Results 51 to 60 of about 45,296 (245)

18β‐Glycyrrhetinic Acid and a Nano‐Liposomal Formulation Alleviate Depression‐Like Behaviors via the Microglial mTOR‐Autophagy‐NLRP3 Axis

Advanced Science, EarlyView.
Using a novel zebrafish‐based inflammatory screening strategy, we screened and identified 18β‐glycyrrhetinic acid (18β‐GA) as a promising anti‐inflammatory candidate. We uncover a microglial mTOR–autophagy–NLRP3 axis that constitutes the mechanistic core of 18β‐GA–mediated neuroprotection.
Hua Gan, Haitao Yuan, Wenjun Zhu, Xiaokang Xie, Shen Zhou, Wenzhi Hao, Xiaowei Mo, Lian Yang, Xiaojuan Li, Junshan Liu, Lijuan Deng, Jiaxu Chen   +11 more
wiley   +1 more source

Neuroprotective prospectives of triterpenoids

Exploration of Neuroscience
Neurological disorders including neurodegenerative disorders continue to pose significant therapeutic challenges. Triterpenoids, a diverse group of natural compounds found abundantly in plants, possess promising neuroprotective properties.
Apoorva A. Bankar, Vaishali P. Nagulwar, Nandkishor R. Kotagale, Nazma N. Inamdar   +3 more
doaj   +1 more source

GAME9 regulates the biosynthesis of steroidal alkaloids and upstream isoprenoids in the plant mevalonate pathway [PDF]

, 2016
Steroidal glycoalkaloids (SGAs) are cholesterol-derived molecules produced by solanaceous species. They contribute to pathogen defence but are toxic to humans and considered as anti-nutritional compounds.
Aharoni, Asaph, Burdman, Saul, Cárdenas, Pablo D, Dewangan, Veena, Giri, Ashok P, Goossens, Alain, Malitsky, Sergey, Meir, Sagit, Pollier, Jacob, Rogachev, Ilana, Sonawane, Prashant D, Tal, Lior, Vanden Bossche, Robin, Weithorn, Efrat   +13 more
core   +1 more source

A leaf phenomics approach for estimating belowground traits in North American licorice

American Journal of Botany, EarlyView.
Abstract Premise Selective breeding over thousands of years has prioritized aboveground yield, with little regard for changes belowground. Roots underpin plant growth and resilience, but our knowledge of these critical structures lags behind that of aboveground structures.
Zachary N. Harris, Vivian Tran, Emelyn Piotter, Meredith T. Hanlon, Matthew J. Rubin, Allison J. Miller   +5 more
wiley   +1 more source

Intrapopulation Genotypic Variation of Foliar Secondary Chemistry during Leaf Senescence and Litter Decomposition in Silver Birch (Betula pendula) [PDF]

, 2017
Abundant secondary metabolites, such as condensed tannins, and their interpopulation genotypic variation can remain through plant leaf senescence and affect litter decomposition.
Karvinen, Heini, Keinänen, Markku, Keski-Saari, Sarita, Mikola, Juha, Paaso, Ulla, Rousi, Matti, Silfver, Tarja   +6 more
core   +1 more source

Enhanced Rheological and Filtration Performance of Drilling Fluids Using Fe3O4/Saponin/Cu(II) Nanocomposites: Synthesis, Characterization, and Application

Asia-Pacific Journal of Chemical Engineering, EarlyView.
ABSTRACT Drilling fluids used in high‐performance well operations often struggle to maintain rheological stability, colloidal dispersion, and filtration control under harsh downhole conditions. This study engineered a multifunctional Fe3O4@Saponin/Cu(II) nanocomposite to address these challenges.
Kassem Al Attabi, Farag M. A. Altalbawy, Hana Ihsan Hassan, Ahmed Salih Sahib, Zahraa Saad Abdulali, Mariem Alwan, Mahmood Jawad, Hiba Mushtaq, Aseel Smerat, Fatimah Pashtun   +9 more
wiley   +1 more source

In silico identification of natural products from Centella asiatica as severe acute respiratory syndromecoronavirus 2 main protease inhibitor

Journal of Advanced Pharmaceutical Technology & Research, 2021
Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) main protease (S-CoV-2 Mpro) is one of the main targets in designing antiviral against SARS-CoV-2. Centella asiatica contains several triterpenoids, polyacetylenes, and benzoic ester derivative
Putu Gita Maya, Widyaswari Mahayasih, Harizal, Herman, Islamudin Ahmad   +4 more
doaj   +1 more source

The last forests on Antarctica: Reconstructing flora and temperature from the Neogene Sirius Group, Transantarctic Mountains [PDF]

, 2018
Fossil-bearing deposits in the Transantarctic Mountains, Antarctica indicate that, despite the cold nature of the continent’s climate, a tundra ecosystem grew during periods of ice sheet retreat in the mid to late Neogene (17–2.5 Ma), 480 km from the ...
Ackert, Ashworth, Ashworth, Ashworth, Askin, Askin, Baas, Barrett, Bechtel, Beerling, Bendle, Biellmann, Biellmann, Bowman, Burckle, Bush, Caldicott, Carlquist, Christopher H. Vane, Cline, Cranwell, Cranwell, Dettmann, Diefendorf, Diefendorf, Diefendorf, Diefendorf, Domínguez, Eberle, Eglinton, Ficken, Ficken, Ficken, Fiona L. Gill, Fleming, Francis, Giri, Han, Hautevelle, Hemsley, Hill, Hill, Huang, James B. Riding, Jane E. Francis, Karrer, Kemp, Kolattukudy, Lawver, Lewis, Lewis, Lopes dos Santos, Marchand-Geneste, Mercer, Männistö, Nakamura, Nierop, Nott, Otto, Otto, Otto, Otto, Pancost, Peterse, Peterse, Pollard, Prebble, Pross, Raine, Raquel A. Lopes dos Santos, Retallack, Rhian L. Rees-Owen, Robert J. Newton, Ruza F. Ivanović, Shaver, Simoneit, Sinninghe Damsté, Stroeven, Stránský, Tavendale, Tavendale, Trendel, Volkman, Warny, Webb, Webb, Webb, Weijers, Weijers, Wilmesmeier, Yamamoto, Zachos   +91 more
core   +3 more sources

Ursolic Acid Alleviates Orchitis via Modulating Ferroptosis in Peritubular Myoid Cells of Testis

Animal Research and One Health, EarlyView.
Ursolic acid modulates key ferroptosis‐related pathways in the peritubular myoid cells of the testis in forest musk deer. ABSTRACT Chronic stress adversely affects reproductive health, increasing susceptibility to pathologies such as orchitis. Additionally, the maintenance of iron homeostasis is essential for preserving the function of the testicles ...
Yang Wang, Tianqi Jin, Zexin Chen, Ye Gong, Qimin Liu, Zifang Wu, Heran Cao, Yan Li, Yuyan Liu, Tianhao Yang, Zhihong Jiang, Wuzi Dong   +11 more
wiley   +1 more source

Betalains and phenolic compounds of leaves and stems of Alternanthera brasiliana and Alternanthera tenella [PDF]

, 2018
Betacyanins and phenolic compounds from acetonitrile:acidified water extracts of Alternanthera brasiliana and Alternanthera tenella were characterized and quantified using a high-performance liquid chromatography system coupled with diode array and ...
Alvarez, I., De Ancos, B., Deladino, Lorena, Molina García, A. D., Schneider Teixeira, Aline, Sánchez Moreno, C.   +5 more
core   +1 more source