Results 81 to 90 of about 2,238,792 (224)

TPMS-based metamaterials with tuneable elastic anisotropy and mechanical coupling

Materials & Design
Architectured metamaterials typically comprise of unit cells with cubic stiffness tensors and this cubic symmetry greatly restricts the available design space of mechanical properties than can be attained. In this paper, this conventional design approach
Stephen Daynes
doaj   +1 more source

Collagen‐Binding IL‐15 Immunocytokine Armed Oncolytic Adenovirus Establishes a Self‐Reinforcing Immunostimulatory Milieu to Potentiate Antitumor Immunity

Advanced Science, EarlyView.
Repurposing the dense tumor stroma from a physical barrier into an anchoring scaffold, an engineered oncolytic adenovirus encoding IL15C‐CBD overcomes the immunosuppressive microenvironment in triple‐negative breast cancer. Intratumoral viral replication secretes this collagen‐anchored immunocytokine, forming a localized cytokine depot.
Yaqi Yang, Xiaoxiao Liu, Junqiang Ding, Jinliang Xu, Jianhua Zhang, Hanchang Zhang, Rong Yang, Sha Li, Lu Zheng, Runping Su, Yue Zhao, Jianxiao Wu, Hao Li, Changyou Zhan, Xihui Gao   +14 more
wiley   +1 more source

Investigation of torsional and fatigue resistance properties based on triply periodic minimal surfaces (TPMS)

Journal of Physics: Conference Series
Abstract Triply periodic minimal surfaces (TPMS) are algebraic surfaces found in nature, defined by implicit functions, and exhibit exceptional properties in various fields such as mechanics, computer graphics, and tissue engineering.
Jijun Jiang, Zhanlong Cao, Jing Wu, Hongwei Lu, Jiahao Zhang   +4 more
openaire   +1 more source

Tracking CDK1 Dynamics With a Novel Biosensor Mouse and Clinical Cohorts to Predict CDK4/6 Inhibitor Sensitivity in ER+ Breast Cancer

Advanced Science, EarlyView.
Cyclin‐dependent kinase (CDK) 1 activity is a dynamic marker of treatment response in estrogen receptor positive breast cancer. Patient cohorts reveal CDK1 activity increases during progression to invasive disease, where high expression correlates with poor survival. Using a novel Cdk1 biosensor mouse alongside in vitro models, we demonstrate that CDK1
Sarah Alexandrou, Kristine J. Fernandez, Min Li Huang, Ewan K. A. Millar, Claire Vennin, Leila Eshraghi, Tan Dat Timothy Lam, Victoria Lee, Nyah C. Brooks, Janett Stoehr, Cristian Guaman Mendez, Douglas Strathdee, David Stevenson, David Herrmann, Sandra O'Toole, Paul Timpson, Max Nobis, C. Elizabeth Caldon   +17 more
wiley   +1 more source

Holomorphic curves and minimal surfaces in Kähler manifolds [PDF]

Our work is concerned with the relation between a complex differential geometric property, namely holomorphicity, and a metric one, namely to be conformal and minimal, of immersions (possibly branched) of Riemann surfaces into Kahler manifolds. A well
Arezzo, Claudio
core  

Shape-memory polymer metamaterials based on triply periodic minimal surfaces

, 2022
Triply periodic minimal surfaces (TPMS) metamaterials and shape-memory polymer (SMP) smart materials are known for their beneficial attributes in novel scientific and industrial fields.
Jebellat, Ehsan (author), Baghani, Mostafa (author), Famouri, Seyedfarzad (author), Baniasadi, Mahdi (author), Hedayati, R. (author), Roudbarian, Nima (author)   +5 more
core   +1 more source

Galactokinase 1 Positively Regulates Mitochondrial Respiration by Phosphorylating TIMM13 as a Protein Kinase

Advanced Science, EarlyView.
GALK1 acts as a protein kinase beyond the phosphorylation of galactose. GALK1 phosphorylates TIMM13 at Y73 in the cytoplasm. This phosphorylation prevents premature oxidative folding of TIMM13 and ensures its entrance into the intermembrane space of mitochondrion, positively regulating mitochondrial respiration.
Chang Woo Ko, Dongyoon Shin, Junho Park, June Huh, Youngsoo Kim, Jong‐Wan Park   +5 more
wiley   +1 more source

Experimental investigation of Triply Periodic Minimal Surfaces for high-temperature solar receivers

Case Studies in Thermal Engineering
This study experimentally investigates Triply Periodic Minimal Surfaces (TPMS) as structured porous media for concentrated solar power systems. Two mock-up planar solar receivers with different TPMS lattices, Diamond and SplitP, were fabricated using ...
A. Mortazavi, A.L. Ávila-Marín, H. Ebadi, E. Gajetti, C. Piatti, L. Marocco, L. Savoldi   +6 more
doaj   +1 more source

Enhancing Specific Stiffness of Nano‐Architected Materials Through Generative AI and Active Learning

Advanced Science, EarlyView.
A structure‐centric generative framework searches voxelated design space directly, coupling a variational autoencoder with multi‐objective optimization and active learning to progressively expand the validated design domain. The discovered nano‐architectures, realized as pyrolytic carbon by two‐photon lithography, deliver 18–23% higher stiffness and 26–
Jinwook Yeo, Peter Serles, Donggeun Park, Julia R. Greer, Seunghwa Ryu   +4 more
wiley   +1 more source

Lactate‐H3K18la‐RPL11 Axis Drives Gemcitabine Resistance in Pancreatic Cancer by Integrating Protein Synthesis and DNA Damage Repair

Advanced Science, EarlyView.
A lactate‐H3K18la epigenetic axis upregulates RPL11 to drive gemcitabine resistance in pancreatic cancer. RPL11 orchestrates chemoresistance through a dual, compartmentalized role: enhancing cytoplasmic protein synthesis via EEF1A1 stabilization and promoting nuclear DNA damage repair by co‐activating PARP14, thus ensuring robust cell survival ...
Lijun Zhao, Jianzhong Cao, Wenyue Liu, Xuyun Li, Haolin Zhang, Xiaofang Zhang, Shiyang Shi, Huilong Yin, Junjie Li, Angang Yang, Rui Zhang   +10 more
wiley   +1 more source