF]

, 2015
FlyerGroup Triple P is a great way to meet other parents facing the same issues as you. Each group has about 10 or 12 parents, so you won’t feel alone!
Barnardos, Triple P
core   +2 more sources

Comparative Efficacy and Safety of Triple Therapy (Ramipril, Telmisartan, Hydrochlorothiazide) Vs Dual Anti Hypertensive Therapy (Ramipril or Telmisartan, Hydrochlorothiazide) in Stage 2 Hypertensive Patients [PDF]

Journal of Clinical and Diagnostic Research, 2014
Aim: To evaluate the comparative efficacy and safety of ramipril 5mg plus hydrochlorothiazide 12.5mg (R + HCTZ), telmisartan 40mg plus hydrochlorothiazide12.5mg (T + HCTZ) and ramipril 2.5mg plus telmisartan 20mg plus hydrochlorothiazide12.5mg (R + T
Bharat Bhushan, Seema Gupta, Vijay Khajuria, Dinesh Kumar, Mohan Lal, Dharminder Kumar, Sanjeev Bhat, Aman Sharma   +7 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Triple Connected Domination Number of a Graph [PDF]

, 2012
The concept of triple connected graphs with real life application was introduced by considering the existence of a path containing any three vertices of a graph G.
Selvam Avadayappan, T.Subramanian, Joseph, Paulraj, J.Paulraj Joseph, G.Mahadevan, Avadayappan, Selvam, Subramanian, T., Mahadevan, G.   +7 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source