Results 61 to 70 of about 113,418 (280)

The anticancer effect of the HDAC inhibitor belinostat is enhanced by inhibitors of Bcl‐xL or Mcl‐1 in ovarian cancer

Molecular Oncology, EarlyView.
The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine, Sterenn Guillemot, Louis‐Bastien Weiswald, Romane Florent, Edwige Abeilard, Florence Giffard, Emilie Brotin, Mélanie Briand, Enora Dolivet, Laurent Poulain, Marie Villedieu   +10 more
wiley   +1 more source

Evaluation of TGF-Beta 2 and VEGFα Gene Expression Levels in Epiretinal Membranes and Internal Limiting Membranes in the Course of Retinal Detachments, Proliferative Diabetic Retinopathy, Macular Holes, and Idiopathic Epiretinal Membranes

Journal of Ophthalmology, 2018
Purpose. To evaluate the expression profiles of the VEGFα and TGFβ in the ERMs and ILMs in retinal disorders. Methods. In this nonrandomized prospective study, 75 patients (34 females and 41 males) referred to pars plana vitrectomy (PPV) due to different
Joanna Stafiej, Karolina Kaźmierczak, Katarzyna Linkowska, Paweł Żuchowski, Tomasz Grzybowski, Grażyna Malukiewicz   +5 more
doaj   +1 more source

Comparison of different methods for preparation and characterization of total RNA from cartilage samples to uncover osteoarthritis in vivo

BMC Research Notes, 2010
Background The isolation of intact RNA can be very difficult when tissues are used that contain many RNAses or that are hard to homogenize, e.g. cartilage samples.
Neumann Steffi, Ruettger Anke, Wiederanders Bernd, Huber René   +3 more
doaj   +1 more source

新たな転写因子の検索法についての研究　BRAK遺伝子の発現上昇に関与する転写因子の検索 [PDF]

, 2016
抗腫瘍性ケモカインBRAK/CXCL14遺伝子の発現上昇に関与する転写因子の検索として、ナラプロテクノロジーのデータマイニングを使用する方法を試みた。マイクロアレイのチップとしてヒトの約1万遺伝子を1枚のスライドグラスに搭載したものを使用し、高密度培養でBRAKと共に発現が上昇したものは1883個、低下が2148個存在した。これらを群分けして発現制御に関わるシグナル伝達経路をKyoto Encyclopedia Genes and Genomes PATHWAY等を参考に検討し、SP1、BACH2 ...
吉田 羊子
core   +1 more source

Integrative miRNOMe profiling reveals the miR‐195‐5p–CHEK1 axis and its impact on luminal breast cancer outcomes

Molecular Oncology, EarlyView.
In luminal (ER+) breast carcinoma (BC), miRNA profiling identified miR‐195‐5p as a key regulator of proliferation that targets CHEK1, CDC25A, and CCNE1. High CHEK1 expression correlates with worse relapse‐free survival after chemotherapy, especially in patients with luminal A subtype.
Veronika Boušková, Marie Ehrlichová, Alžběta Spálenková, Ivona Krus, Simona Šůsová, Viktor Hlaváč, Vlasta Němcová, Renata Koževnikovová, Markéta Trnková, David Vrána, Jiří Gatěk, Kateřina Kopečková, Marcela Mrhalová, Soňa Měšťáková, Pavel Souček   +14 more
wiley   +1 more source

TRIzol treatment of secretory phase endometrium allows combined proteomic and mRNA microarray analysis of the same sample in women with and without endometriosis

Reproductive Biology and Endocrinology, 2010
Background According to mRNA microarray, proteomics and other studies, biological abnormalities of eutopic endometrium (EM) are involved in the pathogenesis of endometriosis, but the relationship between mRNA and protein expression in EM is not clear. We
A. Fassbender, P. Simsa, C. Kyama, E. Waelkens, A. Mihályi, C. Meuleman, O. Gevaert, Raf Van de Plas, B. De Moor, T. D’Hooghe   +9 more
semanticscholar   +1 more source

Double blind control trial of vitamin D fortified milk on the expression of lncRNAs and adiponectin for patients with metabolic syndrome

Diabetology & Metabolic Syndrome, 2023
Background Metabolic syndrome (Mets) is a common metabolic disorder in which hypoadiponectinemia is one of the consequences for the body caused by inflammation, and vitamin D may help improve inflammatory symptoms.
Mohammad Rashidmayvan, R. Sahebi, A. Avan, P. Sharifan, H. Esmaily, A. Afshari, Elyas Nattagh-Eshtivani, Fatemeh Najar Sedghdoust, Maliheh Aghasizadeh, G. Ferns, M. Ghayour-Mobarhan   +10 more
semanticscholar   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

The Acute Responses of Different-sized Coronary Arteries to Testosterone [PDF]

, 2012
Coronary arteries supply blood to the myocardium. The blood flow within the coronary arteries is altered by various compounds produced within the body. Sex hormones such as testosterone are known to cause the relaxation of large coronary arteries.
Madanu, Sampath
core   +2 more sources

Standard methods for molecular research in Apis mellifera [PDF]

, 2013
From studies of behaviour, chemical communication, genomics and developmental biology, among many others, honey bees have long been a key organism for fundamental breakthroughs in biology.
Budge, G., Chen, Y.P., Cornman, R.S., De la Rúa, Pilar, Evans, J.D., Foret, S., Foster, L., Gauthier, L., Genersch, E., Gisder, S., Jarosch, A., Kucharski, R., Lopez, D., Lun, C.M., Maleszka, R., Miranda, J.R., Moritz, R.F.A., Muñoz, Irene, Pinto, M. Alice, Schwarz, R.   +19 more
core   +1 more source