Results 101 to 110 of about 45,296 (245)

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

British Journal of Pharmacology, EarlyView.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown, Alan Armstrong, David J. Mann   +2 more
wiley   +1 more source

Optimization of triterpenoids biosynthesis in Athelia termitophila as a source of natural products

AMB Express
Triterpenoids exhibit considerable potential and are extensively utilized in both food and pharmaceutical industries. However, Athelia termitophila (TMB) naturally harbors only trace amounts of these compounds. Consequently, this study sought to optimize
Fangcheng Hu, Yonggang Fang, Zahid Khan, Lianxi Xing   +3 more
doaj   +1 more source

Two New Triterpenoids from the Roots of Codonopsis pilosula

Molecules, 2018
Pseudolarolides U and V, two new triterpenoids, and four biogenetically related compounds, pseudolarolides E, F, K, and P were isolated from the roots of Codonopsis pilosula (Campanulaceae). Their structures were determined by spectroscopic data.
Tao Zheng, Li-Zhi Cheng, Yong-Ming Yan, Bao-Hua Liu, Fu-Ying Qin, Fu-Rong Xu, Yong-Xian Cheng   +6 more
doaj   +1 more source

Therapeutic potential of natural products in cancer immunotherapy: Advances and challenges

British Journal of Pharmacology, EarlyView.
This review systematically outlines the mechanisms underlying tumour immunotherapy resistance and elucidates the role of natural products in enhancing therapeutic efficacy as immunomodulatory adjuvants. Abstract Immunotherapy has emerged as a clinically pivotal approach in cancer treatment, but its application remains limited to a small subset of ...
Rao Hu, Kaibin Dai, Zhensheng Lin, Mingfang Ye, Minfeng Chen, Xiaobo Li, Dongmei Zhang   +6 more
wiley   +1 more source

The multidimensional regulation roles and mechanisms of calcium in fruit quality

Journal of Integrative Plant Biology, EarlyView.
This review explores how calcium signaling molecule integrates plant hormones, environmental cues, and developmental signals to influence external fruit traits, internal nutritional properties, and physiological disorders. ABSTRACT Calcium (Ca2+), a dual‐functional mineral that serves both as an essential structural factor and a signaling molecule ...
Fei Jiang, Siyang Gao, Mengdi Li, Zeqi Zhao, Chengwei Yang, Ji‐Hong Liu, Chunlong Li   +6 more
wiley   +1 more source

Promiscuous, Multi-Target Lupane-Type Triterpenoids Inhibits Wild Type and Drug Resistant HIV-1 Replication Through the Interference With Several Targets

Frontiers in Pharmacology, 2018
Current research on antiretroviral therapy is mainly focused in the development of new formulations or combinations of drugs belonging to already known targets. However, HIV-1 infection is not cured by current therapy and thus, new approaches are needed.
Luis M. Bedoya, Luis M. Bedoya, Manuela Beltrán, Javier García-Pérez, Patricia Obregón-Calderón, Oliver Callies, Ignacio A. Jímenez, Isabel L. Bazzocchi, José Alcamí   +8 more
doaj   +1 more source

Pangenome analysis reveals the genetic mechanism underlying high‐altitude adaptation in Qinghai–Xizang (Tibet) Plateau Rhododendron

Journal of Integrative Plant Biology, EarlyView.
Pan‐genome analysis reveals that high‐altitude Rhododendron species resist alpine cold stress by rapidly sensing and engaging the chilling response pathway and genes that directly and indirectly protect the plant from UV radiation. Heritable genomic features such as long terminal repeats contribute to the adaptive diversification of Rhododendron ...
Haoyang Zhou, Zhongping Xu, Fanhuang Zeng, Haiyu Sang, Zhenhua Liu, Miao Sun, Qiang Fu, Kaige Zhao, Daming Tan, Manzhu Bao, Shuangxia Jin, Xiuqun Liu   +11 more
wiley   +1 more source

Two New Triterpenoids from Lysimachia heterogenea Klatt and Evaluation of Their Cytotoxicity

Molecules, 2011
Two new 13,28-epoxy oleanane-type triterpenoids, namely heterogenoside E and F, were isolated from Lysimachia heterogenea Klatt, together with the eight known compounds: palmitic acid, β-stigmasterol, kaempferol, quercetin, hyperin, isorhamnetin ...
Xin-Xin Zhou, Feng-Xue Zhang, Kang-Lun Liu, Ya-Ming Liu, Ying-Jie Hu, Xiao-Ling Shen, Xin-An Huang   +6 more
doaj   +1 more source

Why do Euphorbiaceae tick as medicinal plants? : a review of Euphorbiaceae family and its medicinal features [PDF]

, 2011
Euphorbiaceae is among the large flowering plant families consisting of a wide variety of vegetative forms some of which are plants of great importance. Its classification and chemistry have of late been subjects of interest possibly because of the wide ...
Mwine, Tedson Julius, Van Damme, Patrick
core  

Chromosome‐Level Genome Assembly of the Allotetraploid Gynostemma pentaphyllum Provides Novel Insights Into the Biosynthesis of Ginsenoside and Gypenoside LVI

Plant Biotechnology Journal, EarlyView.
ABSTRACT Gynostemma pentaphyllum, a herb used in tea and traditional Chinese medicine, shows geographic variation in its production of valuable dammarane‐type ginsenosides and gypenoside LVI between populations from Suining (SN) and Nanning (NN). To elucidate the mechanisms underlying this differential metabolite accumulation, a chromosome‐level genome
Peina Zhou, Si‐Jie Liu, Lijin Huang, Yingping Wang, Xinyu Jiang, Wang Dong, Jianfeng Gong, Long Wang, Yuyin Zhao, Huiying Wang, Ping Li, Jia‐Yu Xue, Xu Lu   +12 more
wiley   +1 more source