Results 51 to 60 of about 19,319 (179)

Chemopreventive Effect of Bitter Melon (Momordica charantia) Juice on Pancreatic Carcinogenesis in LSL‐KrasG12D/+; p48Cre/+ Mice

Molecular Carcinogenesis, EarlyView.
ABSTRACT Herein, using the LSL‐KrasG12D/+; p48Cre/+ transgenic mouse model [that recapitulates the full spectrum of human disease, progressing from early pancreatic intraepithelial neoplasia lesions to invasive pancreatic ductal adenocarcinoma (PDAC)], we determined the chemopreventive effect of long‐term (chronic) administration of Bitter Melon Juice (
Lakshmi Sai Pratyusha Bugata, Deepanshi Dhar, Rama Kant, Robin Kumar, Md. Imtiazul Kabir, Chapla Agarwal, Rajesh Agarwal, Komal Raina   +7 more
wiley   +1 more source

Four New Triterpenoids from Callicarpa kwangtungensis

Molecules, 2015
Four new triterpenoids which were identifed as 2α,3β,6β,19α-tetrahydroxy- oleanolic acid 28-O-β-D-glucopyranoside (1), 2-O-β-D-glucopyranosyloxy-3α,19α-di-hydroxyoleanolic acid (2), 2-O-β-D-glucopyranosyloxy-3α,19α-dihydroxyursolic acid (3), 2α,3α,6β,19α-
Guo-Ping Zhou, Yan Yu, Ming-Ming Yuan, Tengfei Ji, Hui-Zheng Fu, Rui-Jian Zhong   +5 more
doaj   +1 more source

Decoding Molecular Mechanisms of Pongamia pinnata Phytochemicals in Cancer Therapy

Medicine Advances, EarlyView.
Pongamia pinnata phytochemicals have multiple anticancer mechanisms, including antioxidant, anti‐inflammatory, anti‐metastatic, and apoptosis‐inducing activities through molecular‐level regulation. These bioactive compounds protect normal cells from oxidative stress while promoting reactive oxygen species‐mediated tumor cell death and suppressing ...
Rajib Dhar, Vetriselvan Subramaniyan
wiley   +1 more source

Quality Difference Study of 6 Varieties of Ganoderma Lucidum with Different Origins

Frontiers in Pharmacology, 2012
The quality difference of 6 varieties Ganoderma Lucidum with different origins was investigated in this study by comparing the contents of ganoderic acid A and B, polysaccharide and triterpenoids .The contents of ganoderic acid A and B in G.lucidum were ...
Juan eLu, Jia-zhang eQin, Ping eChen, Xi eChen, Ying-Zhi eZhang, Si-jia eZhao   +5 more
doaj   +1 more source

From wild to tamed: Reimagining novel crops through omics and local plant diversity

PLANTS, PEOPLE, PLANET, EarlyView.
The global food system faces growing pressure from climate change, biodiversity loss, and rising nutritional demands. Agriculture has increased yields but reduced crop diversity, flavor, and nutritional quality, leaving societies vulnerable and dependent on a narrow set of staple species.
Alexandra Sanfeliu Meliá, Pablo D. Cárdenas   +1 more
wiley   +1 more source

Extraction of triterpenoids from Carya cathayensis Sarg. husks and enhancement of their antibacterial properties by loading into chitosan aerogels

Food Innovation and Advances
Carya cathayensis Sarg. is widely cultivated in China as a specialized nut crop, and its discarded husks (outer pericarp) are rich in triterpenoids with known antibacterial properties.
Haixin Sun, Xinya Gu, Baozhu Shi, Tianhua Huang, Junlai Nian, Jidong Sun, Tarun Belwal, Liezhou Zhong, Benu Adhikari, Zisheng Luo   +9 more
doaj   +1 more source

Synthesis and Cytotoxicity Evaluation of DOTA-Conjugates of Ursolic Acid

Molecules, 2019
In this study, we report the synthesis of several amine-spacered conjugates of ursolic acid (UA) and 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA).
Michael Kahnt, Sophie Hoenke, Lucie Fischer, Ahmed Al-Harrasi, René Csuk   +4 more
doaj   +1 more source

Betulinic Acid Enema Alleviates Colitis by Targeting Vitamin D Receptor to Protect the Intestinal Mucosal Barrier and Modulate Mucosa‐Associated Microbiota

Phytotherapy Research, EarlyView.
ABSTRACT Ulcerative colitis (UC) is a chronic inflammatory disease of the colon with limited effectiveness and safety of current drug therapies. Betulinic acid (BA) is a naturally occurring pentacyclic triterpenoid present in traditional Chinese medicines used clinically as retention enemas for UC, but its direct effects and mechanisms remain unclear ...
Lina Dong, Yuanxia Gao, Qian Li, Guangxin Chen, Dong Yang, Liping Zhao, Xiaojing Liu, Shumei Lin   +7 more
wiley   +1 more source

Development of a Tandem Mass Spectral Library for the Detection of Triterpenoids in Plant Metabolome Based on Reference Standards

Plants
Plant triterpenoids represent a diverse group of secondary metabolites and are thought to be valuable for therapeutic applications. For drug development, lead optimization, better knowledge of biological pathways, and high-throughput detection of ...
Bibi Zareena, Syed Usama Y. Jeelani, Adeeba Khadim, Arslan Ali, Jalal Uddin, Satyajit D. Sarker, Matthias Rainer, Shaden A. M. Khalifa, Hesham R. El-Seedi, Muhammad Ramzan, Syed Ghulam Musharraf   +10 more
doaj   +1 more source

A-Ring-Modified Triterpenoids and Their Spermidine–Aldimines with Strong Antibacterial Activity

Molbank, 2019
Synthesis of A-ring-modified lupane, oleanane and ursane type triterpenoid conjugates with spermidine through an aldimine linkage or diethylentriamine via an amide bond is described.
Oxana B. Kazakova, Jean Michel Brunel, Elmira F. Khusnutdinova, Sophie Negrel, Gulnara V. Giniyatullina, Tatyana V. Lopatina, Anastasiya V. Petrova   +6 more
doaj   +1 more source