Results 61 to 70 of about 114,931 (280)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

The Acute Responses of Different-sized Coronary Arteries to Testosterone [PDF]

, 2012
Coronary arteries supply blood to the myocardium. The blood flow within the coronary arteries is altered by various compounds produced within the body. Sex hormones such as testosterone are known to cause the relaxation of large coronary arteries.
Madanu, Sampath
core   +2 more sources

Standard methods for molecular research in Apis mellifera [PDF]

, 2013
From studies of behaviour, chemical communication, genomics and developmental biology, among many others, honey bees have long been a key organism for fundamental breakthroughs in biology.
Budge, G., Chen, Y.P., Cornman, R.S., De la Rúa, Pilar, Evans, J.D., Foret, S., Foster, L., Gauthier, L., Genersch, E., Gisder, S., Jarosch, A., Kucharski, R., Lopez, D., Lun, C.M., Maleszka, R., Miranda, J.R., Moritz, R.F.A., Muñoz, Irene, Pinto, M. Alice, Schwarz, R.   +19 more
core   +1 more source

Establishment and optimization of the two‐step induction system for generating primordial germ cell‐like cells from chicken embryonic stem cells

FEBS Open Bio, EarlyView.
This study optimizes a two‐step induction system to generate PGCLCs from chicken ESCs. The induced cells express germline markers and migrate to gonads in ovo, offering a novel approach for avian genetic resource conservation. Primordial germ cells (PGCs) are the progenitor cells of sperm and eggs.
Zeyu Li, XianShuai Xu, GuangZheng Liu, XiaoQian Lv, JiuZhou Song, HongYan Sun, YingJie Niu, QiSheng Zuo, Wei Han, BiChun Li, Kai Jin   +10 more
wiley   +1 more source

A Newly Discovered Bordetella Species Carries a Transcriptionally Active CRISPR-Cas with a Small Cas9 Endonuclease [PDF]

, 2015
Background Clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated genes (cas) are widely distributed among bacteria.
Dudley, Edward G., Harvill, Eric T., Hu, Kai, Ivanov, Yury V., Linz, Bodo, Register, Karen B., Rivera, Israel, Shariat, Nikki   +7 more
core   +2 more sources

Insight of PBZ mediated drought amelioration in crop plants

Frontiers in Plant Science, 2022
Water scarcity is a significant environmental limitation to plant productivity as drought-induced crop output losses are likely to outnumber losses from all other factors.
Chirag Maheshwari, N. Garg, Muzaffar Hasan, P. V, N. Meena, Ashutosh Kumar Singh, A. Tyagi   +6 more
semanticscholar   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

Nucleic acids in inclusion bodies obtained from E. coli cells expressing human interferon-gamma

Microbial Cell Factories, 2020
Background Inclusion bodies (IBs) are protein aggregates in recombinant bacterial cells containing mainly the target recombinant protein. Although it has been shown that IBs contain functional proteins along with protein aggregates, their direct ...
Elena Krachmarova, Ivan Ivanov, Genoveva Nacheva   +2 more
doaj   +1 more source

Incubation temperature affects type X collagen expression in embryonic ducks [PDF]

, 2014
Optimal temperature regulation is an important component of avian incubation and the process of embryonic development can be accelerated by even small increases in incubation temperature.
Prickett, Amanda L.
core  

TRIzol treatment of secretory phase endometrium allows combined proteomic and mRNA microarray analysis of the same sample in women with and without endometriosis

Reproductive Biology and Endocrinology, 2010
Background According to mRNA microarray, proteomics and other studies, biological abnormalities of eutopic endometrium (EM) are involved in the pathogenesis of endometriosis, but the relationship between mRNA and protein expression in EM is not clear. We
A. Fassbender, P. Simsa, C. Kyama, E. Waelkens, A. Mihályi, C. Meuleman, O. Gevaert, R. Van de Plas, B. De Moor, T. D’Hooghe   +9 more
semanticscholar   +1 more source